DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-4 and smyd1a

DIOPT Version :9

Sequence 1:	NP_572675.1	Gene:	SmydA-4 / 32034	FlyBaseID:	FBgn0030257	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_991103.2	Gene:	smyd1a / 321245	ZFINID:	ZDB-GENE-030131-9825	Length:	485	Species:	Danio rerio

Alignment Length:	465	Identity:	104/465 - (22%)
Similarity:	167/465 - (35%)	Gaps:	128/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TEEKELPYRVEHSDIYGRYLVANRQLEAGETLIREEPLAIGPCVSGD----PVCLGCYHPVSLKA 102
            |.||..|..|..:.:.||.|...|.|.|||.:..|...|   .|..|    .||..|:.   .:.
Zfish     2 TVEKTDPVEVFGAGLKGRGLRGTRDLSAGEVVFAEASFA---AVVLDSLSLQVCHSCFR---RQV 60

  Fly   103 DQYRCPGCAWP-LCGSTC---AGLKHRHGHTETECQLYAERRAVAGELLTERAGPAEVRDLYELV 163
            :.:||..|.:. .|..||   |..:||     .||...   |.:.      :|....||
Zfish    61 NPHRCAQCKFAHYCDRTCQRAAWDEHR-----KECSAI---RNIG------KAPNENVR------ 105

  Fly   164 MIVRIL-LLRQH----DPEQFALIARMESHTEERRQNAVLWRHYEEKV-VQRLRVTW--QLEDLE 220
            ::.||| .:::|    ...|...:..:|.|........:    .|.|| |:.....|  :.:.:.
Zfish   106 LVARILWRIQKHTGLVSDSQLTTLDMLEDHLSRMTPEDL----KELKVDVKTFYTYWPKKSKAVG 166

  Fly   221 AEQVHEVCGILDVNCFEIG-QNGAKA--RTLYPSAFLLAHDCTPNTA---HTDDPSSFEILLRTS 279
            .:.|..:.|::..|.|.:. |.|.::  ..|:|:..|:.|||.||..   :..|.|:.:....:|
Zfish   167 EDYVSHLFGVISCNGFTLSDQRGLQSVGIGLFPNLCLVNHDCWPNCTVILNHGDQSALDASFHSS 231

  Fly   280 RRVRER--------EALTLSYAYTLQGTLKRRAFMHEGKLFWCCCRRCSD-----------PREL 325
            ||:..|        :.||:||...|..:..|:..:.:...|.|.|..|.:           |.|.
Zfish   232 RRIELRALEPISAGQELTVSYVDFLSVSTDRQRLLQQQYYFDCKCEHCVNGTKDELMTAVKPTED 296

  Fly   326 GTDCSALVCATCRTGSVRA---VDPLQQTGDW-----ACDRCAHKMGATEVERQLDRINNDLEDI 382
            |...||.|.......|::|   ::..:..|::     .|..|..|....            ..|.
Zfish   297 GKQPSAEVVKQLTDFSLQALVKIEAARAQGNFHEVIRICRECLEKQDPV------------FADT 349

  Fly   383 DVHDIPGLE------NFLLRYRD--------------VLRPN----------------HYLLLSA 411
            :||.:..|.      :||.::::              :..||                |..|:.|
Zfish   350 NVHVLRVLSTASEVLSFLQQFQEAAGYAQRMVDGYMKLYHPNNAQLGMAIMRAGVTHWHAGLIEA 414

  Fly   412 KYSL-CQIYG 420
            .:.| |:.||
Zfish   415 AHGLICRAYG 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-4	NP_572675.1	None
smyd1a	NP_991103.2	zf-MYND	52..90	CDD:280009	11/45 (24%)
smyd1a	NP_991103.2	SET	<203..252	CDD:279228	14/48 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11197
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820