DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and ADAMTS3

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_055058.2	Gene:	ADAMTS3 / 9508	HGNCID:	219	Length:	1205	Species:	Homo sapiens

Alignment Length:	463	Identity:	96/463 - (20%)
Similarity:	145/463 - (31%)	Gaps:	157/463 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CREAQLCCNGRDSS--CVVQKAPINAIIEDLSDKPCYCDHACLKLGDCCDDFKDHCGVLDC---- 84
            |:  ||.|:..|:.  |..:|.|.....|..:.|.||               |.||...:.
Human   502 CK--QLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCY---------------KGHCMWKNANQQK 549

  Fly    85 QVGDWGAWSE---CDRSCGTGMMTRNRQILQAAQ-NGGKHCPTLQ-QKRSCQGYRCHGHHDKKIL 144
            |.|:||:|::   |.|:||||:..|.||...... |||:.||.:. :.:.|....|..|.:....
Human   550 QDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRA 614

  Fly   145 REMALLLPAALTHNHHVNESGDLRHNLRTRYRDTYKHNHDQEYCVEFE---------VIKSSKAC 200
            ::       ....|.|........|.|...:.|..|..|  .||...|         ::.....|
Human   615 QQ-------CQQRNSHFEYQNTKHHWLPYEHPDPKKRCH--LYCQSKETGDVAYMKQLVHDGTHC 670

  Fly   201 NKLPPYNLMTEGDRITVRCDLEA---LIQDSAG------------SSTTARTP------------ 238
            :...||::...|:.:.|.||.|.   .::|..|            ..|..|||
Human   671 SYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIP 735

  Fly   239 ---------QGPTTPSTTTVSSAASAF------GQ----RT-------------DDLE------- 264
                     :...:|....:.:.|:..      |:    ||             ||:|
Human   736 PGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGP 800

  Fly   265 -----------EERLQRETSSEEEATNQDGEAEEEDEEPEQDEQDDLQNALDSDSN--------- 309
                       :|...|.:.:.:...::|...........|:|.|..:.||.|.|.
Human   801 LHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGF 865

  Fly   310 ESTDYRHQRQSQMSQMSHSRRTAGKRSAVPATPSP----------TLP---------PTYHCRGE 355
            :.|.|..:|:|....:..|...|.|:      |.|          |.|         .|..|...
Human   866 QYTKYGCRRKSDNKMVHRSFCEANKK------PKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSS 924

  Fly   356 GLAGRTTR 363
            |...||.|
Human   925 GYQLRTVR 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	4/25 (16%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	19/54 (35%)
ADAMTS3	NP_055058.2	Pep_M12B_propep	66..200	CDD:279848
		ZnMc_ADAMTS_like	256..457	CDD:239801
		Reprolysin	258..460	CDD:279729
		TSP1	554..605	CDD:214559	18/50 (36%)
		Spacer	713..844		16/130 (12%)
		ADAM_spacer1	713..827	CDD:283607	14/113 (12%)
		TSP1	848..904	CDD:214559	13/61 (21%)
		TSP1	912..967	CDD:214559	6/21 (29%)
		TSP1	970..1015	CDD:214559
		PLAC	1023..1051	CDD:285849
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1174..1205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910