DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and THSD7B

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001303278.1	Gene:	THSD7B / 80731	HGNCID:	29348	Length:	1606	Species:	Homo sapiens

Alignment Length:	463	Identity:	95/463 - (20%)
Similarity:	147/463 - (31%)	Gaps:	168/463 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLPFVSGGSCREAQLC-CN-------GRDSSCVV---QKAPINAIIEDLSDKPCYCDHACLKLGD 70
            |.|.|      |.:|| |:       |..|.|::   ::.|...:......|.|         |:
Human   912 LYPLV------ETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKEC---------GE 961

  Fly    71 -------CCDD----------------FKDHCGV---LDCQVGDWGAWSECDRSCGTGMMTRNRQ 109
                   .|.|                .::.|.:   .||::.||.:|..|..|||.|:..|::.
Human   962 GLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKW 1026

  Fly   110 ILQAAQNGGKHCPTLQQKR----------SCQGYRCHGHH--DKKILREMALLLPAALTHNHHV- 161
            :.:...|||:.||.|..|.          .|..|.....|  ..||..|:..|.....|.:..:
Human  1027 LKEKPYNGGRPCPKLDLKNQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIR 1091

  Fly   162 ------NESGDLRHNLRTRYRDTYKHNHDQEYCVEFEVIKSSKACNKLPPYN-LMTEG------- 212
                  .|.|.:..||                |.:.|:...:::|:.:.|.. :|:|.
Human  1092 CVNTADGEGGAVDSNL----------------CNQDEIPPETQSCSLMCPNECVMSEWGLWSKCP 1140

  Fly   213 ---DRITVRCDLEALIQDSAGSSTTARTPQ---------------GPTTPSTTTVS-SAASAFGQ 258
               |..|::.....|::.|..|.|.|...|               ..|..||..:| :|....|.
Human  1141 QSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGV 1205

  Fly   259 RTDDLEEERLQRETSSEEEATNQDGEAEEEDEEPEQDEQDDLQNALDSDSNESTDYRHQRQS--- 320
            ||      ||.....|:.:..:.|           |.||.:|:             :.||.|
Human  1206 RT------RLLSCVCSDGKPVSMD-----------QCEQHNLE-------------KPQRMSIPC 1240

  Fly   321 --------QMS---QMSHSRRTAGKRSAVPATPSPTLPPTYHCRGEGLAGRT--TRWSALPAPSC 372
                    |:|   ..:...:|.|....:..|....:|    .:|||....|  |:....|...|
Human  1241 LVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMP----TQGEGRPCPTELTQEKTCPVTPC 1301

  Fly   373 ----RGKW 376
                .|.|
Human  1302 YSWVLGNW 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	5/48 (10%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	18/59 (31%)
THSD7B	NP_001303278.1	TSP1	182..233	CDD:214559
		TSP_1	340..388	CDD:387593
		TSP1	605..660	CDD:214559
		TSP1	1251..1301	CDD:214559	11/53 (21%)
		TSP1	1374..1430	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1583..1606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910