DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42339 and FRAS1

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_079350.5	Gene:	FRAS1 / 80144	HGNCID:	19185	Length:	4012	Species:	Homo sapiens

Alignment Length:	252	Identity:	54/252 - (21%)
Similarity:	75/252 - (29%)	Gaps:	87/252 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CREAQLCCNGRDSSCVVQKAPINAIIEDLSDKPC------YCDHACLKLGDCCDDFKDHCGVLDC 84
            ||.||:.|  .:.||  ...|:..:..::..:.|      :|...||    .|....|||.:  |
Human   384 CRGAQVTC--YEPSC--PPCPVGTLALEVKGQCCPDCTSVHCHPDCL----TCSQSPDHCDL--C 438

  Fly    85 Q------VGDWGAWSECDRSCGTGMMTRNRQILQAAQNGGKHCPTLQQKRSCQGYRCHGHHDKKI 143
            |      ...|     |..|||.|........| |.|.....|.:..:..|||.
Human   439 QDPTKLLQNGW-----CVHSCGLGFYQAGSLCL-ACQPQCSTCTSGLECSSCQP----------- 486

  Fly   144 LREMALLLPAALTHNHHVNESGDLRHNLRTRYRDTYKHNHDQEYCVEF------EVIKSSKACNK 202
                    |..:.|...|...||          ..|:..|....|.|.      ...|...||.
Human   487 --------PLLMRHGQCVPTCGD----------GFYQDRHSCAVCHESCAGCWGPTEKHCLACR- 532

  Fly   203 LPPYNLMTEGDRITVRCDLEALIQDSAG------SSTTARTPQ-----GPTTPSTTT 248
             .|.:::.:|.     |      :.|.|      ..|.:...|     ||::|...|
Human   533 -DPLHVLRDGG-----C------ESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLT 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	6/31 (19%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	13/49 (27%)
FRAS1	NP_079350.5	VWC	28..87	CDD:214564
		VWC	95..152	CDD:278520
		VWC	159..216	CDD:278520
		VWC	221..278	CDD:278520
		VWC	285..342	CDD:214564
		VWC	367..416	CDD:214564	9/35 (26%)
		FU 1	409..460		16/61 (26%)
		Furin-like	462..620	CDD:279142	30/159 (19%)
		FU 2	462..505		12/72 (17%)
		FU	462..504	CDD:214589	12/71 (17%)
		FU 3	507..553		11/58 (19%)
		FU	507..552	CDD:214589	11/57 (19%)
		FU 4	555..599		6/23 (26%)
		FU	556..598	CDD:214589	6/22 (27%)
		FU 5	602..647
		FU	608..653	CDD:238021
		FU 6	649..705
		FU	650..704	CDD:214589
		GF_recep_IV	655..777	CDD:291509
		FU 7	708..753
		FU	708..752	CDD:214589
		FU 8	755..800
		FU	755..799	CDD:214589
		FU 9	803..852
		FU	804..851	CDD:214589
		Furin-like	841..1056	CDD:279142
		FU 10	854..900
		FU	859..907	CDD:238021
		FU 11	903..948
		FU 12	952..997
		FU	952..996	CDD:214589
		FU 13	999..1042
		FU	999..1041	CDD:214589
		Furin-like_2	1009..1099	CDD:292535
		FU 14	1046..1089
		FU	1046..1087	CDD:214589
		Cadherin_3	<1101..1183	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1102..1197
		Cadherin_3	1168..1310	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1217..1308
		Cadherin_3	1279..1438	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1329..1438
		Cadherin_3	1409..1574	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1463..1559
		Cadherin_3	1529..1691	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1595..1689
		Cadherin_3	1660..1811	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1710..1810
		Cadherin_3	1778..1938	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1833..1936
		Cadherin_3	1904..2059	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1957..2057
		Cadherin_3	2028..2179	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2078..2177
		Cadherin_3	2147..2293	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2199..2291
		Cadherin_3	2261..2406	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2311..2404
		Cadherin_3	2375..2537	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2439..2536
		Calx_beta	2555..2650	CDD:197594
		Calx-beta	2675..2764	CDD:295344
		Calx-beta	2798..2894	CDD:295344
		Calx-beta	2920..3011	CDD:295344
Calx-beta	3039..3133	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910