DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42339 and PCSK6

DIOPT Version :9

Sequence 1:NP_572674.3 Gene:CG42339 / 32033 FlyBaseID:FBgn0259241 Length:395 Species:Drosophila melanogaster
Sequence 2:NP_002561.1 Gene:PCSK6 / 5046 HGNCID:8569 Length:969 Species:Homo sapiens


Alignment Length:234 Identity:48/234 - (20%)
Similarity:70/234 - (29%) Gaps:92/234 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SCREAQLCCNGR-------DSSCVVQKAPINAIIEDLSDKPCY-CDHACLKLGDCCDDFKDHCGV 81
            |.|.|..|.:.|       :.:..|...|. ....|.|.|.|. |..:|.|    |.|..:.|.|
Human   757 SSRAATQCLSCRRGFYHHQEMNTCVTLCPA-GFYADESQKNCLKCHPSCKK----CVDEPEKCTV 816

  Fly    82 L-------------DCQVGDWG-----AWSECDRSCGTGMMTRNRQILQAAQNGGKH-------C 121
            .             ||:.|.:.     ...||..:|||.:.....:.:..|:|...|       |
Human   817 CKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPAC 881

  Fly   122 ---------PTLQQK---------RSCQG-----YRCHGHHDKKILREMALLLPAALTHNHHVNE 163
                     |.|..|         .||.|     .||.....:         |..:...||..: 
Human   882 GEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQ---------LGTSCITNHTCS- 936

  Fly   164 SGDLRHNLRTRYRDTYKHNHDQEYCVEFEVIKSSKACNK 202
                              |.|:.:|   |::||::.|.:
Human   937 ------------------NADETFC---EMVKSNRLCER 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42339NP_572674.3 Somatomedin_B <53..79 CDD:279385 9/26 (35%)
TSP1 86..136 CDD:214559 17/84 (20%)
PCSK6NP_002561.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
S8_pro-domain 73..149 CDD:293079
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 160..454 CDD:173789
Peptidase_S8 196..479 CDD:278510
P_proprotein 539..629 CDD:279782
Cell attachment site. /evidence=ECO:0000255 553..555
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..683
FU 1 692..739
CRM (Cys-rich motif) 695..930 39/186 (21%)
FU 695..747 CDD:238021
FU 743..789 CDD:214589 7/32 (22%)
Furin-like_2 751..847 CDD:292535 21/94 (22%)
FU 799..845 CDD:238021 10/49 (20%)
FU 844..886 CDD:214589 9/41 (22%)
FU 5 895..943 11/75 (15%)
FU 896..930 CDD:214589 7/42 (17%)
PLAC 942..965 CDD:285849 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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