DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and Thsd7a

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001178899.2	Gene:	Thsd7a / 500032	RGDID:	1566201	Length:	1645	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	103/505 - (20%)
Similarity:	162/505 - (32%)	Gaps:	168/505 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PQRQLLPFVSGGSCREAQLCCNG------RDSSCVVQKAPINA---IIEDLSDKPCYCDHACLKL 68
            |..|..|.:| .|..:|:.|..|      |:.:|:.:...|.|   |.|....|| ..:.|||
  Rat   117 PWNQCQPVIS-KSLEKARECVKGEEGIQVREITCIQKDKDIPAEDIICEYFEPKP-LLEQACL-- 177

  Fly    69 GDCCDDFKDHCGVLDCQVGDWGAWSECDRSCGTGMMTRNRQILQAAQNGGKHCPTLQQKRSCQGY 133
             ..|..        ||.|.::.:||||.|:||:|:..|.|.::...|.||..||.|.:.:.||..
  Rat   178 -IPCQQ--------DCIVSEFSSWSECSRTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSN 233

  Fly   134 RCHGHHDKKILREMALLLPAALTHNHHVN----------------------ESGDLRHNLRTRYR 176
            .|........| ::......::.|:....                      |:.:|....|.|.|
  Rat   234 PCEAEESMYSL-QVGPWSACSVPHSRQARQARRRGKNKEREKERGKAVKDPEARELIKKKRNRNR 297

  Fly   177 DTYKHNH-----------------------DQEYCVEFEVIKSSKACNKLPPYNLMTEGDRITVR 218
            ...:.|.                       |..:|.:..:..:.::|             .||..
  Rat   298 QNRQENRYWDIQIGYQTRDVMCLNRTGKSADLSFCQQERLPMTFQSC-------------VITKE 349

  Fly   219 CDLEALIQDSAGSSTTARTPQGPTTPSTTTVSSAASAFGQRTDDLEEERLQRETSSEEEATNQ-D 282
            |.    :.:.:..|..::|....|:|:.|.|.:...    |...:..|:...|...:|...:| |
  Rat   350 CQ----VSEWSEWSPCSKTCHDVTSPTGTRVRTRTI----RQFPIGSEKECPELEEKEPCLSQGD 406

  Fly   283 G------------EAEEEDEEP---EQDEQDDLQNALDSDSNESTD-------------YRHQRQ 319
            |            |..|...:|   :||::...|.||.....::.:             ...|:.
  Rat   407 GAVLCATYGWRTTEWTECHVDPLLSQQDKRRANQTALCGGGVQTREIYCIQTNDILLSHINTQKD 471

  Fly   320 SQMSQMSHSRRTAGKRSAVPAT------PSPTL----------PPTY-HCR-------------- 353
            .:.|:...|:...|   .||.|      |.|..          |.|| :|.
  Rat   472 KEASKPVDSKLCTG---PVPNTTQLCHVPCPIECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRR 533

  Fly   354 -------GEGLAGRTTR-WSALPA--PSCRGKWLRLTVGP-----PKKCG 388
                   |.|..|.... ..|:|.  |||. .|..:.:|.     .|.||
  Rat   534 ITNEPTGGSGATGNCPHLLEAIPCEEPSCY-DWKSVRLGDCEPDNGKACG 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	6/25 (24%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	19/49 (39%)
Thsd7a	NP_001178899.2	TSP1_spondin	184..235	CDD:408798	20/50 (40%)
		TSP1_spondin	350..401	CDD:408798	11/58 (19%)
		TSP1_spondin	624..683	CDD:408798
		TSP1_ADAMTS	688..757	CDD:408800
		TSP1_spondin	1025..>1065	CDD:408798
		TSP1_ADAMTS	1088..1151	CDD:408800
		TSP1_spondin	1155..1206	CDD:408798
		TSP1_spondin	1276..1329	CDD:408798
		TSP1_spondin	1404..1463	CDD:408798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910