DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and Thsd7b

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_038946352.1	Gene:	Thsd7b / 289007	RGDID:	1306938	Length:	1609	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	107/499 - (21%)
Similarity:	155/499 - (31%)	Gaps:	175/499 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QRQLLPFVSG--GSC---REAQLCCNGRDSSCVVQKAPINAIIEDLSDKPCYCDHACLKLGD--- 70
            ||.:|...:|  |.|   .|:..|   .|..|....|         |:..|..||....||.
  Rat   514 QRHVLMESTGPVGHCPHLAESVPC---EDPMCYRWLA---------SEGICIPDHGKCGLGHRIL 566

  Fly    71 --CCDDFKDH------CGV--------------LDCQVGDWGAWSECDRSCGT----GMMTRNRQ 109
              .|.:.:..      |.|              :||.|.:|..||.|.:||..    |..||:|.
  Rat   567 KAVCQNERGEEVSGGLCPVPPPPERMACEIPCRMDCVVSEWTVWSSCSQSCSNKNSDGKQTRSRS 631

  Fly   110 ILQAAQNGGKHCPTLQQKRSCQGYR-CHGHHDKKILREMAL-------LLPAALTHNHHVNESGD 166
            |:..|..|||.||..|:   .|.|| |:.|...::..|.:.       .|..||..:...|....
  Rat   632 IVALAGEGGKPCPGSQE---LQEYRLCNDHSCAQLYWETSAWGSCSENTLVTALNMSIGWNGEAT 693

  Fly   167 LRHNLRTRYRDTYKHNHDQEYCVEFEVIKSSKACNKLPPYNLMTEGDRITVR-----CDLEALIQ 226
            ....::||          :.:|::..|   .:...|..|.:...|    |||     |..:.|:
  Rat   694 CGVGIQTR----------KVFCIKSHV---GQVMTKRCPESTRPE----TVRPCFLPCKKDCLV- 740

  Fly   227 DSAGSSTTA----RTPQGPTTPSTTT---------VSSAASAFGQRTDDLEEERLQRETS----- 273
                   ||    |....|..|..||         :..||:...:..|.|.|||...:.|
  Rat   741 -------TAFSEWRPCPWPCQPGNTTIKQSRYRIIIQEAANGGQECPDTLFEERECEDISLCPTY 798

  Fly   274 -------------SEEEATNQDGEAE---------------EEDEEPEQDEQDDLQNALD----- 305
                         .|.....:.|.:|               ::::..|..|.....|.:.
  Rat   799 RWKPQKWSPCILVPESIRQGRTGTSEACGKGLQTRDVSCISDDNQSAEMTECLRQMNGMPPLVQE 863

  Fly   306 --------------------SDSNESTDYRHQRQSQMSQMSHSRRTAGKRSAVPATPSPTLPPTY 350
                                |.:.|:|..|.::.:..|:.....:.|.....|...|.|......
  Rat   864 CTIACREDCTFTPWSKFTPCSKNCEATQIRRRQLTGKSRKKERCQDASLYPLVELEPCPCDAFMS 928

  Fly   351 HCRGEGLAGRTTRWSA--LPA----PSCRGKWLRLTVGPPKKCG 388
            |..|        .|||  ||.    |...|.|::   |..|:||
  Rat   929 HPYG--------NWSACILPEGKRDPQQGGLWVQ---GDDKECG 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	7/36 (19%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	22/54 (41%)
Thsd7b	XP_038946352.1	TSP1_ADAMTS	44..95	CDD:408800
		TSP1_spondin	180..229	CDD:408798
		TSP1_spondin	337..398	CDD:408798
		TSP1_spondin	602..660	CDD:408798	25/60 (42%)
		TSP1_ADAMTS	665..734	CDD:408800	15/85 (18%)
		TSP1_spondin	738..789	CDD:408798	15/58 (26%)
		TSP1_ADAMTS	1065..1125	CDD:408800
		TSP1_spondin	1131..1177	CDD:408798
		TSP1_spondin	1251..1304	CDD:408798
		TSP1_spondin	1374..1433	CDD:408798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910