DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and SBSPON

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_694957.3	Gene:	SBSPON / 157869	HGNCID:	30362	Length:	264	Species:	Homo sapiens

Alignment Length:	397	Identity:	89/397 - (22%)
Similarity:	121/397 - (30%)	Gaps:	162/397 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QLLPFVSGGSCREAQLCCNGRDSSCVVQKAPINAIIEDLSDKPCYCDHACLKLGDCCDDFKDHCG 80
            :|.|....| |.||..||.|||.:|..:...::.:.     ..|:||.||...||||.|:...|.
Human    13 RLWPGAQAG-CAEAGRCCPGRDPACFARGWRLDRVY-----GTCFCDQACRFTGDCCFDYDRACP 71

  Fly    81 VLDCQVGDWGAWSECDRSCGTGMMTRNRQILQAAQNGGKHCPTLQQKRSC------QGYRCHGHH 139
            ...|.||:|..||.|...|......|.|.:.|..||||..||.|:::..|      ||..| ||
Human    72 ARPCFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGCLEYSTPQGQDC-GH- 134

  Fly   140 DKKILREMALLLPAALTHNHHVNESGDLRHNLRTRYRDT---YKHNHDQEYCVEFEVIKSSKACN 201
                     ..:||.:|.:....|        |||...:   ..|..|..||:||:....:..|
Human   135 ---------TYVPAFITTSAFNKE--------RTRQATSPHWSTHTEDAGYCMEFKTESLTPHC- 181

  Fly   202 KLPPYNL------MTEGDRITVRCDLEALIQDSAGSSTTARTPQGPTTPSTTTVSSAASAFGQRT 260
            .|..:.|      :.||..:.|.|.                      .|:..:||...|..|
Human   182 ALENWPLTRWMQYLREGYTVCVDCQ----------------------PPAMNSVSLRCSGDG--- 221

  Fly   261 DDLEEERLQRETSSEEEATNQDGEAEEEDEEPEQDEQDDLQNALDSDSNESTDYRHQRQSQMSQM 325
                                                       ||||.|:
Human   222 -------------------------------------------LDSDGNQ--------------- 228

  Fly   326 SHSRRTAGKRSAVPATPSPTLPPTYHCRGEGLAGRTTRWSALPAPSCRGKWLRLTVGPPKKCG-- 388
                                               |..|.|:..|.|:|.|.::.......|.
Human   229 -----------------------------------TLHWQAIGNPRCQGTWKKVRRVDQCSCPAV 258

  Fly   389 HAQFIFV 395
            |: |||:
Human   259 HS-FIFI 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	10/25 (40%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	20/55 (36%)
SBSPON	NP_694957.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144338
Domainoid	1	1.000	48	1.000	Domainoid score	I11971
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390796at33208
OrthoFinder	1	1.000	-	-		FOG0003374
OrthoInspector	1	1.000	-	-		oto90778
orthoMCL	1	0.900	-	-		OOG6_106929
Panther	1	1.100	-	-	O	PTHR20920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3505
SonicParanoid	1	1.000	-	-		X2727
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890