DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42339 and thsd7a

DIOPT Version :9

Sequence 1:	NP_572674.3	Gene:	CG42339 / 32033	FlyBaseID:	FBgn0259241	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_012821049.1	Gene:	thsd7a / 100495599	XenbaseID:	XB-GENE-6045599	Length:	1655	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	97/406 - (23%)
Similarity:	146/406 - (35%)	Gaps:	121/406 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QLLPFVSGGSCREAQLCCNG------RDSSCVVQKA----PINAIIEDLSDKPCYCDHACLKLGD 70
            |..|.:|..|.:..: |..|      |:.:| :|||    ..::|.|....|| ..:..||   .
Frog   112 QCKPVISRSSEKPTE-CTKGEEGIQTREVTC-IQKANGAVADDSICEYFEPKP-RLEQGCL---I 170

  Fly    71 CCDDFKDHCGVLDCQVGDWGAWSECDRSCGTGMMTRNRQILQAAQNGGKHCPTLQQKRSCQGYRC 135
            .|..        ||.|.::.:||||.|:||.|:..|.|.::..||.||..||.|.:.::||...|
Frog   171 PCPQ--------DCIVSEYSSWSECSRTCGNGLKHRTRYVITLAQFGGSACPNLTEYQTCQSAPC 227

  Fly   136 HGHHDKKILREMALLLPAALTHNHHVNESGDLRHNLRTRYRDTYKHNHDQEYCVEFEVIKSSKAC 200
            .|..:...| .:......::..:.||.::|....| |.|.::..|...|.|   ..|:||..:..
Frog   228 EGEENMYSL-SVGPWSSCSIPLSRHVRQTGKRGKN-RERAKEREKAVKDPE---ARELIKKKRNR 287

  Fly   201 N---------------------------------------KLPPYNLMTEGDRITVR-C--DLEA 223
            |                                       |||          ||.: |  |.|.
Frog   288 NRKNRQENRYWDIQIGYQTRLVTCMHRNGKTAALSFCQQEKLP----------ITFQSCVIDKEC 342

  Fly   224 LIQDSAGSSTTAR-----TPQGPTTPSTTTVSSAASAFGQRTDDLEEERLQRETSSEEEATNQDG 283
            .:.:.|..|..:|     :|.|..| ...|:.......|....:|||        :|:.....||
Frog   343 QVSEWAEWSPCSRACDMESPGGYRT-RKRTIKLFPIGNGNECPELEE--------TEDCTPPPDG 398

  Fly   284 ---------EAEEEDE---EP---EQDEQDDLQNALDSDSNESTD-YRHQRQSQM---------S 323
                     .|.|..|   :|   :||::...|.||.....::.: |..|....:         .
Frog   399 PQVCIKYTWRATEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREIYCVQANENLLSYLNNVKDK 463

  Fly   324 QMSHSRRTAGKRSAVP 339
            :.|||..|: |.||.|
Frog   464 EESHSYSTS-KSSAAP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42339	NP_572674.3	Somatomedin_B	<53..79	CDD:279385	5/25 (20%)
CG42339	NP_572674.3	TSP1	86..136	CDD:214559	20/49 (41%)
thsd7a	XP_012821049.1	TSP1	178..228	CDD:214559	20/49 (41%)
		TSP1	344..396	CDD:214559	12/60 (20%)
		TSP1	640..693	CDD:214559
		TSP1	1037..>1075	CDD:214559
		TSP1	1287..1337	CDD:214559
		TSP1	1415..1471	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000