DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and Dll1

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_114452.2	Gene:	Dll1 / 84010	RGDID:	70949	Length:	714	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	122/371 - (32%)
Similarity:	162/371 - (43%)	Gaps:	99/371 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CEKSQKQRQNA--HYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGE 110
            |....:.|.:|  |:.|.|:|:..|.|||:|..|..|:|..|||..:|||.:||||:||:|:.|.
  Rat   187 CSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGR 251

  Fly   111 LCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTE--------PSCRTGCHSTRGYCEAPGE--- 164
            .||:||..|||.||.|.:|::|.|:.||.||||.:        ..||.|     ..|...|:
  Rat   252 YCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNG-----ATCTNTGQGSY 311

  Fly   165 -CRCRIGYAGRTC----SECATMPGCQHGTCNKPLE----CLCLPGYTGLLCQTPI--------- 211
             |.||.||.|..|    .|||..| |::|.....||    |.|.||:.|.:|:...
  Rat   312 TCSCRPGYTGANCELEVDECAPSP-CRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCF 375

  Fly   212 ----C--DPD---------------CSKQHGYCRKP-----------GE---CRCKVGWTGSQC- 240
                |  :||               |.|:...|...           |.   |||:.|::|..|
  Rat   376 NGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCE 440

  Fly   241 ---DKCFPYPGCANG----DCEAPWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSRED 298
               |.|...| ||||    |....:.|.|.||:.|..|...::.|...|  |.||..|....:.
  Rat   441 DNVDDCASSP-CANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAP--CHNGATCHQRGQR- 501

  Fly   299 GSYQCQCRQGFLGKNCEIRDDFLLTSEAPPRITPPTPAELVLELDG 344
              |.|:|.||:.|.||:    |||         |..|.:|::...|
  Rat   502 --YMCECAQGYGGANCQ----FLL---------PEPPPDLIVAAQG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	10/24 (42%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	12/34 (35%)
Dll1	NP_114452.2	MNNL	22..91	CDD:400141
		DSL	158..220	CDD:128366	12/32 (38%)
		EGF_CA	287..325	CDD:238011	11/42 (26%)
		EGF_CA	328..363	CDD:238011	13/35 (37%)
		EGF_CA	<372..402	CDD:238011	3/29 (10%)
		EGF_CA	405..440	CDD:238011	7/34 (21%)
		EGF_CA	442..477	CDD:238011	13/35 (37%)
		EGF	484..514	CDD:394967	12/34 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..690
		Interaction with MAGI1. /evidence=ECO:0000250\|UniProtKB:Q61483	711..714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910