DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and Megf6

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_075244.1	Gene:	Megf6 / 65049	RGDID:	621188	Length:	1574	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	108/433 - (24%)
Similarity:	141/433 - (32%)	Gaps:	180/433 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CEKSQKQRQNAHYVCDEK-GDFKCLPGWQGDLCQV--------PMCRR--------GCDPMNGYC 95
            ||:|..:.      |:.| |...|..|:||:.||.        |.||.        .|||::|.|
  Rat   660 CEQSHTRS------CNPKDGSCSCKAGFQGERCQAECESGFFGPGCRHRCTCQPGVACDPVSGEC 718

  Fly    96 --QRP------------------------------------GECRCRIGYSGELCDKCIP----- 117
              |.|                                    |||.|..|.:||.|....|
  Rat   719 RTQCPPGYQGEDCGQECPVGTFGVNCSGSCSCVGAPCHRVTGECLCPPGKTGEDCGADCPEGRWG 783

  Fly   118 ------LPGCQHGGCTKP--FECICKPGWAGLFCTEPSCR-----TGCH-----STRGYCE-APG 163
                  .|.|:||....|  ..|:|.||:.|..| :.:|.     |||.     :..|:|: ..|
  Rat   784 LGCQEICPACEHGASCNPETGTCLCLPGFVGSRC-QDTCSAGWYGTGCQIRCACANDGHCDPTTG 847

  Fly   164 ECRCRIGYAGRTCS----------ECATMPGCQ--HGTCNKPLE-CLCLPGYTGLLCQT------ 209
            .|.|..|:.|.:|.          :|.....|.  ||.|:.... |||..||.|..|:.
  Rat   848 RCSCAPGWTGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYEGPRCEQSCRQGY 912

  Fly   210 --PICDPDCSKQHGYC--RKPGECRCKVGWTGSQCDKCFPY------------------------ 246
              |.|:..|..:||..  ...|.|.|..||.||.|:...|.
  Rat   913 YGPSCEQKCRCEHGAACDHVSGACTCPAGWRGSFCEHACPAGFFGLDCDSACNCSAGAPCDAVTG 977

  Fly   247 ----------PGCA-------------------NG-DCEA-PWECNCHPGWGGMLCDEKLTYC-- 278
                      |.||                   || .|:: ..:|:|.|||.|..|   |..|
  Rat   978 SCICPAGRWGPRCAQSCPPLTFGLNCSQICTCFNGASCDSVTGQCHCAPGWMGPTC---LQACPP 1039

  Fly   279 ------VEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCE 315
                  .:|...|.|||:|..:..     ||.|.:|:.|..||
  Rat  1040 GLYGKNCQHSCLCRNGGRCDPILG-----QCTCPEGWTGLACE 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	7/23 (30%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	11/34 (32%)
Megf6	NP_075244.1	EMI	42..112	CDD:284877
		FXa_inhibition	127..162	CDD:291342
		vWFA	<154..202	CDD:294047
		vWFA	<237..285	CDD:294047
		vWFA	<284..325	CDD:294047
		FXa_inhibition	338..373	CDD:291342
		vWFA	<371..410	CDD:294047
		vWFA	<413..452	CDD:294047
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000