DRSC/TRiP Functional Genomics Resources

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Protein Alignment C901 and DLL4

DIOPT Version :10

Sequence 1:NP_572673.1 Gene:C901 / 32032 FlyBaseID:FBgn0021742 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_061947.1 Gene:DLL4 / 54567 HGNCID:2910 Length:685 Species:Homo sapiens


Alignment Length:318 Identity:124/318 - (38%)
Similarity:160/318 - (50%) Gaps:51/318 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 CEKSQKQRQN--AHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGE 110
            |.:..|:|.:  .||||...|:..|||||.|:.||.|:|..||...||||.:|.||.||.|:.|.
Human   184 CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGR 248

  Fly   111 LCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTE--------PSCRTGCHSTRGYCEAPGE--- 164
            ||::|||..||:||.|:.|::|.|..||.||||.:        ..|:.|     ..|...|:   
Human   249 LCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNG-----ATCSNSGQRSY 308

  Fly   165 -CRCRIGYAGRTC----SECATMPGCQHGTCNKPLE----CLCLPGYTGLLCQ--TPIC-DPDCS 217
             |.||.||.|..|    |||.:.| |::|...|..|    |||.|||.||.|:  |..| |..|.
Human   309 TCTCRPGYTGVDCELELSECDSNP-CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCF 372

  Fly   218 KQHGYCRKPGE-----CRCKVGWTGSQC----DKCFPYPGCAN-GDC--EAPWE-CNCHPGWGGM 269
             ..|.||:..:     |.|...:|||.|    |:|...| ||| |.|  ..|.. |.|.||:.|.
Human   373 -NGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-CANGGQCLNRGPSRMCRCRPGFTGT 435

  Fly   270 LCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRDDFLLTSEAP 327
            .|:..::.|..:|  |.:||.|..|  |:| ..|.|..||.|:.||:|......:.:|
Human   436 YCELHVSDCARNP--CAHGGTCHDL--ENG-LMCTCPAGFSGRRCEVRTSIDACASSP 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C901NP_572673.1 DSL <56..82 CDD:473190 13/27 (48%)
EGF_CA 280..315 CDD:238011 13/34 (38%)
DLL4NP_061947.1 MNNL 27..173 CDD:462222
DSL 175..220 CDD:460202 16/35 (46%)
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 185..187 0/1 (0%)
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 191..195 1/3 (33%)
EGF_CA 284..322 CDD:238011 10/42 (24%)
EGF_CA 327..360 CDD:238011 15/33 (45%)
EGF_CA 403..438 CDD:238011 14/35 (40%)
EGF_CA <447..476 CDD:238011 13/33 (39%)
Blue background indicates that the domain is not in the aligned region.

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