DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C901 and Dl

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	174/700 - (24%)
Similarity:	254/700 - (36%)	Gaps:	233/700 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLVTAITALKLEEMNAYRRN----------FDARQSSNSNIPLWKQRACEKSQKQRQNA--HYV 61
            ||:...:....||..:.::.|          :|.|.:.:.|   :....|.|..:.|.::  |..
  Fly   147 LLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLN---YYGSGCAKFCRPRDDSFGHST 208

  Fly    62 CDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGELCDKCIPLPGCQHGGC 126
            |.|.|:..||.|||||.|.:|.|.:||:  :|:|.:|.:|.|::|:.|.||::|:..|.|.||.|
  Fly   209 CSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTC 271

  Fly   127 TKPFECICKPGWAGLFCTEP--------SCRTGCHSTRGYCEAPGE----CRCRIGYAGRTCS-- 177
            .||:.|||..||.||:|.:.        .|:.|     |.|...||    |:|..||:|..|.
  Fly   272 NKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNG-----GTCFNTGEGLYTCKCAPGYSGDDCENE 331

  Fly   178 --EC-ATMPGCQH-GTC-NKP-----LECLCLPGYTGLLCQTPI--C-DPDCSKQHGYCR--KPG 227
              .| |.:..||: ||| ::|     .:|.|..|::|.:|:..:  | |..|  ..|.||  :||
  Fly   332 IYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC--HQGICRNVRPG 394

  Fly   228 --------ECRCKVGWTGSQC----DKCFPYPGCANGD------------------CEA------ 256
                    :|.|.:|::|..|    |.|.|.| |.||.                  ||.
  Fly   395 LGSKGQGYQCECPIGYSGPNCDLQLDNCSPNP-CINGGSCQPSGKCICPAGFSGTRCETNIDDCL 458

  Fly   257 ---------------PWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCR 306
                           .:.|.|.||:.|..|..|:..|:..|  |.|||.|.:|:.:   |||.||
  Fly   459 GHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRP--CANGGTCLNLNND---YQCTCR 518

  Fly   307 QGFLGKNCEIRDD-----------------------------------------------FLLTS 324
            .||.||:|.:..|                                               :..|:
  Fly   519 AGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATT 583

  Fly   325 EAPPRITPPTPAELVL-------------------------------ELDGELDQNGQQDI---- 354
            :|  |....|.|::||                               :.|.|..:..:|:.
  Fly   584 QA--RADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATM 646

  Fly   355 -----GAGVPDDSEPGGGLVGEK----LPAGNEP------ERRKNDTVANVATAGTGAGA----- 399
                 |.||...|...||..|..    ...||..      ::..|:..|:.|.|...|.|
  Fly   647 HHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECL 711

  Fly   400 ---GPMNSLPGNSNATRTTLVVATETGSDNATNEALSAVTTRRATPIPLTSGEKTVKGNATSVSV 461
               |.:.|:..|:||.....|...:...   :.:.|:...|......|..|..|...|.
  Fly   712 MYGGYVASVADNNNANSDFCVAPLQRAK---SQKQLNTDPTLMHRGSPAGSSAKGASGG------ 767

  Fly   462 ATGPQPRPPLPIVASQE-----QTIANLAPAGTVTVTATTAPTATTAATS 506
              ||.......|....|     |...:||.||.....::....|.:.|.|
  Fly   768 --GPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGACSSQLMAAASVAGS 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	11/24 (46%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	16/34 (47%)
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	18/64 (28%)
		EGF_CA	291..329	CDD:238011	11/42 (26%)
		EGF_CA	337..372	CDD:238011	11/34 (32%)
		EGF_CA	453..488	CDD:238011	5/34 (15%)
		EGF_CA	492..526	CDD:238011	17/38 (45%)
		EGF_CA	529..564	CDD:238011	1/34 (3%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44598at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020