DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and Dll4

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_006234827.1	Gene:	Dll4 / 311332	RGDID:	1309740	Length:	686	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	124/318 - (38%)
Similarity:	160/318 - (50%)	Gaps:	55/318 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ACEKSQKQRQN--AHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSG 109
            :|.:..|:|.:  .||.|...|...|||||.|..|..|:|..||...||||.:|.||.||.|:.|
  Rat   184 SCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQG 248

  Fly   110 ELCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTE--------PSCRTG--CHST--RGYCEAP 162
            .||::|||..||:||.||.|::|.|..||.||||.:        ..|:.|  |.::  |||
  Rat   249 PLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGY---- 309

  Fly   163 GECRCRIGYAGRTC----SECATMPGCQHGTCNKPLE----CLCLPGYTGLLCQ--TPIC-DPDC 216
             .|.|..||.|..|    |:||:.| |::|...|..|    |||.|||.|..|:  |..| |..|
  Rat   310 -TCTCLPGYTGEHCELELSKCASNP-CRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPC 372

  Fly   217 SKQHGYCRKPGE-----CRCKVGWTGSQC----DKCFPYPGCAN-GDC--EAPWE-CNCHPGWGG 268
            . ..|.||:..:     |.|...:|||.|    |:|...| ||| |.|  ..|.. |.|.||:.|
  Rat   373 F-NGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNP-CANGGQCLNRGPSRTCRCRPGFTG 435

  Fly   269 MLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRDDFLLTSEA 326
            ..|:..::.|...|  |.:||.|..|  |:|.. |.|..||.|:.||:|    :|::|
  Rat   436 THCELHISDCARSP--CAHGGTCHDL--ENGPV-CTCPAGFSGRRCEVR----ITNDA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	10/24 (42%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	13/34 (38%)
Dll4	XP_006234827.1	MNNL	28..89	CDD:284966
		DSL	156..218	CDD:279722	13/33 (39%)
		EGF_CA	285..323	CDD:238011	11/42 (26%)
		EGF_CA	329..361	CDD:238011	14/32 (44%)
		EGF_CA	<370..401	CDD:238011	9/31 (29%)
		EGF_CA	404..439	CDD:238011	14/35 (40%)
		EGF_CA	442..477	CDD:238011	14/39 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910