DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and dla

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_571029.2	Gene:	dla / 30131	ZFINID:	ZDB-GENE-980526-29	Length:	772	Species:	Danio rerio

Alignment Length:	493	Identity:	135/493 - (27%)
Similarity:	193/493 - (39%)	Gaps:	153/493 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CEKSQKQRQNA--HYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGE 110
            |....:.|.:|  |:.|.|:|:..|..||:|..|..|:|..|||..:|:|::||||:||:|:.|.
Zfish   190 CSVFCRPRDDAFGHFTCGERGEIICDAGWKGQYCTEPICLPGCDEEHGFCEKPGECKCRVGFKGR 254

  Fly   111 LCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTE--------PSCRTGCHSTRGYCEAPGE--- 164
            .||:||..|||.||.|.:|::|.|:.||.||||.:        ..|..|     ..|...|:
Zfish   255 YCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCLNG-----ATCSNTGQGSY 314

  Fly   165 -CRCRIGYAGRTC----SECATMPGCQHGTC---NKPLECLCLPGYTGLLCQTPI---------- 211
             |.||.|::|.:|    :||...|....|:|   .....|.|.||:.|..|:...
Zfish   315 TCSCRPGFSGASCEIEVNECTGNPCRNGGSCTDMENTYSCTCPPGFYGKNCELSAMTCADGPCFN 379

  Fly   212 ---C--DPD----CSKQHGY----CRKPGE---------------------CRCKVGWTGSQCDK 242
               |  :||    |....||    |.|..:                     |:|..|:||..||:
Zfish   380 GGRCADNPDGGYFCQCPTGYAGFNCEKKIDHCSSSPCSNGARCVDLVNSYLCQCPDGFTGMNCDR 444

  Fly   243 ----CFPYPGCAN-GDCE---APWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDG 299
                |..|| |.| |.|:   :.:.|.|.||:.|..|...::.|..:|  |.||..|   ...:.
Zfish   445 AGDECSMYP-CQNGGTCQEGASGYMCTCPPGYTGRNCSSPVSRCQHNP--CHNGATC---HERNN 503

  Fly   300 SYQCQCRQGFLGKNCEIRDDFLLTSEAPPRITPPTPAELVLELDGELDQNGQQDIGAGVPDDSEP 364
            .|.|.|..|:.|:||:    |||...|                         ..||:.||..:..
Zfish   504 RYVCACVSGYGGRNCQ----FLLPDRA-------------------------SQIGSDVPWTAVG 539

  Fly   365 GGGL---------------VGEKLPAGNEPERRKNDTVANVATAGTGAGAGPMNSLPGNSNATRT 414
            .|.|               |..|:   .:..|.:.|.|||....       .:|:|..|.:..:.
Zfish   540 SGVLLVLLLVVACAVVVVCVRSKV---QQRRRDREDEVANGENE-------TINNLTNNCHRDKD 594

  Fly   415 TLVVAT------------ETGSDNATNEALSAVTTRRA 440
            ..|...            :..||   ::.||..|.:|:
Zfish   595 LAVSVVGVAPVKNINKKIDFSSD---HDDLSMTTEKRS 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	9/24 (38%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	11/34 (32%)
dla	NP_571029.2	MNNL	23..94	CDD:284966
		DSL	161..223	CDD:128366	11/32 (34%)
		EGF_CA	290..328	CDD:238011	9/42 (21%)
		EGF_CA	331..366	CDD:238011	10/34 (29%)
		EGF_CA	<375..405	CDD:238011	6/29 (21%)
		EGF_CA	408..442	CDD:238011	5/33 (15%)
		EGF_CA	447..480	CDD:238011	12/33 (36%)
		EGF_CA	488..519	CDD:238011	11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910