DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and eat-20

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001024741.1	Gene:	eat-20 / 181641	WormBaseID:	WBGene00001148	Length:	810	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	174/475 - (36%)	Gaps:	158/475 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PSCRTGCHSTRGYC----EAPGECRCRIGYAGRTC--SECATMPGCQH-GTC---NKPLECLCLP 200
            |.....||: .|.|    |....|.||.|:.|..|  ..|:::| ||: |.|   |....|.|.|
Worm   223 PCANHECHN-NGTCLVSQEGAATCLCRNGFTGDRCELDVCSSVP-CQNGGVCRSNNGIAYCECPP 285

  Fly   201 GYTGLLCQT--------PICDPDCSKQHGYC-RKPG--ECRCKVGWTGSQC---DKCFPYPGCAN 251
            .:|||||::        |||.|:||  :|.| .|.|  :|.|:.|:||:.|   |.|.....|:.
Worm   286 AFTGLLCESAHTDESVAPICRPECS--NGQCVFKDGQAQCECRQGFTGANCNVLDVCLGDAACSM 348

  Fly   252 GDCEAPWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGK--NC 314
                          :|      .|..||    ..:|..|.:||:..:|:|.|.|.....|:  :|
Worm   349 --------------FG------PLAKCV----LDDNMDKMSSLTLINGTYDCLCPHPIHGQFVDC 389

  Fly   315 EIRDDFLLTSEAPPR---ITPPTPAELVLELDGELDQNGQQDIGAGVPDDSEPGGGLVGEKLPAG 376
            ........||..|..   |...||:..|||:                            .|||
Worm   390 MQLHAPSATSVQPTEQVVINNVTPSFPVLEI----------------------------SKLP-- 424

  Fly   377 NEPERRKNDTVANVATAGTGAGAGPMNSLPGNSNATRTTLVVATETGSDNATNEALS----AVTT 437
                              |||        |....||.|||:|...|.:.:.|::..|    ..|.
Worm   425 ------------------TGA--------PVTFTATSTTLMVTQPTVTVSPTHQVPSEPFVGFTV 463

  Fly   438 RRATPIPLTSGEKTVKGNATSVSVATGPQPRPPLPIVASQEQTIANLAPAGTVTVTATTAPTATT 502
            .||...||..|..|:........:..|.      |..:||:....:..|..|..:...|..|.|.
Worm   464 TRAPLRPLDIGSTTLPPPFNQHIITAGE------PTWSSQQPHQPSEVPTQTTFIFPQTPETTTF 522

  Fly   503 AATSVTS---HK-DKPNVADE-EEDEDDDDDEEDED-------------GEYD------------ 537
            |.|:.|.   || ..|:|.|| ||:|:::..||.|:             |::.
Worm   523 APTTGTQQPVHKFVSPSVPDENEEEEEEETTEETEETFPTPSTMQVATNGQFTTETAFVTSTIPS 587

  Fly   538 -----EEEDEDEDDEEDDSD 552
                 ||.|||||..|:.:|
Worm   588 TTTDMEETDEDEDMTEEVTD 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	9/36 (25%)
eat-20	NP_001024741.1	EGF_CA	224..257	CDD:238011	10/33 (30%)
eat-20	NP_001024741.1	EGF_CA	261..293	CDD:238011	14/32 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910