DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C901 and dlc

DIOPT Version :9

Sequence 1:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001096242.1	Gene:	dlc / 100124798	XenbaseID:	XB-GENE-968497	Length:	642	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	130/427 - (30%)
Similarity:	188/427 - (44%)	Gaps:	122/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVTAITALKLEEMN----------AYRRNFDARQSSNSNIPLWKQR-----------------A 47
            |::.:.|.:..|:..          |.||.....:..:.:|.|.:|.                 :
Frog   103 LIIESWTTVSAEQSTENPDNLLSRLATRRRLSVGEDWSQDIHLGQQSELRYSYHVSCDEHYYGDS 167

  Fly    48 CEKSQKQRQN--AHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGE 110
            |....:.|.:  .||.|||:|:..||.||:|:.|..|:|..||...:|:|:.||||:||:|:.|:
Frog   168 CSDYCRPRDDNFGHYTCDEQGNRLCLSGWKGEYCAEPICLPGCSESHGFCEIPGECKCRMGWQGQ 232

  Fly   111 LCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTEP--------SCRTG--CHSTRGYCEAPGEC 165
            |||:|:..||||||.|::|:||||:.||.||||.:.        .||.|  |.:|.   :....|
Frog   233 LCDECVRYPGCQHGSCSQPWECICQEGWGGLFCNQDLNYCTNHRPCRNGASCINTG---QGSYSC 294

  Fly   166 RCRIGYAGRTC----SECATMPGCQHGTCN---KPLECLCLPGY--------------------- 202
            .||.|:.|..|    :|||:.|....|:||   ...||:|..|:
Frog   295 NCRAGFTGTNCEIDINECASNPCKNGGSCNDLENDYECVCPRGFYGKNCDISAMTCEDGPCFNGG 359

  Fly   203 --------TGLLCQTPI--CDPDCSKQ-----------HGYCRKPGE---CRCKVGWTGSQC--- 240
                    .|.:|:.|:  ...:|.|:           .|.|...|.   |:|:.|::|.:|
Frog   360 TCIEKSSGVGYICRCPLNYHGSNCEKKIDRCTNSPCLNGGQCLDMGRNVLCKCRPGFSGPRCELN 424

  Fly   241 -DKCFPYPGCANG----DCEAPWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKC-TSLSREDG 299
             |.|...| ||||    |....:.|:|..|:||..|..::..|...|  |.|||.| |..|
Frog   425 IDDCASNP-CANGGTCVDAVNSYTCSCTLGYGGKDCTLRVDACSSQP--CSNGGTCFTHFS---- 482

  Fly   300 SYQCQCRQGFLGKNCEIRDDFLLTSEAPPRITPPTPA 336
            .:.|||..||:|.:||.            |:..||||
Frog   483 GHVCQCPTGFMGTSCEF------------RVHDPTPA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..79	CDD:302925	11/24 (46%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	14/35 (40%)
dlc	NP_001096242.1	MNNL	22..76	CDD:284966
		DSL	139..201	CDD:279722	16/61 (26%)
		EGF_CA	268..306	CDD:238011	10/40 (25%)
		EGF_CA	308..343	CDD:238011	11/34 (32%)
		EGF_CA	387..422	CDD:238011	7/34 (21%)
		EGF_CA	424..460	CDD:238011	13/36 (36%)
		EGF_CA	463..498	CDD:238011	15/40 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910