Protein Alignment Rab9Fb and RAB35

DIOPT Version :10

• Sequence 1: NP_727472.1
• Gene: Rab9Fb / 32029
• FlyBaseID: FBgn0052670
• Length: 214
• Species: Drosophila melanogaster
• Sequence 2: NP_006852.1
• Gene: RAB35 / 11021
• HGNCID: 9774
• Length: 201
• Species: Homo sapiens
• Alignment Length: 211
• Identity: 85/211 - (40%)
• Similarity: 132/211 - (62%)
• Gaps: 14/211 - (6%)

  Fly     4 YDYLFKILVLGDIGVGKSCLLMRFSDNRFTEKHVCTVGMDFRVRNVELAGRMVMLQIWDTAGDER 68
            ||:|||:|::||.|||||.||:||:||.|:..::.|:|:||::|.||:.|..|.||||||||.||
Human     5 YDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQER 69

  Fly    69 FKSLLPSYYRGAHGILLVYDITSSKSFRNIDGWLKEIRRMSSESVNVMLVGNKCDDLDNRQVRME 133
            |:::..:||||.||:::|||:||::||.|:..||.||.: :.:.|..:|||||.||.:.:.|..|
Human    70 FRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQ-NCDDVCRILVGNKNDDPERKVVETE 133

  Fly   134 QGFNYANHRALGFYEVSAKSGANVNDVFNMLSVGIYNRLVIHTPNRLSGGQETEDTAEPPDEPIN 198
            ..:.:|....:..:|.|||...||.::||.::     .||:..        :.::.|:...:..|
Human   134 DAYKFAGQMGIQLFETSAKENVNVEEMFNCIT-----ELVLRA--------KKDNLAKQQQQQQN 185

  Fly   199 LAGKDRQRAKDSNTCC 214
            ...|..:.:|....||
Human   186 DVVKLTKNSKRKKRCC 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab9Fb	NP_727472.1	Rab	8..165	CDD:206640	74/156 (47%)
RAB35	NP_006852.1	Rab35	3..201	CDD:133310	83/209 (40%)
		Switch 1. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	30..42		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	64..80		8/15 (53%)