DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and MYO1

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_011888.1	Gene:	MYO1 / 856418	SGDID:	S000001065	Length:	1928	Species:	Saccharomyces cerevisiae

Alignment Length:	1822	Identity:	430/1822 - (23%)
Similarity:	744/1822 - (40%)	Gaps:	424/1822 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLD 164
            || |.|:.:..|          :....|||...:|.||                 ..||:|:.|.
Yeast    48 HP-LDSTEVSNL----------VQVRISDVFPVNPSTF-----------------DKVENMSELT 84

  Fly   165 DLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGR------------P 217
            .|:|.|:|:||..|||..||||::|..|:|:|||... :.|..:....|..:            .
Yeast    85 HLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNL-NLYSEDHINLYHNKHNRLSKSRLDENS 148

  Fly   218 LGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGG------SA 273
            ...||||:|||...|:..|.|   .|.::::||||:||||:||.::||||::..|..      |.
Yeast   149 HEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSG 213

  Fly   274 SAVITE---QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIV 334
            |:::..   :||::.|:||:||||:|.||:|||||||::::.| :.|.|.||.|..|||||||||
Yeast   214 SSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIV 278

  Fly   335 TQAPGERNYHVFYELLGGLSETERSKYGLLEAD--KYFYLNQGATDCASGRVDWES---LQGAMQ 394
            .|...|||||:||:||.||.::|.....|...:  .|..|:....|...|..|.|:   |..|:.
Yeast   279 HQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALN 343

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE-------IKWAAHLLHISA 452
            ::|.|:.:...|.:|:|.:|.:||:.|             |...||       :......|.:..
Yeast   344 IIGFSKDQIRWIFQVVAIILLIGNIEF-------------VSDRAEQASFKNDVSAICSNLGVDE 395

  Fly   453 DGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR 517
            .....|:....::|..|.:.......||....:|.::.||..||.::|..||..:..|.. ..:.
Yeast   396 KDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSA-TLNY 459

  Fly   518 ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPV-I 581
            |.:|||.|||....||||||||||.||.||.:||.|:|.|||:||.:|.::|..:.:..:|.: |
Yeast   460 IGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTI 524

  Fly   582 HLLAKK--PVGICHLLDDESNFPRATDLSFLEKC----HYNHALSELYARPRIGAQEFGVTHYAG 640
            .|:..|  |.|:..|||:|:..|::||.||..|.    ..|   |..:.|.|: ...|.:.||||
Yeast   525 DLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQN---SSKFKRSRL-KNGFILKHYAG 585

  Fly   641 QVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRT 705
            .|.|.|:|:|.||:|.|..::|.||:||:..::.:|. |...::.:...:....:.:.|....||
Yeast   586 DVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLF-QPEGEKSSSAGVEANISNQEVKKSART 649

  Fly   706 ---PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQ 767
               .|.::|..:....||..:...||.|||||.||..|.....:...:|.|||..|:|:.|::.:
Yeast   650 STFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAR 714

  Fly   768 RGYPVRLRFQHFVERYRHLLP---------SPLARGTPYRELCRALLEAMPRTGVEGPDYQLGAT 823
            .|||.|:.||.|.:|||.|.|         |.|...|  ::.|..||.::.   ::...|::|.|
Yeast   715 EGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKAST--KQNCEFLLTSLQ---LDTKVYKIGNT 774

  Fly   824 RVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR--- 885
            ::|.:..:...||..:..:|....:.:...:||..||:::........:.:......|...|
Yeast   775 KLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVK 839

  Fly   886 -------YERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQ---------------- 927
                   :.|::....::..:.|.::...::.:|::|.:..:..::..:
Yeast   840 EDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDL 904

  Fly   928 ----------------RAREAREAKQ-----AVLERSQLS--YLDIPAELAFIYSKLQGWSPPHG 969
                            |.:.:.|..|     .|.|:.::|  .|::...|...:.|:||......
Yeast   905 LNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIR 969

  Fly   970 DR------------HLVKVLGTVPGPPS-----------SAVQLPEDLGQFS---FGKFSSVYCN 1008
            :|            .|:|.:..:....|           |.::|..::.:..   ..|...:...
Yeast   970 EREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSF 1034

  Fly  1009 GLRLQPRREPITAPLLT--------------------RAASRDQDFQDALAVFKLILRWSNDKAL 1053
            ..:|....|.:...|:|                    ...|::::|:...|.....|: :.:..|
Yeast  1035 NDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLK-NKESEL 1098

  Fly  1054 EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRL--------WQLLGQCLCC 1110
            ...|||:  |....:..:....||:.:.:     ||......:.||:        :|.:.:....
Yeast  1099 LKMKEKI--DNHKKELATFSKQRDDAVSE-----HGKITAELKETRIQLTEYKSNYQKIKEEYSN 1156

  Fly  1111 FQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRG 1175
            ||......:...|   :...|||....:::|
Yeast  1157 FQRETKEQEQKKR---NSLVESLNDSKIKEL---------------------------------- 1184

  Fly  1176 CDMALPLTLPDEA--SQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVM 1238
                       ||  ||.::::.:.: :..:..:|.:...::|..|...||.....|.....|.:
Yeast  1185 -----------EARLSQEISLNQYLN-KRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDL 1237

  Fly  1239 DLI-------AEKELCPAFPAPRSDLLRSGAKFARTTLPDA-------------VKR------PA 1277
            .|.       .|.|:     ..:.:|: |..:|..|.|..:             :|:      |:
Yeast  1238 QLAFTEITRNLENEI-----EEKKNLI-SRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPS 1296

  Fly  1278 VP------PPAPPTSSGKEDVPR--------------ERRSSRELLSRSSALNERYFEREPSPGP 1322
            :|      .|.......:.|:.:              |.|:..:..:..|||:.::.:.:
Yeast  1297 IPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQ----- 1356

  Fly  1323 GQGSSTGQ---------AKSRSKSLDDLL------------AGDIVPVPTDCDSQEPLHTLGLSE 1366
            |:.|.:..         ::.|.|||:|.|            .|||:   .:.||        :|:
Yeast  1357 GESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLPVGDII---KNRDS--------ISK 1410

  Fly  1367 SRLNDRYHSAE--RLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATR-SSAMSDT 1428
            .....||:..|  :|..:..::..:..:.....|:|        .||.|..:|...| ...:..|
Yeast  1411 YEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQS--------KSKEALLSEQLDRLQKDLEST 1467

  Fly  1429 SEAPSLASHVRRVRVPSQASDVDQFLDDL---------FSPVLDGSLDELSDARSLAASIRGGSY 1484
            .....|.|..    :..|....:..:|||         ....|..:.:::.:..|:...::..:.
Yeast  1468 ERQKELLSST----IKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNK 1528

  Fly  1485 EQEN---EAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIE 1546
            ::|.   |.|.|.:|.|..:.:....:..||:::|:.| |.||.:            ::..|.:|
Yeast  1529 QKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILS-DDLAHL------------KERLSAVE 1580

  Fly  1547 DLDDY---INELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGA--DPLLHQL------MQLP 1600
            |...|   ||.|.|.:..:...:....||...:..:...||:.:.|  ..||.||      :::.
Yeast  1581 DRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEML 1645

  Fly  1601 GETESGPALYQQQVQRAF---------LQSAMAQNLQIQQQLLAQ-NQALQTLLSQQAAAAAANN 1655
            ...:...:|.::::.:.:         |:..:....:|:|:|.:. ||....|   |.:.||.::
Yeast  1646 NNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDAL---QISNAALSS 1707

  Fly  1656 ST 1657
            ||
Yeast  1708 ST 1709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	255/735 (35%)
		MYSc_Myo15	169..828	CDD:276838	249/714 (35%)
		MyTH4	1014..1171	CDD:295320	26/184 (14%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	422/1799 (23%)
MYO1	NP_011888.1	Smc	1534..>1890	CDD:224117	42/192 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910