DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo10A and YPR089W

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_015414.2	Gene:	YPR089W / 856204	SGDID:	S000006293	Length:	888	Species:	Saccharomyces cerevisiae

Alignment Length:	327	Identity:	66/327 - (20%)
Similarity:	116/327 - (35%)	Gaps:	99/327 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2402 PAALQLNLRNGKH-------LALHAARAAAIQS--MVTTFVQEFRKSQSKASTLSSGARAAAQTL 2457
            |:.|| .|.|..|       .::|....:.|.|  :..|.:|:.:::..|            :..
Yeast   389 PSVLQ-ELINTIHSIIIELTSSIHCRLISLIDSTLLAYTTIQDVKQTLYK------------RDW 440

  Fly  2458 NVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDA 2522
            |...:|.:::....::|.       :|.::.|:.|||       ::.|.|::|::::.||...|:
Yeast   441 NFFKKRKQAKLLLKEKNR-------KQLKEQQKKELH-------RKSQGQENHEEEEGQQDGNDS 491

  Fly  2523 MEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQ-QPSSLTNGQVH-------- 2578
              :...:|:........|         |..::...|....|...| :||.|...|:.
Yeast   492 --DDRASTNDDNNSSVSL---------FYDKEILRHLYPPSFEEQMKPSPLKIVQIFGALSYVLN 545

  Fly  2579 -HQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRH-- 2640
             ||...:.|||..|       :..|:                    ||...| |..|:|..:.
Yeast   546 LHQTHPIFQQQCLS-------ISVNW--------------------FATTLF-NKILKDKKKRSL 582

  Fly  2641 HERHQSAANRSYAELVKW-QGHAIRLPLLRLPNDLA----PLALECFDCILRYCGDIPL-DPDLT 2699
            ...|......:.:.|..| |.:...:|...|.:|..    |:.|      :|..|:|.| ||.|.
Yeast   583 SRAHAIQIRLNLSTLESWIQNNDFCVPKPMLIDDFMWQRFPMTL------IRDVGEIDLSDPILR 641

  Fly  2700 EV 2701
            .|
Yeast   642 NV 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580
		MYSc_Myo15	169..828	CDD:276838
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
YPR089W	NP_015414.2	Ank_2	67..152	CDD:423045
YPR089W	NP_015414.2	Myo5p-like_CBD_DIL_ANK	275..776	CDD:271257	66/327 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000