Protein Alignment Myo10A and MYO5

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1419
• Identity: 381/1419 - (26%)
• Similarity: 596/1419 - (42%)
• Gaps: 355/1419 - (25%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK---MFPDAYGLEVAKQYAGRP 217
            ||.|:|||..:.:.::..||:.|:....|||:.|.:||:|||::   ::.||    |..:|.|:.
Yeast    37 GVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDA----VMNEYKGKN 97

  Fly   218 LGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITE 279
            ...:|||:|||..:.:..:.|   .|.|:||||||:||||:.|.:|||:||.......:...|.:
Yeast    98 RLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTESIGKIKD 162

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSG-AIVGAKITQYLLEKSRIVTQAPGERNY 343
            .:|...||||:||.|:|.||:||||.|||||:.|.:. ......||.|||||.|:|:|...|||:
Yeast   163 MVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKNERNF 227

  Fly   344 HVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV-----DWESLQGAMQVLGVSEGER 403
            |:||:...|.|:..|..:|:.:.::|.|  ..|..|.|...     |::....||:|:|:.:.|:
Yeast   228 HIFYQFTKGASDAYRQTFGVQKPEQYVY--TAAAGCISAETIDDLQDYQETLKAMRVIGLGQEEQ 290

  Fly   404 EGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEA-- 466
            :.|.|:|||:|.:|||.|    :.:.:...:|...:...:.|:||.|.:..|.::|..|..|.
Yeast   291 DQIFRMLAAILWIGNVSF----IENEEGNAQVRDTSVTDFVAYLLQIDSQLLIKSLVERIMETNH 351

  Fly   467 ---RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQK-GGTHDAHRISILDIFGFE 527
               |....|.||.|.||...|||.|||:|..||:|:|||:|..:|. .|...:  |.||||:|||
Yeast   352 GMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKS--IGILDIYGFE 414

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL-AKKPVGI 591
            ....|||||:||||.||.||..|.:...|.||..|.||:::|||:.:.||..|..|: |::|.||
Yeast   415 IFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLIEARRPPGI 479

  Fly   592 CHLLDD-------ESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVD 647
            ...::|       :||   |.|.:|.::      |:.....|.  :.:.:|.:.||||.|.|.:|
Yeast   480 FAAMNDSVATAHADSN---AADQAFAQR------LNLFTTNPHFDLRSNKFVIKHYAGDVTYDID 535

  Fly   648 GFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARF 712
            |..|||:|.|:.|::||:.::....:..:...         |:.:.|       |.|.||...:.
Yeast   536 GITDKNKDQLQKDLVELIGTTTNTFLATIFPD---------TVDRES-------KRRPPTAGDKI 584

  Fly   713 ADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQ 777
            ..|...|::::.:..|.::|.||||:.|.....|...||.|::|||:.:.::||:.|:..|..|:
Yeast   585 IKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFE 649

  Fly   778 HFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EALHRALESG 838
            .||||:..|.|.....|  |...:...|:...:..:.:...:||||.|.||::  |.|. |||..
Yeast   650 KFVERFYLLSPHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLF-ALEHM 713

  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGR 903
            |.......|..:||     ..||.|.||..|||::|...|.::...:||:||.   ...::..||
Yeast   714 RDRYWHNMAARIQR-----AWRRFLQRRIDAATKIQRTIRERKEGNKYEKLRD---YGTKVLGGR 770

  Fly   904 QARRRVQQL-----RSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQG 963
            :.||.:..|     ..|:....|::           :|.|.::|.    :.|..::.|..
Yeast   771 KERRSMSLLGYRAFMGDYLSCNESK-----------SKGAYIKRQ----VSIKEKVIFSI----- 815

  Fly   964 WSPPHGD-------RHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
                ||:       |...::..|....|::...:.:.|.|.:.     .|....::..|.  |.|
Yeast   816 ----HGEALHTKFGRSAQRLKKTFLLTPTTLYIVGQTLVQNAM-----TYTQDYKIDVRN--IQA 869

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSS-RGLRDEILVQLCN 1085
            ..||       :.||.....||        |..|..:.|:..|...:.::. :.|.|:|.:::.:
Yeast   870 VSLT-------NLQDDWVAIKL--------ASSGQPDPLINTYFKTELITHLKRLNDKIQIKIGS 919

  Fly  1086 QV-----------------------------------HGLPPN--------------------SG 1095
            .:                                   .|.|||                    |.
Yeast   920 AIEYQKKPGKLHSVKCQINESAPKYGDIYKSSTISVRRGNPPNSQVHKKPRKKSSISSGYHASSS 984

  Fly  1096 EATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACR 1160
            :|||  :.:........|:|..|::      .:.|....|                |.....|.|
Yeast   985 QATR--RPVSIAAAQHVPTAPASRH------SKKPAPPPP----------------GMQNKAATR 1025

  Fly  1161 SFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDG 1225
            ..||            :.|..||.....::.....:.|....||..|.:::|           .|
Yeast  1026 RSVP------------NPASTLTASQSNARPSPPTAATRATPAATPAAAAMG-----------SG 1067

  Fly  1226 QQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKE 1290
            :|..                    .|.|                         |||.||:|..||
Yeast  1068 RQAN--------------------IPPP-------------------------PPPPPPSSKPKE 1087

  Fly  1291 DVPRERRSSRELLSRSSALNERYFERE-PSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCD 1354
            .:                     ||.. ..||.|..|..           .|..||::.:    .
Yeast  1088 PM---------------------FEAAYDFPGSGSPSEL-----------PLKKGDVIYI----T 1116

  Fly  1355 SQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRS---------------HAAS 1404
            .:||   .|.|..:|.|  .|.|...|..      |.| .|:|..:               ::..
Yeast  1117 REEP---SGWSLGKLLD--GSKEGWVPTA------YMK-PHSGNNNIPTPPQNRDVPKPVLNSVQ 1169

  Fly  1405 HGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPS--QASDVDQFLDD 1456
            |.:.|:.....|..|:....:     |.:||:...::|:.|  :.::.|:..||
Yeast  1170 HDNTSANVIPAAAQASLGDGL-----ANALAARANKMRLESDDEEANEDEEEDD 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	244/688 (35%)
		PTZ00121	<828..>943	CDD:173412	32/121 (26%)
		MyTH4	1014..1171	CDD:470587	34/212 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	10/66 (15%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	373/1380 (27%)