Protein Alignment Myo10A and MYO3

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1509
• Identity: 394/1509 - (26%)
• Similarity: 592/1509 - (39%)
• Gaps: 442/1509 - (29%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |:.|:|||..:.:.|:..||:.|:..|:|||:.|.:||:|||::.. ..|...|.:.|.|:....
Yeast    37 GISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDL-GIYTNAVLESYKGKNRLE 100

  Fly   221 LPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||:|||..:.:..|.|   .|.|:||||||:||||:.|.:|||:||.......:...|.:.:|
Yeast   101 VPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVL 165

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSG-AIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ...||||:||.|:|.||:||||.|||||:.|.|. ......||.|||||.|:|.|...|||:|:|
Yeast   166 ATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIF 230

  Fly   347 YELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV-----DWESLQGAMQVLGVSEGEREGI 406
            |:...|.|:|.:..:|:...::|.|  ..|..|.:...     |:|....||:.:|:.:.|::.|
Yeast   231 YQFTKGASDTYKQMFGVQMPEQYIY--TAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQI 293

  Fly   407 VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEA----- 466
            .|:|||:|.:||:.|    :.:.:...:||..:...:.|:||.:.|..|.:.|..|..:.
Yeast   294 FRMLAAILWIGNISF----IENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMK 354

  Fly   467 RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAE 531
            |....|.||...||...|||.|||:|..||:|:|.|:|..:|.....| ..|.||||:|||....
Yeast   355 RGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGAD-KSIGILDIYGFEIFEH 418

  Fly   532 NSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL-AKKPVGICHLL 595
            |||||:||||.||.||..|.:...|.||..|.||:::|||:.:.||..|..|: ||.|.||...:
Yeast   419 NSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAM 483

  Fly   596 DD-------ESNFPRATDLSFLEKCH-YNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDK 652
            :|       :||   |.|.:|.::.: :|   |..|...|  |.:|.:.||||.|.|.::|..||
Yeast   484 NDSIATAHADSN---AADQAFAQRLNLFN---SNPYFELR--ANKFVIKHYAGDVTYDINGITDK 540

  Fly   653 NRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQ 717
            |:|.|:.|::||:.::....:..:...     |..|           ..|.|.||...:...|..
Yeast   541 NKDQLQKDLIELIGTTTNTFLSTIFPD-----DVDK-----------DSKRRPPTAGDKIIKSAN 589

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            :|::::.:..|.::|.|||||.|.....|...||.|::|||:.:.::||:.|:..|..|:.||||
Yeast   590 ELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVER 654

  Fly   783 YRHLLPSPLARGTPYR------ELCRALL-EAMPRTGVEGPDYQLGATRVFLR--EALHRALESG 838
            : :||....:....|.      |..:.:| :||    :...::|||.|.||::  |:|. |||..
Yeast   655 F-YLLSPDCSYAGDYTWDGDTLEAVKLILRDAM----IPEKEFQLGVTSVFIKTPESLF-ALEDM 713

  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGR 903
            |.:.....|..:||     ..||.|.||..||.::|...|.::...:|.:||.   ...:|..|:
Yeast   714 RDKYWYNMAARIQR-----AWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRD---YGTKLLAGK 770

  Fly   904 QARRRVQQL-----------------RSDHRRRQ------------------EAREAAQRAR--- 930
            :.||.:..|                 :..:.|||                  :...:|||.:
Yeast   771 KERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKVF 835

  Fly   931 -----------EARE----------------AKQAVLERSQ------------------------ 944
                       :.||                .||..|...|
Yeast   836 ILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKT 900

  Fly   945 --------------------LSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPP--SSA 987
                                :.|...|.:|..:.||:...:|.:||.:....:....|.|  |.:
Yeast   901 ELMTRLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKS 965

  Fly   988 VQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKA 1052
            .:.|::.|..|                                                   .|.
Yeast   966 NKKPKNPGGLS---------------------------------------------------GKP 979

  Fly  1053 LEGAKEKLLADYIVHKAL-----SSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQ 1112
            ::..|.|       ||:.     |.|..||....|.......:.|.|..||
Yeast   980 IKSKKSK-------HKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAAT-------------- 1023

  Fly  1113 PSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCD 1177
              ||.:.|      :..|:...|:             .|.|:.|....|
Yeast  1024 --AAQAAY------NPKPDKTVPI-------------KSSAIPAAKVSS---------------- 1051

  Fly  1178 MALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV-ASRGWTLVLDDGQQLTDSCGLDYVMDLI 1241
               ..:....:.:.|||...:|..::::...:.:.: .|:|
Yeast  1052 ---KHSSKPSSKEKVAVKKASSSHKSSSAKQNQVSMPPSKG------------------------ 1089

  Fly  1242 AEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRS 1306
            .||...|         |:.....|...:|       :|||.||....|:  |:
Yeast  1090 VEKNKEP---------LKETTATATANIP-------IPPPPPPMGQPKD--PK------------ 1124

  Fly  1307 SALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLND 1371
                   || .....||.|||         |...|..||||.:..|    ||   .|.|.::|.|
Yeast  1125 -------FE-AAYDFPGSGSS---------SELPLKKGDIVFISRD----EP---SGWSLAKLLD 1165

  Fly  1372 -------------RYHSAERLAPV---GKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYAT 1420
                         .|.......||   |.......|||........:|..|....
Yeast  1166 GSKEGWVPTAYMTPYKDTRNTVPVAATGAVNDVTNQKSSQIDNTISSAQEGVQFG---------- 1220

  Fly  1421 RSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYE 1485
             |:.:..||:              :|::.|..|.|.|              |.:|||  |.....
Yeast  1221 -SATVGPTSD--------------NQSNPVGTFSDGL--------------ASALAA--RANKMR 1254

  Fly  1486 QENEAESEIDDLDD 1499
            .|:..:.:.||.||
Yeast  1255 AESADDDDNDDGDD 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	248/688 (36%)
		PTZ00121	<828..>943	CDD:173412	37/181 (20%)
		MyTH4	1014..1171	CDD:470587	23/161 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	7/67 (10%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	390/1497 (26%)