Protein Alignment Myo10A and MYO4

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_009373.1
• Gene: MYO4 / 851204
• SGDID: S000000027
• Length: 1471
• Species: Saccharomyces cerevisiae
• Alignment Length: 871
• Identity: 297/871 - (34%)
• Similarity: 454/871 - (52%)
• Gaps: 110/871 - (12%)

  Fly    86 SLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQ 150
            |.|:.:|       ||.||                         :.|:|...
Yeast    51 SFENDDD-------HPTLP-------------------------VLRNPPIL------------- 70

  Fly   151 DLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAG 215
                ...:|:|.|..|:|.::|..::.||..|.|||::|.:|||.||:......|..|:.:.|:.
Yeast    71 ----ESTDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSS 131

  Fly   216 RPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV- 276
            :....|.||||||...|:..:   .:.|.||:|||||:|||.|.|.:|:|.|:|.........|
Yeast   132 KRKDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVE 196

  Fly   277 ---ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQA 337
               |..|||...|::||||||:|.||||||||||||::.| ::..|.|:||..|||||||:|.|.
Yeast   197 MSQIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQP 261

  Fly   338 PGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD----WESLQGAMQVLGV 398
            ..|||||:||::|.||.|..:.:..|.....|.|.|||.....:| :|    ::....|:.::|:
Yeast   262 ETERNYHIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAG-IDEAREYKITTDALSLVGI 325

  Fly   399 SEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE-IKWAAHLLHISADGLHRALTSR 462
            :...:.||.::||.:||:||:     :::..:....:.|:.: ::.|..||.|......:.:..:
Yeast   326 NHETQLGIFKILAGLLHIGNI-----EMKMTRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKK 385

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV------QKGGTHDAHRISIL 521
            ....|:|::.|.|..:|||.|||:.||.:|:.||:|||..||..:      |:  .|....|.||
Yeast   386 QIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQ--DHVFSFIGIL 448

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||:|||...:|||||.|||||||.||..||:|||||||.||.:|.:||:.:.:.||.|.|.|:..
Yeast   449 DIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIEN 513

  Fly   587 KPVGICHLLDDESNFPRATDLSFLEKCH--YNHALS-ELYARPRIGAQEFGVTHYAGQVWYCVDG 648
            | :||..|||:||..|..:|.|:..|.:  :|...| |::::||.|..:|.|:|||..|.|.|:|
Yeast   514 K-LGILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFGQTKFIVSHYAVDVEYEVEG 577

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGEL--TKQLRAQRDAGKTLPKGSNGRFVTMKP-----RTP 706
            |::||||::....|::..::..|:..::  .::||:. ||    |:..|.....|.|     :.|
Yeast   578 FIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRSD-DA----PEEQNTEKKIMIPARLSQKKP 637

  Fly   707 TVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYP 771
            |:.:.|..||.:|:..:...:..::||||||.||.....|...||.|||..|:|:||:|...|:|
Yeast   638 TLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFP 702

  Fly   772 VRLRFQHFVERYRHLLPSPLARGTPYR---------ELCRALLEAMPRTGVEGPDYQLGATRVFL 827
            .|..|..||:||..|....|..|..|.         ..|:::|:|   |..:...||:|.|::|.
Yeast   703 SRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILDA---TISDSAKYQIGNTKIFF 764

  Fly   828 REALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR--YERLR 890
            :..:...||..||.::....:.:|:.:|....|.|..:...:..:.|::.|....:.|  :|...
Yeast   765 KAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKT 829

  Fly   891 KGALTAQ----RLWRGRQARRRVQQL 912
            :.|:..|    .||:....|..:.|:
Yeast   830 RAAILLQTNIRALWKREYYRAAIGQI 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	265/696 (38%)
		PTZ00121	<828..>943	CDD:173412	18/91 (20%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	297/871 (34%)