Protein Alignment Myo10A and XIA

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_171954.1
• Gene: XIA / 839480
• AraportID: AT1G04600
• Length: 1730
• Species: Arabidopsis thaliana
• Alignment Length: 1757
• Identity: 448/1757 - (25%)
• Similarity: 711/1757 - (40%)
• Gaps: 452/1757 - (25%)

  Fly   120 KRLSTLCS--DVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKG 182
            :.::..||  .|:|:....:...|         :....||:|||.|..|||..:|.||:.||:..
plant    33 EEITVNCSGKTVVAKLNNVYPKDP---------EFPELGVDDMTKLAYLHEPGVLLNLKCRYNAN 88

  Fly   183 LIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPS---PQVVVI 244
            .|||:.|:|||||||:|..|..||.|..|||.|...|.|.||.||:..:|:..:.:   .|.:::
plant    89 EIYTYTGNILIAVNPFKRLPHLYGSETMKQYKGTAFGELSPHPFAVADSAYRKMINEGVSQAILV 153

  Fly   245 SGESGSGKTESTKLVMQYLAAVVPGGGSASA---VITEQILEAAPLLEAFGNARTARNDNSSRFG 306
            |||||:|||||||::|||||.:   ||.|.:   .:.:|:||:.|:|||||||:|.||:||||||
plant   154 SGESGAGKTESTKMLMQYLAYM---GGRAESEGRSVEQQVLESNPVLEAFGNAKTVRNNNSSRFG 215

  Fly   307 KYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYF 370
            |::|:.| :.|.|.||.|..||||:||:...:..|||||.|| :|....|.|..:|.|.:...:.
plant   216 KFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFY-MLCAAPEQETERYKLGKPSTFR 279

  Fly   371 YLNQG---ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEG 432
            ||||.   |.|......::.:.:.||.|:|::..|::||.||:||:|||||:.|.:.:.....|.
plant   280 YLNQSNCYALDGLDDSKEYLATRKAMDVVGINSEEQDGIFRVVAAILHLGNIEFAKGEESEASEP 344

  Fly   433 VEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFN 497
            .:..|...:|.||.|.......|..:|..|....|.|.:...|..|.|...|||.||.:|:.||:
plant   345 KDEKSRFHLKVAAELFMCDGKALEDSLCKRVMVTRDESITKSLDPDSAALGRDALAKIVYSKLFD 409

  Fly   498 WLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEY 562
            |||::||:.:.: ..:..|.|.:|||:|||....|||||.|||..||.||.:||:||||:||.||
plant   410 WLVTKINNSIGQ-DPNSKHIIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEY 473

  Fly   563 ARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR 627
            .:|.::|:.:.:.||..|:.|:.|||.||..|||:...|||:|..:|.:|.:......:.:.:|:
plant   474 TKEEIDWSYIEFIDNQDVLDLIEKKPGGIIALLDEACMFPRSTHDTFAQKLYQTFKNHKRFGKPK 538

  Fly   628 IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPK 692
            :...:|.:.||||.|.|..:.|||||:|.:.|:...||:||....|..|...|  ..::.||
plant   539 LAQTDFTICHYAGDVTYQTELFLDKNKDYVVGEHQALLSSSDCSFVSSLFPPL--PEESSKT--- 598

  Fly   693 GSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDM---PCVLQQL 754
                      .:..::.::|...||.||:|:....|.::||:|||   :.|:.|:   ..:|.||
plant   599 ----------SKFSSIGSQFKQQLQSLLESLSTTEPHYIRCVKPN---NLLKPDIFENINILHQL 650

  Fly   755 RYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQ 819
            |..|:::.|:|...|||.|..|..|:.|:|.|.|..........:.|:.||..:...|     :|
plant   651 RCGGVMEAIRISCAGYPTRKPFNEFLTRFRILAPETTKSSYDEVDACKKLLAKVDLKG-----FQ 710

  Fly   820 LGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ- 883
            :|.|:||||......:::.|.|.|..:|..:||:|.....|::....|||:|.:||..|||.|:
plant   711 IGKTKVFLRAGQMAEMDAHRAEVLGHSARIIQRNVLTYQSRKKFLLLQAASTEIQALCRGQVARV 775

  Fly   884 ----------------------------------------------------------------- 883
                                                                             
plant   776 WFETMRREAASLRIQKQARTYICQNAYKTLCSSACSIQTGMRAKAARIELQLRKKRRATIIIQSQ 840

  Fly   884 -------QRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREA---------------- 925
                   |||.|.:|.|:|.|..||.:.|||.::.|:...:.....::|
plant   841 IRRCLCHQRYVRTKKAAITTQCGWRVKVARRELRNLKMAAKETGALQDAKTKLENQVEELTSNLE 905

  Fly   926 --AQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAV 988
              .|...|..|||...:|..|....||         |||                         :
plant   906 LEKQMRMEIEEAKSQEIEALQSVLTDI---------KLQ-------------------------L 936

  Fly   989 QLPEDLGQFSFGKFSSVYCNGLRLQPR-REPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKA 1052
            :..::..........||..: ::||.| .:...:..::...|..||.|..:......|..:||.|
plant   937 RDTQETKSKEISDLQSVLTD-IKLQLRDTQETKSKEISDLQSALQDMQLEIEELSKGLEMTNDLA 1000

  Fly  1053 LEGAKEKLLADYIVHK------------ALSSRGLRDEILV------------------------ 1081
            .|..:.|.....:.:|            .:|...::||:.|
plant  1001 AENEQLKESVSSLQNKIDESERKYEEISKISEERIKDEVPVIDQSAIIKLETENQKLKALVSSME 1065

  Fly  1082 ----QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLL--LRQ 1140
                :|..:.....||..|.             .:...:|...::..::.| .|.|:.|:  |.:
plant  1066 EKIDELDRKHDETSPNITEK-------------LKEDVSFDYEIVSNLEAE-NERLKALVGSLEK 1116

  Fly  1141 LLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAA 1205
            .:.:.|..::.                   ....|..:....:|.::||    :|:    |....
plant  1117 KINESGNNSTD-------------------EQEEGKYILKEESLTEDAS----IDN----ERVKK 1154

  Fly  1206 LAVSSLGVASRGWTLVLDDGQQLTD-SCGLDYVMD----------LIAEKELCPAFPAP------ 1253
            ||               |:.:.|.| ...|:..:|          .:.|:.|..|..|.
plant  1155 LA---------------DENKDLNDLVSSLEKKIDETEKKYEEASRLCEERLKQALDAETGLIDL 1204

  Fly  1254 RSDLLRSGAKFARTTLPDAVKR-------------PAVP-PPAPPTSSGKED----VPRERRSSR 1300
            ::.:.|...|.:.....:.::|             |.|. ..|||..:|.::    :| .||...
plant  1205 KTSMQRLEEKVSDMETAEQIRRQQALVNSASRRMSPQVSFTGAPPLENGHQEPLAPIP-SRRFGT 1268

  Fly  1301 ELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQ-------EP 1358
            |...||.      .||:|.                         :.|.|...|.|:       :|
plant  1269 ESFRRSR------IERQPH-------------------------EFVDVLLKCVSKNIGFSHGKP 1302

  Fly  1359 LHTLGLSESRLNDRYHSAE------RLAPVGKDTGPRYQKSQHAG-------------RRS--HA 1402
            :..|.:.:..:..:...||      |:.||........:...|..             :||  ..
plant  1303 VAALTIYKCLMRWKIFEAEKTSIFDRIVPVFGSAIENQEDDNHLAYWLTNTSTLLFLLQRSLRQQ 1367

  Fly  1403 ASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRR---VRVPSQ--ASDVDQFLDDLFSPVL 1462
            :|.||..:|......:..|.:....::.:|:|::.|.:   .|.|:.  ...:..:::.::..:.
plant  1368 SSTGSSPTKPPQPTSFFGRMTQGFRSTSSPNLSTDVVQQVDARYPALLFKQQLTAYVETMYGIIR 1432

  Fly  1463 DGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAII 1527
            :....|:|..  |::.|:.   .:|:..:|.:      :|.     |...:.|.|.:|.......
plant  1433 ENVKREVSSL--LSSCIQS---LKESSCDSSV------VNS-----PSKSSEENLPAKSSEENSP 1481

  Fly  1528 KGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPL 1592
            |.....:.|:|...:...:.|.|               |...|||..||.
plant  1482 KKSSEENSPKESSGDKSPQKLSD---------------DNSPSKEGQAVK--------------- 1516

  Fly  1593 LHQLMQLPGETESGPALYQQQ---------------------VQRAFLQSAMAQNLQIQQQLLAQ 1636
                    ...|:.||...|.                     ||:.|.|:....|:|:...||.:
plant  1517 --------SSEENSPASSWQSIIEFLNYILITWKKNYVPLFLVQKMFSQTFQYINVQLFNSLLLE 1573

  Fly  1637 NQ 1638
            .:
plant  1574 RE 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	263/671 (39%)
		PTZ00121	<828..>943	CDD:173412	40/205 (20%)
		MyTH4	1014..1171	CDD:470587	27/199 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	13/77 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
XIA	NP_171954.1	Myosin_N	8..51	CDD:460670	4/17 (24%)
		MYSc_Myo11	75..719	CDD:276835	263/671 (39%)
		PRK02224	<865..>1229	CDD:179385	69/454 (15%)
		MyosinXI_CBD	1278..1699	CDD:271259	60/377 (16%)