DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and XIB

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_171912.2	Gene:	XIB / 839246	AraportID:	AT1G04160	Length:	1500	Species:	Arabidopsis thaliana

Alignment Length:	1251	Identity:	389/1251 - (31%)
Similarity:	580/1251 - (46%)	Gaps:	280/1251 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 SSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPL 218
            :|||||||.|..|||..:|.||:.|||...|||:.|||||||||::..|..|...:..||.|..|
plant    61 ASGVEDMTRLAYLHEPGVLQNLQSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMTQYKGASL 125

  Fly   219 GSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS--AVIT 278
            |.|.||.||:..||:..:.:   .|.:::|||||:||||||||:|:|| |.:.|.|:|:  ..:.
plant   126 GELSPHPFAVADAAYRQMVNEGVSQSILVSGESGAGKTESTKLLMRYL-AFMGGRGAATEGRTVE 189

  Fly   279 EQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERN 342
            :::||:.|:|||||||:|.:|:|||||||::|:.| :||.|.||.|..||||:||:...:..|||
plant   190 QKVLESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDQSGRISGAAIRTYLLERSRVCQVSDPERN 254

  Fly   343 YHVFYELLGGLSETERSKYGLLEADKYFYLNQG---ATDCASGRVDWESLQGAMQVLGVSEGERE 404
            ||.|| :|....|.:..|:.|.:...|.||||.   ..|..:...::.:.:.||.|:|:|..|::
plant   255 YHCFY-MLCAAPEEDAKKFKLGDPKIYHYLNQSKCIQLDAMNDAEEYHATKKAMDVVGISSEEQD 318

  Fly   405 GIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDA--------EIKWAAHLLHISADGLHRALTS 461
            .|.||:|::|||||:.|        .:|.|:.|..        .:|.||.||..:...|..:|..
plant   319 AIFRVVASILHLGNIEF--------AKGTEIDSSIPRDEKSWFHLKTAAELLMCNEKSLEDSLCK 375

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDA-HRISILDIFG 525
            |....|.|.:...|..:.||.:|||.||.:|:.||:|||.:||:.:  |...|: :.|.:|||:|
plant   376 RIMATRDETITKTLDPEAALLSRDALAKVMYSRLFDWLVEKINTSI--GQDPDSKYLIGVLDIYG 438

  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590
            ||....|||||.|||..||.||.:||:||||:||.||.:|.:.|:.:.:.||..::.|:.|||.|
plant   439 FESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYKKEEINWSYIEFVDNQDILDLIEKKPGG 503

  Fly   591 ICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRD 655
            |..|||:...|||:|..:|.:|.:..:...:.:.:|::...:|.:.||||.|.|..:.|||||:|
plant   504 IIALLDEACMFPRSTHETFAQKLYQTYKNHKRFTKPKLARSDFTICHYAGDVTYQTELFLDKNKD 568

  Fly   656 ALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLL 720
            .:..:...||.:|....|..|             .|..|:.   :.:.:..::..||...|..||
plant   569 YVIAEHQALLNASTCSFVANL-------------FPPVSDD---SKQSKFSSIGTRFKQQLVSLL 617

  Fly   721 QSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRH 785
            :.:....|.::||||||........:...||||||..|:::.|:|...|||.|..|..|:.|:..
plant   618 EILNTTEPHYIRCIKPNNLLKPGIFENQNVLQQLRCGGVMEAIRISCAGYPTRKHFDEFLNRFGI 682

  Fly   786 LLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSV 850
            :.|..|.:.:.....|:.||:   :.|:||  ||:|.::||||......|::.|||.|.|:|..:
plant   683 IAPQVLDKNSNEPAACKKLLD---KAGLEG--YQIGKSKVFLRAGQMADLDTRRTEILGRSASII 742

  Fly   851 QRHV------------------------------------------------------------- 854
            ||.|
plant   743 QRKVRSYLAQKTFIQLRISATQIQAVCRGYLARSIYEGMRREAAALKIQRDLRKFLARKAYTELF 807

  Fly   855 ----------RGMLVRRQLA-RRQA-AATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARR 907
                      |||:.|::|. |||. |||.:|.|.|...|:..|.:|:|.|:|.|..|||:.||:
plant   808 SATILIQAGMRGMVSRKELCLRRQTKAATIIQTRCRVYLARLHYRKLKKAAITTQCAWRGKVARK 872

  Fly   908 RVQQLRSDHRRR---QEAREAAQR---------------------AREAREAK-QAVLERSQLSY 947
            .::.|:...|..   |||:...::                     |::...|| ::.||..|..:
plant   873 ELKNLKMAARETGALQEAKNKLEKQVEELTWRLQLEKRMRTDLEEAKKQENAKYESSLEEIQNKF 937

  Fly   948 LDIPAELAFIYSKLQGWSPPHGDRHLVK----VLGTVPGPPSSAVQLPEDL---GQFSFGKFSSV 1005
            .:..|.|.             .:|...|    ||..:...|....:|.|.|   .:...|..||:
plant   938 KETEALLI-------------KEREAAKTVSEVLPIIKEVPVVDQELMEKLTNENEKLKGMVSSL 989

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQD-FQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKA 1069
               .:::..     ||..|...|...|| .:.|||....:.:...  |::..:|| ::|....|.
plant   990 ---EIKIDE-----TAKELHETARISQDRLKQALAAESKVAKLKT--AMQRLEEK-ISDMETEKQ 1043

  Fly  1070 LSSRGLRDEILVQLCNQVHGLPP--------------------------NSGE--ATRLWQLLGQ 1106
            :.   |:..||......|.|.||                          |:|:  |.|..:.:..
plant  1044 IM---LQQTILNTPVKSVAGHPPTATIKNLENGHRTNLENQFNEVEVNGNAGKSAAERQLENVDT 1105

  Fly  1107 CLCCF---------QPSAAFSKY--LMRFVDDEAPESLRPLLLRQLLRQQGGG------------ 1148
            .:.|.         :|.|||:.|  |:.:   :..||.:.....:|:...|..
plant  1106 LIDCVKENIGFSNGKPIAAFTIYKCLLHW---KCFESEKTSAFDRLIEMIGSAIENEDDNGHLAY 1167

  Fly  1149 --TSSGAV-----------GAGACRSFVPAWLEWRAWTRGCDMALPLT--------LPDEASQTV 1192
              |::.|:           ||||..|..|                |:|        |...:|..:
plant  1168 WLTNTSALLFLLQKSLKPAGAGATASKKP----------------PITTSLFGRMALSFRSSPNL 1216

  Fly  1193 AVDSWTSCEEAAALAV 1208
            |     :..|||||||
plant  1217 A-----AAAEAAALAV 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	272/697 (39%)
		MYSc_Myo15	169..828	CDD:276838	260/676 (38%)
		MyTH4	1014..1171	CDD:295320	44/221 (20%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
XIB	NP_171912.2	Myosin_N	11..48	CDD:280832
		MYSc	57..731	CDD:214580	274/702 (39%)
		MYSc_Myo11	76..720	CDD:276835	260/676 (38%)
		IQ	830..852	CDD:197470	9/21 (43%)
		Tropomyosin	877..1053	CDD:278679	41/202 (20%)
		MyosinXI_CBD	1097..1470	CDD:271259	32/155 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810