DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and ATM1

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	1042	Identity:	341/1042 - (32%)
Similarity:	501/1042 - (48%)	Gaps:	199/1042 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QRGGGGSVTPSPAQSPSLALLSPHVLRRQRPASLEDFEDLP-----------------NLSAKHP 101
            :...|.||..:.:..|....|...|.|....|.  |.||.|                 :..|...
plant    31 ENSSGASVRLTNSNVPRKGGLRNGVSRTDTAAG--DSEDSPYSGHGVFVEEQSLTDDVDSGAATM 93

  Fly   102 ALPSSRLRRLK--------------CRYP----QVVKRLSTLCSDVIARHPQTFALQP-GEGSLR 147
            .||.|..||..              .:.|    ::.|.|||...:.:...|:...::. .|..:.
plant    94 PLPQSDERRWSDTSAYARKKILQSWIQLPNGNWELGKILSTSGEESVISLPEGKVIKVISETLVP 158

  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            |..|: ..||:|:..|..|:|.|:|:||..||::.:|||.||.:|:||||:|..| .||....:.
plant   159 ANPDI-LDGVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVP-LYGNRYIEA 221

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAALPSPQV---VVI----------------SGESGSGKTESTKL 258
            |  |...:..||::||...|...:...:|   ::|                |||||:||||:.|:
plant   222 Y--RKKSNESPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSSSGESGAGKTETAKI 284

  Fly   259 VMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAK 322
            .||||||:  ||||.   |..:||:..|:|||||||:|.||||||||||.:|::| :||.|.||:
plant   285 AMQYLAAL--GGGSG---IEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQ 344

  Fly   323 ITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCAS-GRVD- 385
            |..:||||||:|..|.|||:||:||:|..|.|...|.|..|..|.:|.||  |.::|.| ..||
plant   345 IQTFLLEKSRVVQCAEGERSYHIFYQLCAGASPALREKLNLTSAHEYKYL--GQSNCYSINGVDD 407

  Fly   386 ---WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEI------ 441
               :.:::.|:.::.||:.::|.:..:|||||.||||.|   .:...:..||..:|...
plant   408 AERFHTVKEALDIVHVSKEDQESVFAMLAAVLWLGNVSF---TVIDNENHVEPVADESFLFHSLG 469

  Fly   442 KW---------------AAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKAL 491
            .|               .|.|:..:.:.|...|:.|....|.:.:...|.:.||:|||||.||::
plant   470 SWCWKQECLLHNMCLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLTLPQAIDARDALAKSI 534

  Fly   492 YAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFK 556
            |:.||:|||.:||..:..|.......||||||:|||...:|||||.|||||||.||.:||:|:||
plant   535 YSCLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFK 599

  Fly   557 LEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSE 621
            |||.||.::.::||.:.::||...:.|..|||:|:..|||:||.||..|||:...|.. .|..|.
plant   600 LEQEEYIQDGIDWTRVDFEDNQNCLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLK-QHLQSN 663

  Fly   622 LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLAS----------------SRL 670
            ...|...| :.|.|.||||:|.|...|||:||||.|..|.::||:|                |..
plant   664 SCFRGDKG-KLFTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCLLPQAFASSMLIQSEK 727

  Fly   671 PLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIK 735
            |:||.|.|       ||     |::.:.:       :||.:|...|.||:|.:|...|.|:||||
plant   728 PVVGPLYK-------AG-----GADSQRL-------SVATKFKSQLFQLMQRLGNTTPHFIRCIK 773

  Fly   736 PNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYREL 800
            ||..:.....:...||||||..|:|:.                            |.:| ||:..
plant   774 PNNIQSPGVYEQGLVLQQLRCCGVLEV----------------------------LCKG-PYKRF 809

  Fly   801 CRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT----------------------ERL 843
              .::..:.:..:....||:|.|::|.|......||..|.                      :.|
plant   810 --FIIAILHQFNILPEMYQVGYTKLFFRTGQIGVLEDTRNRTLHGILRVQSSFRGYQARCLLKEL 872

  Fly   844 RRAAVSVQRHVRGMLVRRQLA---RRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQA 905
            :|....:|..|||..:|::.|   ||..||..:|::.:.:.|:.:|:.:...::..|...||...
plant   873 KRGISILQSFVRGEKIRKEFAELRRRHKAAATIQSQVKSKIARIQYKGIADASVVIQSAIRGWLV 937

  Fly   906 RR---RVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQ----G 963
            ||   .:..|:|...:..|..|...:|....|.::.|| :::.:..:...|...:..:||    .
plant   938 RRCSGDIGWLKSGGAKTNELGEVLVKASVLSELQRRVL-KAEAALREKEEENDILQQRLQQYENR 1001

  Fly   964 WS 965
            ||
plant  1002 WS 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	278/741 (38%)
		MYSc_Myo15	169..828	CDD:276838	271/720 (38%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	281/752 (37%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	271/720 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810