Protein Alignment Myo10A and XID

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_180882.2
• Gene: XID / 817886
• AraportID: AT2G33240
• Length: 1770
• Species: Arabidopsis thaliana
• Alignment Length: 1742
• Identity: 468/1742 - (26%)
• Similarity: 738/1742 - (42%)
• Gaps: 321/1742 - (18%)

  Fly   110 RLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWN 174
            ::.|:...||.:::       |.||:.             .:....||:|||.|..|||..:|.|
plant    53 KVNCQTKTVVAKVN-------AVHPKD-------------PEFPELGVDDMTKLAYLHEPGVLLN 97

  Fly   175 LRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPS- 238
            |:.||:...|||:.|:|||||||:|..|..||.|:.:||.|...|.|.||.||:..:|:..:.:
plant    98 LKARYNANEIYTYTGNILIAVNPFKRLPHLYGNEIMEQYKGTDFGELSPHPFAVADSAYRKMINE 162

  Fly   239 --PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASA---VITEQILEAAPLLEAFGNARTAR 298
              .|.:::|||||:|||||||::|||||.:   ||.|.:   .:.:|:||:.|:|||||||:|.|
plant   163 GVSQAILVSGESGAGKTESTKMLMQYLAYM---GGKAESEGRSVEQQVLESNPVLEAFGNAKTVR 224

  Fly   299 NDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYG 362
            |:|||||||::|:.|. .|.|.||.|..||||:||:...:..|||||.|| :|....|.|..:|.
plant   225 NNNSSRFGKFVEIQFNHMGRISGAAIRTYLLERSRVCQVSDPERNYHCFY-MLCAAPEQETERYQ 288

  Fly   363 LLEADKYFYLNQG---ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRR 424
            |.:...:.||||.   |.|......::.:.:.||.|:|:|..|::.|.||:||:|||||:.|.:.
plant   289 LGKPSTFHYLNQSNCHALDAIDDSKEYLATRKAMDVVGISPEEQDAIFRVVAAILHLGNIEFAKS 353

  Fly   425 QLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAK 489
            :...|.|..:..|...:|.||.|.......|..:|.:|....|.|.:..||....|..:|||.||
plant   354 EESDGAEPKDDKSRFHLKVAAKLFMCDEKALENSLCNRVMVTRGESITKPLDPGSAALSRDALAK 418

  Fly   490 ALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHV 554
            .:|:.||:|||::||:.:.:..: ..:.|.:|||:|||....|||||.|||..||.||.:||:||
plant   419 IVYSKLFDWLVTKINNSIGQDSS-SKYIIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHV 482

  Fly   555 FKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHAL 619
            ||:||.||.:|.::|:.:.:.||..|:.|:.|||.||..|||:...|||:|..:..||.:.....
plant   483 FKMEQEEYTKEEIDWSYIEFIDNQDVLDLIEKKPGGIIALLDEACMFPRSTHDTLAEKLYQTFGS 547

  Fly   620 SELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQR 684
            .:.:.:|::...:|.:.||||.|.|..:.|||||:|.:.|:...|:.||....|..|..:.|.:
plant   548 HKRFTKPKLARTDFTICHYAGDVTYQTELFLDKNKDYVVGEHQSLMNSSDCSFVSSLFPKSREE- 611

  Fly   685 DAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPC 749
                   ...:.:|       .::.::|...||.||:::....|.::||:|||........:...
plant   612 -------SSKSSKF-------SSIGSQFKQQLQSLLETLNTTEPHYIRCVKPNNVLKPEIFENVN 662

  Fly   750 VLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVE 814
            ||.|||..|:::.|:|...|||.|..|..|:.|:|.|.|....|.....:.|:.||   .|..::
plant   663 VLHQLRCGGVMEAIRISCAGYPTRKPFNEFLTRFRILAPEATERSFDEVDACKKLL---ARVDLK 724

  Fly   815 GPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRG 879
            |  :|:|.|:||||......|::.|.|.|..:|..:||.|...|.|::....|:|:|.:||..||
plant   725 G--FQIGKTKVFLRAGQMAELDAHRAEVLGHSARIIQRKVITYLSRKKYLLLQSASTEIQAFCRG 787

  Fly   880 QRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQ 944
            ..|:.:::..|:.|           |..|:|:....:..:...::....|...:...:|:..|.:
plant   788 HIARVQFKATRREA-----------ASVRIQKQARTYICQTAFKKLCASAISIQSGLRAMAARVE 841

  Fly   945 LSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNG 1009
            ..|.........|.|:::                                         ...|..
plant   842 FQYRTKRKAAIIIQSQIR-----------------------------------------RCLCRR 865

  Fly  1010 LRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRG 1074
            ..|:.::..||.....|.....::.:      ||.:......||:.||.||..:  |.:..|...
plant   866 RYLRTKKAAITTQCGWRVKVAHRELR------KLKMAAKETGALQDAKTKLEKE--VEELTSCLE 922

  Fly  1075 LRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLR 1139
            |..::.::| .||     .:.|...|             .:|.:...::..:.:..:|...|.|:
plant   923 LEKQMRMEL-EQV-----KTQEVEDL-------------RSALNDMKLQLGETQVTKSEEILKLQ 968

  Fly  1140 QLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDE-------ASQTVAVDSW 1197
            ..|:..                    .||:....:..:|...|...:|       :.|....:|.
plant   969 SALQDM--------------------QLEFEELAKELEMTNDLAAENEQLKDLVSSLQRKIDESD 1013

  Fly  1198 TSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGA 1262
            :..||.:.|:...:    :....|:|.|          .::.|.||.:...|..:.....:
plant  1014 SKYEETSKLSEERV----KQEVPVIDQG----------VIIKLEAENQKLKALVSTLEKKI---- 1060

  Fly  1263 KFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSS-RELLSRSSALNERY------FEREPSP 1320
                    |::.|     ....|||...|..:|..|| .|:||..:|.|||.      .|.|...
plant  1061 --------DSLDR-----KHDVTSSNISDQLKESASSDYEMLSNLAAENERLKALVSSLENENYE 1112

  Fly  1321 GPGQGSSTGQAKSRSKSLDDLLAGDI-----VPVPTDCDSQEPLHTLGLSESRLND---RYHSA- 1376
            ..|..|...|.:......:::||.|.     :......::::....:.|.|.::::   :|..|
plant  1113 NDGNDSPNEQKEGPQMLKEEILAEDFSIDDEMTNKLAAENKDLYDLVDLLERKIDETEKKYEEAS 1177

  Fly  1377 ----ERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTS------EA 1431
                |||..| .||..:|:::.............:.:.....|.........:||..      ..
plant  1178 KLCEERLKQV-VDTEKKYEEASRLCEERLKQVVDTETKLIELKTSMQRLEEKVSDMEAEDKILRQ 1241

  Fly  1432 PSLASHVRRVRVPSQASDVDQFLDDLFSPVLDG---SLDELSDARSLAASIRGGSYEQENEAESE 1493
            .:|.:...|...|.::.|:..|: .||.||.:|   |...:...|..|.|.|....||
plant  1242 QALRNSASRKMSPQKSLDLFVFM-YLFQPVENGHHESFAPIPSRRFGAMSFRRSQIEQ------- 1298

  Fly  1494 IDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVAS----------KPEERDEE------ 1542
                        ||...|..|.|..||:  .....|..||:          |..|.::.
plant  1299 ------------QPHEFVDVLLKCVSKN--VGFSHGKPVAAFTIYKCLIHWKLFEAEKTSVFDRI 1349

  Fly  1543 -----SEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSI-RGGGSTDSNGADP---------- 1591
                 |.||:.:|..|..:          .||:...|...: |...|..:.||.|
plant  1350 VPIFGSAIENPEDDSNLAY----------WLTNTSTLLFLLQRSLKSHSTTGASPKKPPQPTSFF 1404

  Fly  1592 -LLHQLMQLPGETE-SGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAAN 1654
             .:.|..:.|.... ||..:  |||      .|....|..:|||.|..:.:..:..:......|
plant  1405 GRMTQGFRSPSSASLSGDVV--QQV------DARYPALLFKQQLTAYIETIYGIFQENVKRKLA- 1460

  Fly  1655 NSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETR 1719
                     |:||| .|......|......|.|:    ||.:...|..|....||.:..:.:.:.
plant  1461 ---------PVLSS-CIQGLKDSSHEFSAETLSA----ESSEQNSPEKPSEENPPEKLSEDNSSG 1511

  Fly  1720 HFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQH 1771
            ...:.|..||         |...:.|...:||:..| |:.:...:..|.|::
plant  1512 KLSEDYLAAK---------PSEDNSPAKPSEENSQA-KLSEVNPQAKPSAEN 1553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	260/668 (39%)
		PTZ00121	<828..>943	CDD:173412	26/114 (23%)
		MyTH4	1014..1171	CDD:470587	26/156 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	14/73 (19%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
XID	NP_180882.2	Myosin_N	25..68	CDD:460670	3/21 (14%)
		MYSc_Myo11	92..736	CDD:276835	260/668 (39%)
		Mplasa_alph_rch	889..>1259	CDD:275316	79/448 (18%)
		MyosinXI_CBD	1298..1739	CDD:271259	65/320 (20%)