DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and XIG

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_179619.2	Gene:	XIG / 816548	AraportID:	AT2G20290	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	946	Identity:	317/946 - (33%)
Similarity:	478/946 - (50%)	Gaps:	151/946 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 VKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGL 183
            :|...|....|:|:...|:   |.:      .::..|||:|||.|..|||..:|.||:.||....
plant    45 IKVQCTSGKTVVAKGSNTY---PKD------MEVPPSGVDDMTTLAYLHEPGVLQNLKSRYYIDE 100

  Fly   184 IYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPS---PQVVVIS 245
            |||:.|:|||||||:|..|:.|...:..||.|..||.|.||.||:..||:..:.:   .|.:::|
plant   101 IYTYTGNILIAVNPFKQLPNLYNDHMMAQYKGAALGELSPHPFAVADAAYRQMINEGISQSILVS 165

  Fly   246 GESGSGKTESTKLVMQYLAAVVPGGGSAS--AVITEQILEAAPLLEAFGNARTARNDNSSRFGKY 308
            ||||:||||:.|::|:|||.:  ||.:.|  ..:.:|:||:.|:|||||||:|.:|:|||||||:
plant   166 GESGAGKTETAKMLMKYLAKM--GGRAVSDRRTVEDQVLESNPVLEAFGNAKTVKNNNSSRFGKF 228

  Fly   309 LEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYL 372
            :|:.| :.|.|.||.|..||||:||:...:..|||||.||.|.....|.:| |..|.:..::.||
plant   229 VEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPPEDKR-KLKLNDPTEFRYL 292

  Fly   373 NQG---ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE-GV 433
            ||.   ..|......::...:.||.::|::..|:|.|.||:||:|||||:.|     ..|:| ..
plant   293 NQSHCIKLDGVDDSKEYTKTREAMGIVGINLEEQEAIFRVVAAILHLGNIEF-----AIGEEPDS 352

  Fly   434 EVGSDAE---IKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGL 495
            .|.:|..   :|.||.|.......|..:|..|......|.:...|..:.|..:|||.||.:|:.|
plant   353 SVPTDESKKYLKIAAELFMCDEQALEDSLCKRIMVTPEETISRCLDPNSAALSRDALAKFVYSRL 417

  Fly   496 FNWLVSRI-NSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            |:|:|::| |||.|...:.|  .|.:|||:|||....|||||.|||..||.||.:|.:||.|:||
plant   418 FDWIVNKINNSIGQDPDSKD--MIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFTQHVLKMEQ 480

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYA 624
            .||.:|.:||:.:.:.||..|:.|:.||..||..|||:...|||:|..:|.:|.:.....::.::
plant   481 EEYTKEEIEWSQITFPDNRYVLELIEKKRGGIIALLDEACMFPRSTHKTFSQKLYETLKDNKYFS 545

  Fly   625 RPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKT 689
            :|::...:|.:.||||.|.|..:.||:||:|.:..:...||.:||...:..|...|  ..||.|
plant   546 KPKLSRTDFTICHYAGDVTYQTEQFLEKNKDYVVAEHQALLGASRCTFIAGLFPPL--VEDANK- 607

  Fly   690 LPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQL 754
                        :.:..::|::|...|..|::.:....|.::||:|||........:....||||
plant   608 ------------QSKFSSIASQFKQQLASLIEGLNTTEPHYIRCVKPNNLLKPSIFENQNSLQQL 660

  Fly   755 RYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQ 819
            |..|:::||::.:.|||.|..|..|::|:..|..:.|.:.:..:..|:.|||.:   |:.|  :|
plant   661 RCGGVMETIRVCRAGYPTRKHFDEFLDRFGILDSATLDKSSDEKAACKKLLETV---GLNG--FQ 720

  Fly   820 LGATRVFLREALHRALESGRTERLRRAA------------------------------------- 847
            :|.|:|||:......|:..|||.|.|||
plant   721 IGKTKVFLKAGQMAELDDRRTEVLGRAACIIQWKFRSYLTRQSFIMLRNAAINIQAVYRGQVARY 785

  Fly   848 --------------------------------VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQ 880
                                            |:||..:|||..|..|.|:..|.|.:|:..|..
plant   786 RFENLRREAAALKIQRALRIHLDRKRSYIEAVVTVQSGLRGMAARVVLRRKTKATTVIQSHCRRL 850

  Fly   881 RAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHR--------------------------RR 919
            ||:..|::|:|.|:|.|..||.|.||:.:::|::|.|                          :|
plant   851 RAELHYKKLKKAAITTQSAWRARLARKELRKLKTDARDTVVLQAAKSMLAEKVEELTWRLDLEKR 915

  Fly   920 QEAREAAQRAREAREAK-QAVLERSQLSYLDIPAEL 954
            ........:|:|  .|| |..||..||.:.:....|
plant   916 MRVDMEVSKAQE--NAKLQLALEEIQLQFEETKVSL 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	262/693 (38%)
		MYSc_Myo15	169..828	CDD:276838	252/672 (38%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
XIG	NP_179619.2	Myosin_N	23..58	CDD:280832	3/12 (25%)
		MYSc	73..740	CDD:214580	263/696 (38%)
		MYSc_Myo11	86..729	CDD:276835	252/672 (38%)
		DUF4200	922..1052	CDD:290574	10/30 (33%)
		MyosinXI_CBD	1112..1463	CDD:271259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810