DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYO15B

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001381987.1 Gene:MYO15B / 80022 HGNCID:14083 Length:3096 Species:Homo sapiens


Alignment Length:3213 Identity:819/3213 - (25%)
Similarity:1245/3213 - (38%) Gaps:909/3213 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 EP---WQRGGGGSVTPSPAQSPSL--ALLSPHVLRRQRPASLEDFEDLPNLSAKHPALPSSRLRR 110
            ||   |.:|.|      |.:.|.|  |:|.|.:....|   |:...|        |.|..| ||.
Human   632 EPPVRWAQGSG------PHEGPRLGAAVLLPRLSLETR---LQQEGD--------PGLRGS-LRE 678

  Fly   111 LKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSG---------VEDMTLLDDL 166
            |.....:         .:.:.......:|:||   |.|....|:.|         :||:..|..:
Human   679 LWEPEDE---------DEAVLERDLELSLRPG---LEAPPFPGAKGRSLGDGLEDMEDLARLRLV 731

  Fly   167 HEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAA 231
            .::|:|..|:.|:..|.||||.|.:|:.:||::..| .:..||...|..|...|..||:|||.|:
Human   732 CDSSVLLCLKKRFHLGRIYTFGGPVLLVLNPHRSLP-LFSPEVQASYHPRKALSTTPHIFAIVAS 795

  Fly   232 AHAALPS----PQVVV----ISGESGSGKTESTKLVMQYLAAVVPG-GGSASAVITEQILEAAPL 287
            |:....:    |.:::    .||.|||||||:.|.:||:|:::... .|:...    |:.:..|:
Human   796 AYDLAQNTGQDPCILLCSSHCSGHSGSGKTEAAKKIMQFLSSLEQDQTGNREC----QVEDMLPI 856

  Fly   288 LEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGG 352
            |.:||:|:|..|.|:||||:...:|.:.|.||||.::.||||.||:|.||..||::||||:||.|
Human   857 LSSFGHAKTILNANASRFGQVFCLYLQQGVIVGASVSHYLLETSRVVFQAQAERSFHVFYKLLAG 921

  Fly   353 LSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQG---AMQVLGVSEGEREGIVRVLAAVL 414
            |...||.:..|...:.|:|||||......|:.|.:..:|   |:|.||:...|...:..||||:|
Human   922 LDSIERERLSLQGPETYYYLNQGQACRLQGKEDAQDFEGLLKALQGLGLCPEELNAVWAVLAAIL 986

  Fly   415 HLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQ 479
            .|||:.|...: |..||...|.|.|||..||.||.:..:.|..|:|.|.||....::...|.::.
Human   987 QLGNICFSSSE-RESQEVAAVSSWAEIHTAARLLRVPPECLEGAVTRRVTETPYGQVSRSLPVES 1050

  Fly   480 ALDARDAFAKALYAGLFNWLVSRINS-IVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYAN 543
            |.|||||.|||||:.||:.|:.|.|: :...|.......::::|.:|||.|..|..||||.|.|:
Human  1051 AFDARDALAKALYSRLFHRLLRRTNARLAPPGEGGSIGTVTVVDAYGFEALRVNGLEQLCNNLAS 1115

  Fly   544 ENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLS 608
            |.|||:.::.:...|:.|..||.|.|.|:........:.||..:|..:..:||.::...:|||.:
Human  1116 ERLQLFSSQMLLAQEEEECRRELLSWVPVPQPPRESCLDLLVDQPHSLLSILDAQTWLSQATDHT 1180

  Fly   609 FLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLV 673
            ||:|.||:|.....||:||:....|.|.||||.|.|.|..||::|||.|...|:|:|..|:|.||
Human  1181 FLQKSHYHHGDHPSYAKPRLPLPVFTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLGQSQLQLV 1245

  Fly   674 GELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQ 738
            |.|.::...|       .:|..||        ||:|:||..:|:.|:..:||.|.:|::|:.||.
Human  1246 GSLFQEAEPQ-------SRGGRGR--------PTLASRFQQALEDLIARLGRSHVYFIQCLTPNP 1295

  Fly   739 EKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRA 803
            .|.....|:..|.:||....:|:.:..|...:|||:.|:.|:..:: .|.|........||.|.|
Human  1296 GKLPGLFDVGHVTEQLHQAAILEAVGTRSANFPVRVPFEAFLASFQ-ALGSEGQEDLSDREKCGA 1359

  Fly   804 LLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQA 868
            :|..:  .|.|.|.|.||||:|.|:|...:.||..|.::..:|.|.:.|.....:      .||.
Human  1360 VLSQV--LGAESPLYHLGATKVLLQEQGWQRLEELRDQQRSQALVDLHRSFHTCI------SRQR 1416

  Fly   869 AATRLQARWRGQRAQQRYERLRKG-------ALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAA 926
            ...|:|||.||.:|::||.|.|..       .|.||.|   .|.|:|:|      ..|.:...::
Human  1417 VLPRMQARMRGFQARKRYLRRRAALGQLNTILLVAQPL---LQRRQRLQ------LGRWQGWHSS 1472

  Fly   927 QRAREAREAKQAVLER---SQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPG--PPSS 986
            :||          |||   .:|..|:||||||.:....:.    |.|.....:...:|.  |...
Human  1473 ERA----------LERVPSMELGRLEIPAELAVMLKTAES----HRDALAGSITECLPPEVPARP 1523

  Fly   987 AVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDF-QDALAVFKLILRWSND 1050
            ::.||.|:..|.|..|.::......|....:|:..||    ...|.|. |.||.:.|::||...|
Human  1524 SLTLPADIDLFPFSSFVAIGFQEPSLPRPGQPLAKPL----TQLDGDNPQRALDINKVMLRLLGD 1584

  Fly  1051 KALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSA 1115
            .:||..:.:::..|:|.:.....|||:|:..||..|: ...|:..::.|.|.|:...|..|.|..
Human  1585 GSLESWQRQIMGAYLVRQGQCRPGLRNELFSQLVAQL-WQNPDEQQSQRGWALMAVLLSAFPPLP 1648

  Fly  1116 AFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRA-WTRGCDMA 1179
            ...|.|::||.|:||..:..|...:||    |......:.:||.|:..|..|||.| |.|| .||
Human  1649 VLQKPLLKFVSDQAPRGMAALCQHKLL----GALEQSQLASGATRAHPPTQLEWLAGWRRG-RMA 1708

  Fly  1180 LPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVAS--RGWTLVLDDGQQLTDSCGLDYVMDLIA 1242
            |.:....|...:..|:|||:.|:.|...:.|.|:.:  |||::.|.......|..|.|:|:|||:
Human  1709 LDVFTFSEECYSAEVESWTTGEQLAGWILQSRGLEAPPRGWSVSLHSRDAWQDLAGCDFVLDLIS 1773

  Fly  1243 EKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSS 1307
            :.|.......|||        :..|.|..|...|..|....|:      :|              
Human  1774 QTEDLGDPARPRS--------YPITPLGSAEAIPLAPGIQAPS------LP-------------- 1810

  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR 1372
                      |.|.||                        |.||                 |..|
Human  1811 ----------PGPPPG------------------------PAPT-----------------LPSR 1824

  Fly  1373 YHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
            .|:.|                                                            
Human  1825 DHTGE------------------------------------------------------------ 1829

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
            |:|      :..:|.|||.:|.||:...|.:|..:.:|::.::||.                .|.
Human  1830 VQR------SGSLDGFLDQIFQPVISSGLSDLEQSWALSSRMKGGG----------------AIG 1872

  Fly  1503 DIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDK 1567
            ...|..|:|     .....|:.|...|...|                        |:|:...:..
Human  1873 PTQQGYPMV-----YPGMIQMPAYQPGMVPA------------------------PMPMMPAMGT 1908

  Fly  1568 LTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQ---VQRAFL----QSAMAQ 1625
            :.:...:.|.           ..|.|..|       ::|....|||   .|:|.:    .:|.|.
Human  1909 VPAMPAMVVP-----------PQPPLPSL-------DAGQLAVQQQNFIQQQALILAQQMTAQAM 1955

  Fly  1626 NLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLV 1690
            :|.::||:  |.:..|...|:.|:.|:.:..||.|..|         |.||:.|.|...:....:
Human  1956 SLSLEQQM--QQRQQQARASEAASQASPSAVTSKPRKP---------PTPPEKPQRDLGSEGGCL 2009

  Fly  1691 VMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAK-TVRIGKWRWPP-----PQDEPQFQT 1749
            ...|.:....|..|        |...:.|::....|:.: |||..|   ||     ||.|.|.:.
Human  2010 RETSEEAEDRPYQP--------KSFQQKRNYFQRMGQPQITVRTMK---PPAKVHIPQGEAQEEE 2063

  Fly  1750 EEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIE-----SPTPPP 1809
            ||:               :.:..|                        ||.|:|     ||.|||
Human  2064 EEE---------------EEEEEQ------------------------EEQEVETRAVPSPPPPP 2089

  Fly  1810 MSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVG 1874
                                                          :.||..:.|..:.|.    
Human  2090 ----------------------------------------------IVKKPLKQGGAKAPK---- 2104

  Fly  1875 KLKLSSEMRQRLEQVTAGHSV-----RSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGN 1934
                .:|.....|....||..     |.||...|:.: |.:.:.:|::               ||
Human  2105 ----EAEAEPAKETAAKGHGQGPAQGRGTVVRSSDSK-PKRPQPSREI---------------GN 2149

  Fly  1935 SGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPS-------- 1991
                       .:|....|                      |.| ||.|..|.|||.        
Human  2150 -----------IIRMYQSR----------------------PGP-VPVPVQPSRPPKAFLRKIDP 2180

  Fly  1992 --------------MAPPAPPPAP-QSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFG 2041
                          .:||...|:| :.||.|.:|.|:...:...|..:||.              
Human  2181 KDEALAKLGINGAHSSPPMLSPSPGKGPPPAVAPRPKAPLQLGPSSSIKEK-------------- 2231

  Fly  2042 AVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASG 2106
                                                                       :||.  
Human  2232 -----------------------------------------------------------QGPL-- 2235

  Fly  2107 SGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRT 2171
                                                        :|..|                
Human  2236 --------------------------------------------LDLFG---------------- 2240

  Fly  2172 HMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGL-------------- 2222
                                 ::|...| |.|||   ||| |.|....||.              
Human  2241 ---------------------QKLPIAH-TPPPP---PAP-PLPLPEDPGTLSAERRCLTQPVED 2279

  Fly  2223 -GVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPC 2286
             ||.:.:|..|||    .|.:|...||||.:|||||.|.|....|..|.||..|:|.|.|..: |
Human  2280 QGVSTQLLAPSGS----VCFSYTGTPWKLFLRKEVFYPRENFSHPYYLRLLCEQILRDTFSES-C 2339

  Fly  2287 LRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARL 2350
            :||:..|:....::|.|..|.:|:|:....|              ||:.:|..||| |..||:|.
Human  2340 IRISQNERRKMKDLLGGLEVDLDSLTTTEDS--------------VKKRIVVAARDNWANYFSRF 2390

  Fly  2351 FAVQGAPLYPDVSIMGVSHSGLYLAR------RDADYLIVVQAISFGEIQSAVTLPRPAALQLNL 2409
            |.|.|.. ..||.::.|||.||.|.:      ...|.|.::.:.||.|: ..|.....:.|:|:|
Human  2391 FPVSGES-GSDVQLLAVSHRGLRLLKVTQGPGLRPDQLKILCSYSFAEV-LGVECRGGSTLELSL 2453

  Fly  2410 RNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLN---------VPLERLE 2465
            :: :.|.||.|||.||:::|..|:.|.:|.......|.|........|:         :|:..||
Human  2454 KS-EQLVLHTARARAIEALVELFLNELKKDSGYVIALRSYITDNCSLLSFHRGDLIKLLPVATLE 2517

  Fly  2466 SRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMAT 2530
            ...      :.|..||        :|.|                         ....:.:...|.
Human  2518 PGW------QFGSAGG--------RSGL-------------------------FPADIVQPAAAP 2543

  Fly  2531 DHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLP 2595
            |....::|:.|..:||                         |:||     |..|.:..:.|:...
Human  2544 DFSFSKEQRSGWHKGQ-------------------------LSNG-----EPGLARWDRASERPA 2578

  Fly  2596 H-------HDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQ--LRDADRHHERHQSAANRS 2651
            |       .|.:|..|...:....|.| ..|::.:||.::||..|  |...|      ..||.:.
Human  2579 HPWSQAHSDDSEATSLSSVAYAFLPDS-HSYTMQEFARRYFRRSQALLGQTD------GGAAGKD 2636

  Fly  2652 YAELVKWQGHAIRLPLLRLPNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLA 2716
            ...||::....|:..||.|.:|::.||:..|..::|:.||........|:..:|.:|..|.:. .
Human  2637 TDSLVQYTKAPIQESLLSLSDDVSKLAVASFLALMRFMGDQSKPRGKDEMDLLYELLKLCQQE-K 2700

  Fly  2717 LRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHG 2781
            ||||:|||::||.|.:  |.|:...|.|..||:|..:|..|..|.|||.:.|..:...:.     
Human  2701 LRDEIYCQVIKQVTGH--PRPEHCTRGWSFLSLLTGFFPPSTRLMPYLTKFLQDSGPSQE----- 2758

  Fly  2782 TAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTVVADVIAE 2846
            .|.....:|::|.:.|||:.:|...|:.|...|::.|..:..||||.:...|.:..||.|:|..|
Human  2759 LARSSQEHLQRTVKYGGRRRMPPPGEMKAFLKGQAIRLLLIHLPGGVDYRTNIQTFTVAAEVQEE 2823

  Fly  2847 LCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFALK 2911
            ||..:|:....|.|||:|:.|.:......||...||:..|..:     |...|...|..|...|.
Human  2824 LCRQMGITEPQEVQEFALFLIKEKSQLVRPLQPAEYLNSVVVD-----QDVSLHSRRLHWETPLH 2883

  Fly  2912 REPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVPVPEMV-RDMARIAALLHRAADLSHVPAMKE 2975
            .:.:   .|:...::||..|||:|.|        ||.... ..:||:|||.|.:....:.|:.::
Human  2884 FDNS---TYISTHYSQVLWDYLQGKL--------PVSAKADAQLARLAALQHLSKANRNTPSGQD 2937

  Fly  2976 IKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRI-- 3038
            :...:||...  |::..|....|:.....::...||.:.:..|:..::..||||.:.:.|.|:  
Human  2938 LLAYVPKQLQ--RQVNTASIKNLMGQELRRLEGHSPQEAQISFIEAMSQLPLFGYTVYGVLRVSM 3000

  Fly  3039 WAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTH--------ETLQHWSFMEVISTRKVRSED 3095
            .|..||            .:|.|||:.::.:||::.        ::||....:..:      .|.
Human  3001 QALSGP------------TLLGLNRQHLILMDPSSQSLYCRIALKSLQRLHLLSPL------EEK 3047

  Fly  3096 GALFLDMKVGNLMQQRVIRVQTEQAHEI 3123
            |...|::..|:....:.|..:..||.|:
Human  3048 GPPGLEVNYGSADNPQTIWFELPQAQEL 3075

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 258/701 (37%)
MYSc_Myo15 169..828 CDD:276838 252/671 (38%)
MyTH4 1014..1171 CDD:295320 48/157 (31%)
MyTH4 2704..2810 CDD:279165 35/105 (33%)
B41 2823..3033 CDD:214604 58/210 (28%)
FERM_B-lobe 2920..3025 CDD:271216 25/105 (24%)
FERM_C_MyoXV 3029..3138 CDD:270022 22/105 (21%)
MYO15BNP_001381987.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 214 1.000 Domainoid score I2741
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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