Protein Alignment Myo10A and PLEKHH3

DIOPT Version :9

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_016880602.1
• Gene: PLEKHH3 / 79990
• HGNCID: 26105
• Length: 882
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 148/614 - (24%)
• Similarity: 223/614 - (36%)
• Gaps: 164/614 - (26%)

  Fly  2604 LQD-ESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPL 2667
            |:| :.:.|.|.:|        |:.:.||..|        ||.|.|  .||            ||
Human   301 LRDIQESCGDPEAV--------ALIYLRNPIL--------RHTSGA--LYA------------PL 335

  Fly  2668 LRLPNDL-------APLALECFDCIL--------RYCGDIPLDPDLTEVKCVYTVLMHCHKYLAL 2717
            |.||..:       |||..|.....|        |..|  ||         :..||..|....||
Human   336 LPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPG--PL---------MQGVLQTCRDLPAL 389

  Fly  2718 RDEVYCQLMKQTTANRSP--CP----DSSQRAWRLLSILAAYFGCSDALRPYLMEHL---TSAAS 2773
            |||::.||.|||:....|  .|    .::.|.|:||:.::..|....|:|.:|:.||   ..|..
Human   390 RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALP 454

  Fly  2774 DRRRSCHGTAAVCLTNLRKT-ARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCS 2837
            |      ...|.....:||. .|..||:.|||:.|::|:|..:.....:: .||.....|.....
Human   455 D------SELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVH-CPGAGACAVAIDSH 512

  Fly  2838 TVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTT--ELLKSGQPFYLI 2900
            |...:|..||...||:  ...:..|:||  .|..|....||....:.||.|  |.|.:.:.....
Human   513 TTAGEVARELVGRLGL--ARSRNAFALY--EQRGAQERALAGGTLVADVLTRFENLAAEEAGLED 573

  Fly  2901 FCRSVWHFALKREPAPMPLYVEVLFNQVAPD-------YLEGLLLELPGNGVPVPEMVRDMA--R 2956
            ...|.|...|:...   ||:.|.|    :||       :.:...|.|.|...|..:.:|.:|  |
Human   574 SPDSGWRLCLRLHG---PLHPEGL----SPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALR 631

  Fly  2957 IAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRP---------------AQW----------- 2995
            :.:|   ..|.|....:..:..|||.|| ..||..|               |.|
Human   632 LQSL---QRDFSPRVPLPRLDRLLPPPA-PPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAER 692

  Fly  2996 -----------------------VGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKR 3037
                                   ...|...|.::..:...:..|.:|.:.|..|.||::.:.|..
Human   693 ARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLE 757

  Fly  3038 IWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDM 3102
            :..|.|     ..:|  :.|.|.|..:.:....|...|.:...|:..|.:.:.:    |...|.:
Human   758 LSTEPG-----RGAP--QKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLM----GPHTLAL 811

  Fly  3103 KVGNLMQQRVIRVQTEQAHEISRLVRQYI 3131
            :||    :..:.:|:.|..||.:||..|:
Human   812 RVG----ESQLLLQSPQVEEIMQLVNAYL 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580
		MYSc_Myo15	169..828	CDD:276838
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165	37/115 (32%)
		B41	2823..3033	CDD:214604	58/269 (22%)
		FERM_B-lobe	2920..3025	CDD:271216	29/162 (18%)
		FERM_C_MyoXV	3029..3138	CDD:270022	23/103 (22%)
PLEKHH3	XP_016880602.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810