DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myhz1.2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_005171981.1 Gene:myhz1.2 / 799300 ZFINID:ZDB-GENE-070705-73 Length:1937 Species:Danio rerio


Alignment Length:2199 Identity:493/2199 - (22%)
Similarity:835/2199 - (37%) Gaps:602/2199 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
Zfish    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA 152

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|::...|:..:.:.   |.|:|:||||:|||.:||.|:||.|.|...|         |...
Zfish   153 PPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQAAGKMQ 217

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||:|||:|.||||||||||::.::| .||.:..|.|..|||||||:..|.|
Zfish   218 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLP 282

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQ 394
            .||.||:||:::.. .:.|..:..|:..:.|.:     ..|:.|::      |.|.|   ..|:.
Zfish   283 DERGYHIFYQMMTN-HKPELIEMTLITTNPYDF-----PMCSQGQITVASIDDKEELVATDTAID 341

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            :||.:..|:.||.:...||||.||:.|.::|   .:|..|.....|.....:||.:::..:.:||
Zfish   342 ILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKIGYLLGLNSADMLKAL 403

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|..::..|.:|::|..:|.|:|.|||.::......:.. |.:|||.
Zfish   404 CYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFF-IGVLDIA 467

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:.|..:.:..:|.....|.:||:
Zfish   468 GFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL 532

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDG 648
            ||..:|::|..||:|||.||..|.:..| |.:..|    :|..|..|  |.:.||||.|.|.:.|
Zfish   533 GIFSILEEECMFPKATDTSFKNKLYDQH-LGKCNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISG 596

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            :||||:|.|...|::|...|.:.|:..|...:..:...||   ||...:..:|:    ||:::|.
Zfish   597 WLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGK---KGGKKKGGSMQ----TVSSQFR 654

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            ::|.:|:.::...||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..
Zfish   655 ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 719

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||:.|..|.:..| .:.:..:|..:.:....|...:|:.|.|:||.:..|...||..|.|:|
Zfish   720 FKQRYKVLNASVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKL 783

  Fly   844 RRAAVSVQRHVRGMLVRRQ---LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALTA 896
            .......|...|..|:||:   :..|:.|...:|         ..|...:...:.:.|.|.|.|.
Zfish   784 ASLVTMTQALCRAYLMRREFVKMTERRDAIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETE 848

  Fly   897 QRLWRGRQARRRVQQLRSDH-RRRQEAREAAQRAREAREAKQAVLERS---QLSYLDIPAELAFI 957
            :.|          ..::.|. :.:::..:|..:.:|..|...|:|:..   ||:.......|:..
Zfish   849 KEL----------ATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDA 903

  Fly   958 YSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAP 1022
            ..:.:|         |:|          |.:||...|.:.:           .||:...| |.|.
Zfish   904 EERCEG---------LIK----------SKIQLEAKLKETT-----------ERLEDEEE-INAE 937

  Fly  1023 LLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQV 1087
            |..:                                             .|.|.||     |:: 
Zfish   938 LTAK---------------------------------------------KRKLEDE-----CSE- 951

  Fly  1088 HGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSG 1152
                                             |.:.:||                         
Zfish   952 ---------------------------------LKKDIDD------------------------- 958

  Fly  1153 AVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAALAVSSLGVAS 1215
                                       |.|||.....:..|.::...  .||.|| ...|:|..:
Zfish   959 ---------------------------LELTLAKVEKEKHATENKVKNLTEEMAA-QDESIGKLT 995

  Fly  1216 RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPP 1280
            :....:.:..||..|        ||.||:           |.:.:..| ::|.|...|       
Zfish   996 KEKKALQEAHQQTLD--------DLQAEE-----------DKVNTLTK-SKTKLEQQV------- 1033

  Fly  1281 PAPPTSSGKEDVPRERRSSREL---LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLL 1342
                     :|:.......::|   |.|:    :|..|             |..|...:|:.|| 
Zfish  1034 ---------DDLEGSLEQEKKLRMDLERA----KRKLE-------------GDLKLAQESIMDL- 1071

  Fly  1343 AGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGS 1407
                                      .||:..|.|:|..  ||    ::.||...:.....|.|:
Zfish  1072 --------------------------ENDKQQSEEKLKK--KD----FETSQLLSKIEDEQSLGA 1104

  Fly  1408 HSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDA 1472
            ...|..  .|...|...:.:..||...|    |.:|..|.:|            |...|:|:|:.
Zfish  1105 QLQKKI--KELQARIEELEEEIEAERAA----RAKVEKQRAD------------LSRELEEISER 1151

  Fly  1473 RSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAII----KGGGVA 1533
            ...|........|...:.|:|           ||  .|.::||:.|.:.:..|..    :...||
Zfish  1152 LEEAGGATAAQIEMNKKREAE-----------FQ--KLRRDLEESTLQHEATAAALRKKQADSVA 1203

  Fly  1534 SKPEERD-----------EESEIE-DLDDYINELFEPIPVAEGLDKL--TSKEHLAVSIRGGGST 1584
            ...|:.|           |:||.: ::||..:.:.........|:|:  |.::.|: .|:  ...
Zfish  1204 ELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLS-EIK--SKN 1265

  Fly  1585 DSNGADPLLHQLMQLPG-----ETESG---------PALYQQ--QVQRAFLQSAMAQNLQIQQQL 1633
            |.|     |.||..|..     :||:|         .||..|  :.::||.|.......||::::
Zfish  1266 DEN-----LRQLNDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEV 1325

  Fly  1634 LAQN---QALQT------LL------SQQAAA------AAANNST----SPPPAPPILSSLSISP 1673
            .|:|   .|:|:      ||      .|:|.|      :.||:..    :......|..:..:..
Zfish  1326 KAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE 1390

  Fly  1674 PPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWR- 1737
            ...:...|::.....:..:.|                :|....:|:..|.  |..:.:.|...| 
Zfish  1391 SKKKLAQRLQEAEEQIEAVNS----------------KCASLEKTKQRLQ--GEVEDLMIDVERA 1437

  Fly  1738 --------------------WPPPQDEPQFQTEE--------DFFAFKMRQHQRKTTPQAQHHQM 1774
                                |....:|.|.:.|.        ....|||:....:|..|.:..:.
Zfish  1438 NALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKR 1502

  Fly  1775 TSNGGMMESGP-----GARG-------ASATAIEWEEFEIESP------TPPPMSGQLMRSSIRL 1821
            .:.....|...     |..|       .|..|:|.|:.||::.      |......:::|..:.|
Zfish  1503 ENKNLQQEISDLTEQIGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL 1567

  Fly  1822 ETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKL--- 1878
            ....:.....:..:|.:     |.:|.:...|||.:.:::..::..:...:...|.:.::::   
Zfish  1568 NQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLS 1632

  Fly  1879 -----SSEMRQRLEQVTAG------HSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVS- 1931
                 ::|.:::|..|.|.      | :...|..:.:.:....:.:.|..::|.::..|.|::. 
Zfish  1633 HANRQAAEAQKQLRNVQAQLKDAQLH-LDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQ 1696

  Fly  1932 ---GGNSGPGGVVDSHATV------RTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPI 1987
               |.......:||:...|      .|.:...:.||...           |:.....|       
Zfish  1697 TERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEAD-----------LVQIQSEV------- 1743

  Fly  1988 RPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTF------------ 2040
                         ..:...||:.|.:.....:.:.::.|.:     ::|:||.            
Zfish  1744 -------------EDTVQEARNAEDKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNLEV 1790

  Fly  2041 ------------------GAVRQQQMISSHHLHLED-------HSASSSPAVAAWEQAERERSRS 2080
                              |..:|.|.:.|....||.       ..|.:...|..:|:..:|.:..
Zfish  1791 TVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQ 1855

  Fly  2081 RSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERE 2134
            ....:...:..:.:.|:.:::..|....||   |..|:....|.::|:|:.|.|
Zfish  1856 TEEDKKNVNRLQDLVDKLQLKVKAYKRQSE---EAEEQANSHLSKLRKVQHELE 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 248/706 (35%)
MYSc_Myo15 169..828 CDD:276838 242/686 (35%)
MyTH4 1014..1171 CDD:295320 12/156 (8%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myhz1.2XP_005171981.1 Myosin_N 35..74 CDD:308391
MYSc_class_II 101..768 CDD:276951 242/686 (35%)
SMC_N 848..1925 CDD:330553 227/1420 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.000

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