DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo15b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_017214038.2 Gene:myo15b / 795537 ZFINID:ZDB-GENE-030131-4797 Length:1899 Species:Danio rerio


Alignment Length:2553 Identity:589/2553 - (23%)
Similarity:949/2553 - (37%) Gaps:756/2553 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   646 VDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAA 710
            |..||:||.|..|.:||||.|.|||.:|..|.::::.:....|.|     ||....:.:..||||
Zfish     9 VHNFLNKNHDQFRPEVLELFARSRLQMVSGLFRKVQERYIQQKEL-----GRARGHRNQMSTVAA 68

  Fly   711 RFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLR 775
            .|..||.:|...:.||...||||.|||..|.....|:..:..|||:.|:|:||.||:.|:|:|:.
Zfish    69 NFQQSLTELTTRLERCKTTFVRCFKPNYVKLPGIFDVDYITTQLRHGGILETIHIRKEGFPIRIP 133

  Fly   776 FQHFVERYRHLLPS-PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGR 839
            |..|:|||..||.. |:.:.  ..|....|:|.:   |.|...||||.|:|||:|.|::.:|...
Zfish   134 FAQFMERYGVLLSQRPINQS--LEEQVVTLIETI---GAEDGQYQLGLTKVFLKETLYQQVEEKW 193

  Fly   840 TERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQ 904
            :.....|||::||::||.:.||.....:..|..:|:..||.:|::.:::|::   ...:.|....
Zfish   194 SSTQTWAAVTIQRNIRGFICRRNFQFFKKKAIVIQSHIRGHQARKYFKQLKQ---CFTQFWATMM 255

  Fly   905 ARRRVQQLR--SDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPP 967
            ..|...:.|  .:|..|...:|.|:....:.|....:||        |||||:.......|.|..
Zfish   256 ITRNTIKRRHWKEHTDRSRVKEVAKPTSSSSEMDVGILE--------IPAELSARLRSSSGRSQG 312

  Fly   968 HGDRHLVKVLGTVPGPPSSA---VQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAAS 1029
            .|       :..|..|...|   :.||.|:.:..|.::::........|.:..|:..||    .|
Zfish   313 SG-------VSEVAPPQVKADHKLSLPLDIDRHPFSQYANTVLKDGWCQAQGYPLQRPL----TS 366

  Fly  1030 RD-QDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPN 1093
            .| :|.:.||.::|||||::.|..|.|.:|::|.:|||.|:....|:|||||.||   |:.....
Zfish   367 LDHEDARTALEIYKLILRFTGDSDLNGWQEQMLGNYIVEKSQIRPGIRDEILAQL---VYLTWDG 428

  Fly  1094 SGEATRL--WQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGA 1156
            ..:.|.|  |.||..||..|.||....|.|:::|.|..|...|.|...:||       :|..:.:
Zfish   429 DRQETNLRGWLLLACCLSAFTPSPDLEKPLLKYVSDRGPGEYRSLCQHKLL-------TSLPLPS 486

  Fly  1157 GACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV--ASRGW- 1218
            .|||...|..|||.|..|...|.|.:...:|....|.|:|||:.||.|:..:|..|:  |::|| 
Zfish   487 PACRRHPPTQLEWTANQRKGKMVLEVNTFNEEKLAVEVESWTTGEELASWILSYRGLTNATQGWS 551

  Fly  1219 -TLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPA 1282
             :|:.|:|  .||..|.|:||||:|..|         ||                     ||...
Zfish   552 VSLLADEG--WTDLTGCDFVMDLLAGVE---------SD---------------------VPMGH 584

  Fly  1283 PPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIV 1347
            |||.                       |:..|              .....|.::.|  :...|.
Zfish   585 PPTE-----------------------NDYLF--------------SDTSDRMETTD--IDAFIP 610

  Fly  1348 PVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKY 1412
            |.|:   .|.|    ||                       |.::              .||.:.|
Zfish   611 PAPS---MQAP----GL-----------------------PSFE--------------ASHWNTY 631

  Fly  1413 ADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAA 1477
            ...:.|.                        .||...:|.::||:|.||.|....:......|..
Zfish   632 EPLSTYQ------------------------GSQGRQMDSYVDDIFDPVFDHGPPDFDRMAMLNR 672

  Fly  1478 SIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEE 1542
            .:|||.                                     ..:.::..|.|:...|      
Zfish   673 RMRGGG-------------------------------------GMMPSMYTGAGMPMNP------ 694

  Fly  1543 SEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTD-----SNGADPLLHQL--MQLP 1600
                                              ::.|.|:|.     .....|::..:  |.:|
Zfish   695 ----------------------------------AMAGYGATPMMPNMMPATMPMMQPMPPMMMP 725

  Fly  1601 -GETESGPALYQQQV--QRAFL-QSA--MAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSP 1659
             ...::.||:..||:  |:||: |.|  :||.:.:|...|:|.|....:..:::...:.......
Zfish   726 TAMPQAMPAVNPQQMDQQQAFINQQALLLAQQMTMQAMSLSQKQQQDEMRRRESQRQSPRQRRRS 790

  Fly  1660 PP---APPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHF 1721
            ||   :|    |.|.||.|...|...:....:     ..|.|.|.|.|..|.|:..:|       
Zfish   791 PPRARSP----SRSPSPKPRSRPQSQRTNHQT-----PKQAPEPLPKPRSPEPVTERD------- 839

  Fly  1722 LDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPG 1786
                     ||       .|:|...|:.:.|||                                
Zfish   840 ---------VR-------APEDHGSFKEKRDFF-------------------------------- 856

  Fly  1787 ARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSV 1851
                                                                   |.:|      
Zfish   857 -------------------------------------------------------QKIG------ 860

  Fly  1852 VTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRK 1916
                                                                       ..||| 
Zfish   861 -----------------------------------------------------------TSDTR- 865

  Fly  1917 LMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVP 1981
                                                       |.|||.... |.:...|..|.|
Zfish   866 -------------------------------------------PKPAPKVAK-PLIYANPPVSQP 886

  Fly  1982 APPPPIRPPSMAPPAPPPAPQS---PPTARSPEPEPDYRTSS-SQVVKEHVPAFIQRQERDTFGA 2042
            ..|||::......|.||...:|   .|...||:|||   ||: .:::|::       |.|     
Zfish   887 KSPPPVKTQVKPLPEPPQIQKSGRESPEPTSPKPEP---TSNIREIIKQY-------QNR----- 936

  Fly  2043 VRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGS 2107
                                .:|...|:|.. |..::...:..|.:|.:.::   .:.:||.|  
Zfish   937 --------------------PNPEPKAYEPV-RVPAKQFLKKNDPKDEALAI---LKSQGPVS-- 975

  Fly  2108 GSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTH 2172
                 .:|::          .||:        .|:||:.:::.              |..:....
Zfish   976 -----HQKKQ----------WVEK--------PPSPPQQLESR--------------GPRSISNS 1003

  Fly  2173 MAQKY----EHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVP-PPSSTSPGLGVVSGVLMGS 2232
            |.||.    :....::|......||.:.|     |||     |:| ||...:|.|..::  :|..
Zfish  1004 MKQKQLSLADLFGSQRSQPLPRARESIPS-----PPP-----PIPDPPRQPAPALNQLN--MMAE 1056

  Fly  2233 GSG--------GSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRI 2289
            ...        .::...:|..:|.||.:|||:|.|.|....|..|:||..|::.|.:. ..||||
Zfish  1057 EESVRSQLHKFSASVYFSYPIMPGKLFLRKELFYPREKFNHPYTLNLLCEQIMRDTYS-DSCLRI 1120

  Fly  2290 TPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRAL---VKRHLVDMARD-WPLYFARL 2350
            :.:|:....::|....:                  |..:|:|   :|:.:|..||| |..|||||
Zfish  1121 SREERRKMKDLLASFHI------------------GTNIRSLDDAMKKRIVMAARDNWSNYFARL 1167

  Fly  2351 FAVQ---GAPLYPDVSIMGVSHSGLYL---ARR---DADYLIVVQAISFGEIQSAVTLPRPAALQ 2406
            |.|:   |.    |..::||||.|:.|   ||.   :..:|.|:...|:.::.| |.......:.
Zfish  1168 FNVKVGNGG----DAQMLGVSHRGIRLLKVARASGINPKHLKVLHTFSYSQVLS-VQQKGTGKVV 1227

  Fly  2407 LNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHA 2471
            :.|.| :.|.||:.:|..|.:::..|:.|..|:......:.|..     |.:..|.......|..
Zfish  1228 ITLSN-EELELHSQQAPQIAAVIRLFLMELIKNSEYVIAVKSYV-----TDDKSLLSFHRGDAIK 1286

  Fly  2472 QRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQ 2536
            ..|..|:..|........:|.| ..:...|.......|.....:|.:.:.:|             
Zfish  1287 LLNMDGLKDGWMFGSSGGRSGL-FPVDVTQPCAPPDYHSSNMDRQLERKKSM------------- 1337

  Fly  2537 QQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDA 2601
                  :.....|.:.....::: ..:|..:..:| |||.:::        ...::|:.      
Zfish  1338 ------RVTSSSRIVPSNGSINN-MPANVAEINTS-TNGSIYN--------MSVARSVA------ 1380

  Fly  2602 NYLQDESNGGTPPSVTKYSLL-------QFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQ 2659
                    ||:..||...|:.       ||.|..|.:....:|......      ||..|:|::.
Zfish  1381 --------GGSEYSVEVASIQRSEPEREQFIMTEFASKFFTEAINRGNM------RSLNEMVEYT 1431

  Fly  2660 GHAIRLPLLRL-PNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYC 2723
            .:.|:..|:.. .::|..|..:.|..::::..|.|:..:.||..||..:|....:...||||:||
Zfish  1432 PNPIQESLILFSDSELTRLGAQSFMVVMQFMLDQPMKKNQTEGDCVNFILQLGKEKEFLRDELYC 1496

  Fly  2724 QLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLT 2788
            |::||||.:|  ..::..|.|||.:::..:|.||:.|.||...||.:...|........|.:|..
Zfish  1497 QVIKQTTKHR--IKENCTRGWRLFNLVTGFFPCSNTLLPYCTRHLDTIIQDANHPYQELANICAK 1559

  Fly  2789 NLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTVVADVIAELCALLGV 2853
            ||:::...|||:::||..|:.|:.|||::||....||||.|.....|..:|..:|:.:.|..:|:
Zfish  1560 NLQRSLIFGGRRHIPSHSEMEAILAGRNSRRLPIMLPGGTEFACKIRSFSVAFEVVQDFCTEMGI 1624

  Fly  2854 ESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPM- 2917
            .:.||.:|||::...:|...|.|:.:|||:.|.   ||..|. ..|.|.|.:|     ::|... 
Zfish  1625 MNPAEMKEFSIHAAKKGGDVTRPIHSDEYLFDF---LLDDGS-IALSFKRLIW-----KQPLQFS 1680

  Fly  2918 -PLYVEVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLP 2981
             .||:|..:..:...||||.:. |..|...|.:.|   |.:.||.|.|..|:::|:..|||...|
Zfish  1681 NDLYLEFHYQLLVASYLEGKMF-LSMNSSTVYQQV---AELTALQHLALGLNNLPSNAEIKQYHP 1741

  Fly  2982 K-PALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPH 3045
            : ..|...:.|   .:..:::.:..:..:||...||:|:..:::.||||...|..:::.....| 
Zfish  1742 RMDGLNSTDER---LLATIRAQFSTLGPISPLDAKARFIKSISSLPLFGFDIFTAQKVSHRSCP- 1802

  Fly  3046 VEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVR-SEDGALFLDMKVGNLMQ 3109
                 ||.    ::|:|...:..|||.|.......|..:|:|.|.:| .:|....:::..|...|
Zfish  1803 -----SPS----LVAVNHEVITVLDPKTLNACLTMSMEDVLSLRSIRPKKDKLPSVEISFGGQTQ 1858

  Fly  3110 QRVIRVQTEQAHEISRLV 3127
            .:.:....:||.|:...:
Zfish  1859 HKTLSFNLKQAKELCHTI 1876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 75/190 (39%)
MYSc_Myo15 169..828 CDD:276838 72/182 (40%)
MyTH4 1014..1171 CDD:295320 58/159 (36%)
MyTH4 2704..2810 CDD:279165 37/105 (35%)
B41 2823..3033 CDD:214604 63/212 (30%)
FERM_B-lobe 2920..3025 CDD:271216 28/105 (27%)
FERM_C_MyoXV 3029..3138 CDD:270022 22/100 (22%)
myo15bXP_017214038.2 Motor_domain <5..182 CDD:328930 72/182 (40%)
IQ 221..241 CDD:279006 5/19 (26%)
MyTH4 359..503 CDD:321946 59/157 (38%)
GGN <812..>962 CDD:330621 52/410 (13%)
SH3 1262..1316 CDD:327375 9/59 (15%)
MyTH4 1476..1581 CDD:307090 38/106 (36%)
FERM_B-lobe 1590..1791 CDD:324381 64/216 (30%)
FERM_C_MyoXV 1787..1887 CDD:270022 22/100 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 196 1.000 Domainoid score I3076
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.810

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