Protein Alignment Myo10A and Myh10

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_017453033.1
• Gene: Myh10 / 79433
• RGDID: 71000
• Length: 2007
• Species: Rattus norvegicus
• Alignment Length: 2230
• Identity: 526/2230 - (23%)
• Similarity: 873/2230 - (39%)
• Gaps: 529/2230 - (23%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|...:.:.|.|:...
  Rat    85 SKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLP-IYSENIIEMYRGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-------------- 267
            .:|||::||..:|:..:   ...|.::.:||||:||||:||.|:||||.|.
  Rat   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   268 -PGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEK 330
             |........:..|:|:|.|:||:||||:|.:|||||||||::.:.|. :|.||||.|..|||||
  Rat   214 SPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   331 SRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GA 392
            ||.|.||..||.:|:||:||.|..|..:|...|...:.|.:|:.|... ..|:.|.::.|   .|
  Rat   279 SRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEA 342

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
            |.::|.|..|...:::|:::||..||:.|.:.:   ..:...:..:...:...|||.::.....|
  Rat   343 MHIMGFSHEEILSMLKVVSSVLQFGNISFKKER---NTDQASMPENTVAQKLCHLLGMNVMEFTR 404

  Fly   458 A-LTSRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRIS 519
            | ||.|....|  .::..|.   :||..|.:|.|||.|..||.|||.|||..:.:.....|..|.
  Rat   405 AILTPRIKVGRDYVQKAQTK---EQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIG 466

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHL 583
            ||||.|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|
  Rat   467 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDL 531

  Fly   584 LAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWY 644
            :.:  .|.|:..|||:|..||:|||.:|:||..........:.:||  ....:|.:.||||:|.|
  Rat   532 IERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDY 596

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGELTK------QLRAQRDAGKTLPKGSNGRFV---- 699
            ..|.:|.||.|.|..:|..||..|....|.||.|      |..:..|:...|.:....|.|
  Rat   597 KADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQ 661

  Fly   700 --------------TMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCV 750
                          |.|....||...:.:||.:|:.::...:|.|||||.||.||.|.::|...|
  Rat   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   751 LQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVE 814
            |.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..::.|:.   ::
  Rat   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALE---LD 788

  Fly   815 GPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRG 879
            ...|::|.:::|.|..:...||..|..::....:..|...||.|.|:..|::|...:.|:..
  Rat   789 PNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVL--- 850

  Fly   880 QRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAR---EAAQRAREAREAKQAVLE 941
            ||....|.:||.        |:..:...:|:.|....|:.:|.:   |...:.:|.:...:..||
  Rat   851 QRNCAAYLKLRH--------WQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELE 907

  Fly   942 RSQLSYLDIPAELAFIYSKLQGWSPPHGD------------RHLVKVLGTVPGPPSSAVQLPEDL 994
            ..:..:..:..|...:..:||..:....:            :.|.::|..:    .|.|:..|:.
  Rat   908 EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDL----ESRVEEEEER 968

  Fly   995 GQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEK 1059
            .|.              ||..::.:.|.:        ||.::.|           |:. |||::|
  Rat   969 NQI--------------LQNEKKKMQAHI--------QDLEEQL-----------DEE-EGARQK 999

  Fly  1060 LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNS---GEATRLWQLLGQCLCCFQPSAAFSKYL 1121
            |..:.:..:| ..:.:.:|:|: |.:|      ||   .|...:...:.:|..........:|.|
  Rat  1000 LQLEKVTAEA-KIKKMEEEVLL-LEDQ------NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1056

  Fly  1122 MR-------FVDDEAPESLRPLLLRQLL----RQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRG 1175
            .:       .:.|......:....||.|    |:..|.|:.
  Rat  1057 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD------------------------ 1097

  Fly  1176 CDMALPLTLPDEASQTVA-VD----SWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLD 1235
                    |.|:.::..| ||    ..|..||...      |..:||      |.:.|..:..|.
  Rat  1098 --------LQDQIAELQAQVDELKVQLTKKEEELQ------GALARG------DDETLHKNNALK 1142

  Fly  1236 YVMDLIAE-KELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSS 1299
            ...:|.|: .||...|.:.::.  |:.|:..:..|                   .|::...:...
  Rat  1143 VARELQAQIAELQEDFESEKAS--RNKAEKQKRDL-------------------SEELEALKTEL 1186

  Fly  1300 RELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGL 1364
            .:.|..::|..|...:||......:.:...:.|:....:.|:               ...|...|
  Rat  1187 EDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDM---------------RQRHATAL 1236

  Fly  1365 SESRLNDRYHSAERLA------PVGKDTGPR------------YQKSQHAGRRSHAASHGSHSS- 1410
            .|  |:::...|:|..      ..|.:|..:            ..:|:|..::..|.....|:.
  Rat  1237 EE--LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1299

  Fly  1411 --------KYADKAEYATRS----SAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLD 1463
                    :.|:||......    |.:.:.:|...:........:.||..|..:.|.
  Rat  1300 SEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQ-------- 1356

  Fly  1464 GSLDELSDARSLAASIR-----GGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEK--LTSKD 1521
               :|.....:|::.||     ..|.:::.|.|.|..                :||||  |..:.
  Rat  1357 ---EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----------------KNLEKQVLALQS 1402

  Fly  1522 QLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDS 1586
            |||        .:|.:..|:...||.|::...:|.:.:   |.|.:...::.||..
  Rat  1403 QLA--------DTKKKVDDDLGTIEGLEEAKKKLLKDV---EALSQRLEEKVLAYD--------- 1447

  Fly  1587 NGADPLLHQLMQLPGETESGPALYQQQVQRAFL----QSAMAQNLQIQQ----QLLAQNQALQTL 1643
                           :.|......||::....:    |..:..||:.:|    ||||:.:.:...
  Rat  1448 ---------------KLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISAR 1497

  Fly  1644 LSQQ---AAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPP 1705
            .:::   |.|.|....|         .:||::          :|...:|...|..:.........
  Rat  1498 YAEERDRAEAEAREKET---------KALSLA----------RALEEALEAKEEFERQNKQLRAD 1543

  Fly  1706 MPPPLECKDP-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQA 1769
            |...:..||. .:..|.|:...||...::.:.|....:.|.:.|..||   .|:|........:|
  Rat  1544 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED---AKLRLEVNMQAMKA 1605

  Fly  1770 QHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNN 1834
            |                             ||.:..|....:.:..|..::            ..
  Rat  1606 Q-----------------------------FERDLQTRDEQNEEKKRLLLK------------QV 1629

  Fly  1835 RDRDRETQDVGQPMQSVVTTKLAKKSFEI----------GADRPPPGSVGKL-KLSSEMR---QR 1885
            |:.:.|.:|..:.....|.   :||..||          .|::.....:.:| ||.::|:   :.
  Rat  1630 RELEAELEDERKQRALAVA---SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1691

  Fly  1886 LEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGG--------------LFASVSGGNSG 1936
            ||:..|........|.:||::  .|..:...|.||::|..              |...::...||
  Rat  1692 LEEARASRDEIFAQSKESEKK--LKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASG 1754

  Fly  1937 PGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP------- 1994
            ...::|....:..:|.::|.:|....:               ::.......|..::..
  Rat  1755 KSALLDEKRRLEARIAQLEEELEEEQS---------------NMELLNDRFRKTTLQVDTLNTEL 1804

  Fly  1995 PAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHL----- 2054
            .|...|.|....||            .|:.:::.....:.||.:  |||:.:...:...|
  Rat  1805 AAERSAAQKSDNAR------------QQLERQNKELKAKLQELE--GAVKSKFKATISALEAKIG 1855

  Fly  2055 HLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERE 2119
            .||:.          .||..:||:.:....|..|...:.::.:.|.|    ...:::.:|:.|:.
  Rat  1856 QLEEQ----------LEQEAKERAAANKLVRRTEKKLKEIFMQVEDE----RRHADQYKEQMEKA 1906

  Fly  2120 RERLYEIRQVERERESHKVYQPAPPRVIQASMD----TTGGHRRED-------RTGGLATFRTHM 2173
            ..|:.::::...|.|.......|..|.:|..:|    ...|..||.       |.||..:|
  Rat  1907 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISF---- 1967

  Fly  2174 AQKYEHERKRKSSASSGMRE 2193
                       ||:.||.|:
  Rat  1968 -----------SSSRSGRRQ 1976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	261/713 (37%)
		PTZ00121	<828..>943	CDD:173412	26/117 (22%)
		MyTH4	1014..1171	CDD:470587	28/170 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/72 (22%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh10	XP_017453033.1	Myosin_N	31..76	CDD:460670
		MYSc_Myh10	99..802	CDD:276952	261/713 (37%)
		Myosin_tail_1	879..1959	CDD:460256	228/1380 (17%)