Protein Alignment Myo10A and Myh10

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006534552.1
• Gene: Myh10 / 77579
• MGIID: 1930780
• Length: 2007
• Species: Mus musculus
• Alignment Length: 2236
• Identity: 524/2236 - (23%)
• Similarity: 872/2236 - (38%)
• Gaps: 541/2236 - (24%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|...:.:.|.|:...
Mouse    85 SKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLP-IYSENIIEMYRGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-------------- 267
            .:|||::||..:|:..:   ...|.::.:||||:||||:||.|:||||.|.
Mouse   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   268 -PGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEK 330
             |........:..|:|:|.|:||:||||:|.:|||||||||::.:.|. :|.||||.|..|||||
Mouse   214 SPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   331 SRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GA 392
            ||.|.||..||.:|:||:||.|..|..:|...|...:.|.:|:.|... ..|:.|.::.|   .|
Mouse   279 SRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEA 342

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
            |.::|.|..|...:::|:::||..||:.|.:.:   ..:...:..:...:...|||.::.....|
Mouse   343 MHIMGFSHEEILSMLKVVSSVLQFGNISFKKER---NTDQASMPENTVAQKLCHLLGMNVMEFTR 404

  Fly   458 A-LTSRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRIS 519
            | ||.|....|  .::..|.   :||..|.:|.|||.|..||.|||.|||..:.:.....|..|.
Mouse   405 AILTPRIKVGRDYVQKAQTK---EQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIG 466

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHL 583
            ||||.|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|
Mouse   467 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDL 531

  Fly   584 LAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWY 644
            :.:  .|.|:..|||:|..||:|||.:|:||..........:.:||  ....:|.:.||||:|.|
Mouse   532 IERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDY 596

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGS--------------- 694
            ..|.:|.||.|.|..:|..||..|....|.||.|      |..:|:.:.|
Mouse   597 KADEWLMKNMDPLNDNVATLLHQSSDRFVAELWK------DEIQTIQRASFYDSVSGLHEPPVDR 655

  Fly   695 ---------------NGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALR 744
                           ...:.|.|....||...:.:||.:|:.::...:|.|||||.||.||.|.:
Mouse   656 IVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGK 720

  Fly   745 MDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAM 808
            :|...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..::.|:
Mouse   721 LDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRAL 785

  Fly   809 PRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRL 873
            .   ::...|::|.:::|.|..:...||..|..::....:..|...||.|.|:..|::|...:.|
Mouse   786 E---LDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSAL 847

  Fly   874 QARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAR---EAAQRAREAREA 935
            :..   ||....|.:||.        |:..:...:|:.|....|:.:|.:   |...:.:|.:..
Mouse   848 KVL---QRNCAAYLKLRH--------WQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTK 901

  Fly   936 KQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGD------------RHLVKVLGTVPGPPSSAV 988
            .:..||..:..:..:..|...:..:||..:....:            :.|.::|..:    .|.|
Mouse   902 VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDL----ESRV 962

  Fly   989 QLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL 1053
            :..|:..|.              ||..::.:.|.:        ||.::.|           |:.
Mouse   963 EEEEERNQI--------------LQNEKKKMQAHI--------QDLEEQL-----------DEE- 993

  Fly  1054 EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNS---GEATRLWQLLGQCLCCFQPSA 1115
            |||::||..:.:..:| ..:.:.:|:|: |.:|      ||   .|...:...:.:|........
Mouse   994 EGARQKLQLEKVTAEA-KIKKMEEEVLL-LEDQ------NSKFIKEKKLMEDRIAECSSQLAEEE 1050

  Fly  1116 AFSKYLMR-------FVDDEAPESLRPLLLRQLL----RQQGGGTSSGAVGAGACRSFVPAWLEW 1169
            ..:|.|.:       .:.|......:....||.|    |:..|.|:.
Mouse  1051 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD------------------ 1097

  Fly  1170 RAWTRGCDMALPLTLPDEASQTVA-VD----SWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLT 1229
                          |.|:.::..| ||    ..|..||...      |..:||      |.:.|.
Mouse  1098 --------------LQDQIAELQAQVDELKVQLTKKEEELQ------GALARG------DDETLH 1136

  Fly  1230 DSCGLDYVMDLIAE-KELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVP 1293
            .:..|....:|.|: .||...|.:.::.  |:.|:..:..|                   .|::.
Mouse  1137 KNNALKVARELQAQIAELQEDFESEKAS--RNKAEKQKRDL-------------------SEELE 1180

  Fly  1294 RERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEP 1358
            ..:....:.|..::|..|...:||......:.:...:.|:....:.|:               ..
Mouse  1181 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDM---------------RQ 1230

  Fly  1359 LHTLGLSESRLNDRYHSAERLA------PVGKDTGPR------------YQKSQHAGRRSHAASH 1405
            .|...|.|  |:::...|:|..      ..|.:|..:            ..:|:|..::..|...
Mouse  1231 RHATALEE--LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1293

  Fly  1406 GSHSS---------KYADKAEYATRS----SAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDL 1457
            ..|:.         :.|:||......    |.:.:.:|...:........:.||..|..:.|.
Mouse  1294 ELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGIKFAKDAAGLESQLQDTQELLQ-- 1356

  Fly  1458 FSPVLDGSLDELSDARSLAASIR-----GGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEK- 1516
                     :|.....:|::.||     ..|.:::.|.|.|..                :||||
Mouse  1357 ---------EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----------------KNLEKQ 1396

  Fly  1517 -LTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRG 1580
             |..:.|||        .:|.:..|:...||.|::...:|.:.:   |.|.:...::.||..
Mouse  1397 VLALQSQLA--------DTKKKVDDDLGTIESLEEAKKKLLKDV---EALSQRLEEKVLAYD--- 1447

  Fly  1581 GGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFL----QSAMAQNLQIQQ----QLLAQN 1637
                                 :.|......||::....:    |..:..||:.:|    ||||:.
Mouse  1448 ---------------------KLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEE 1491

  Fly  1638 QALQTLLSQQ---AAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPP 1699
            :.:....:::   |.|.|....|         .:||::          :|...:|...|..:...
Mouse  1492 KGISARYAEERDRAEAEAREKET---------KALSLA----------RALEEALEAKEEFERQN 1537

  Fly  1700 PPPPPPMPPPLECKDP-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQR 1763
            ......|...:..||. .:..|.|:...||...::.:.|....:.|.:.|..||   .|:|....
Mouse  1538 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED---AKLRLEVN 1599

  Fly  1764 KTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTT 1828
            ....:||                             ||.:..|....:.:..|..::
Mouse  1600 MQAMKAQ-----------------------------FERDLQTRDEQNEEKKRLLLK-------- 1627

  Fly  1829 TSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEI----------GADRPPPGSVGKL-KLSSEM 1882
                ..|:.:.|.:|..:.....|.   :||..||          .|::.....:.:| ||.::|
Mouse  1628 ----QVRELEAELEDERKQRALAVA---SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM 1685

  Fly  1883 R---QRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGG--------------LFASV 1930
            :   :.||:..|........|.:||::  .|..:...|.||::|..              |...:
Mouse  1686 KDYQRELEEARASRDEIFAQSKESEKK--LKSLEAEILQLQEELASSERARRHAEQERDELADEI 1748

  Fly  1931 SGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP- 1994
            :...||...::|....:..:|.::|.:|....:               ::.......|..::..
Mouse  1749 ANSASGKSALLDEKRRLEARIAQLEEELEEEQS---------------NMELLNDRFRKTTLQVD 1798

  Fly  1995 ------PAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHH 2053
                  .|...|.|....||            .|:.:::.....:.||.:  |||:.:...:...
Mouse  1799 TLNTELAAERSAAQKSDNAR------------QQLERQNKELKAKLQELE--GAVKSKFKATISA 1849

  Fly  2054 L-----HLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKER 2113
            |     .||:.          .||..:||:.:....|..|...:.::.:.|.|    ...:::.:
Mouse  1850 LEAKIGQLEEQ----------LEQEAKERAAANKLVRRTEKKLKEIFMQVEDE----RRHADQYK 1900

  Fly  2114 EKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMD----TTGGHRRED-------RTGGLA 2167
            |:.|:...|:.::::...|.|.......|..|.:|..:|    ...|..||.       |.||..
Mouse  1901 EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1965

  Fly  2168 TFRTHMAQKYEHERKRKSSASSGMRE 2193
            :|               ||:.||.|:
Mouse  1966 SF---------------SSSRSGRRQ 1976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	259/719 (36%)
		PTZ00121	<828..>943	CDD:173412	26/117 (22%)
		MyTH4	1014..1171	CDD:470587	28/170 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/72 (22%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh10	XP_006534552.1	Myosin_N	31..76	CDD:460670
		MYSc_Myh10	99..802	CDD:276952	259/719 (36%)
		Myosin_tail_1	879..1959	CDD:460256	228/1380 (17%)