DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myh7l

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001070932.2 Gene:myh7l / 768300 ZFINID:ZDB-GENE-061027-393 Length:1936 Species:Danio rerio


Alignment Length:2032 Identity:490/2032 - (24%)
Similarity:833/2032 - (40%) Gaps:416/2032 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 SDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSI 191
            :||:.::|..|                 ..:|||.:|..|||.::|:||:.||...:|||::|..
Zfish    74 ADVLQQNPPKF-----------------DKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLF 121

  Fly   192 LIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKT 253
            .:.|||||..| .|..||...|.|:.....|||:::|...|:..:.:.   |.::|:||||:|||
Zfish   122 CVTVNPYKWLP-VYNQEVVIAYRGKERTEAPPHIYSISDNAYQYMLADRENQSILITGESGAGKT 185

  Fly   254 ESTKLVMQYLAAVVPGGGSA-----SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF 313
            .:||.|:||.|:|...||..     ...:.:||::|.|.|||||||:|.||||||||||::.::|
Zfish   186 VNTKRVIQYFASVAASGGKKDQDKNKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHF 250

  Fly   314 KS-GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQG 375
            .: |.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:.::.|.|  ::||
Zfish   251 DTRGKLASADIETYLLEKSRVTFQLKAERDYHIFYQILSN-KKPEILEMLLVTSNPYDYAFISQG 314

  Fly   376 ATDCASGRVD----WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVG 436
            .|...|  :|    ..:...|..:||.::.|:..:.::..|::|.||:.|.::|   .:|..|..
Zfish   315 ETTVPS--IDDSDELMATDSAFDILGFTQEEKNSVYKLTGAIMHYGNMKFKQKQ---REEQAEAD 374

  Fly   437 SDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVS 501
            ...:...:|:|:.:::..|.:.|.....:...|.:.....:.|...|..|.:||:|..:|.|:|.
Zfish   375 GTEDADKSAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVNYAIGALSKAVYEKMFLWMVV 439

  Fly   502 RINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARER 566
            |||..::...... :.|.:|||.|||....|:|||||||:.||.||.:||.|:|.|||.||.:|.
Zfish   440 RINQSLETKQPRQ-YFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG 503

  Fly   567 LEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI-- 628
            :||..:.:..:|.....|.:||:||..:|::|..||:|:|.:|..|.:.|| ..|..:.:||:  
Zfish   504 IEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDATFKAKLYDNHLGKSNNFQKPRLVK 568

  Fly   629 GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL----RAQRDAG 687
            |..|  |.:.||||.|.|.::.:|.||.|.|...|:.|...|.|.|:..|....    .|..|.|
Zfish   569 GKPEAHFALVHYAGTVDYNINNWLVKNEDPLNETVVGLYQKSSLKLLSNLFANYAGADSATGDGG 633

  Fly   688 KTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQ 752
            |...|.....|       .||:|...::|.:|:.::...||.||||:.||:.|....|:.|.|:.
Zfish   634 KKEKKKKGSSF-------QTVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMH 691

  Fly   753 QLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD 817
            |||..|:|:.|:|.::|:|.|:.:..|.:|||.|.|:.:..| .:.:..:...:.:....::...
Zfish   692 QLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPAAIPEG-QFIDSKKGAEKLLGSLDIDHQQ 755

  Fly   818 YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQAAATRLQARW- 877
            |:.|.|:||.:..|...||..|.|||.:....:|...||:|.|    :.:.||.|.   |..:| 
Zfish   756 YRFGHTKVFFKAGLLGQLEEMRDERLSKIITGIQAKSRGLLSRAEYIKMVERRDAL---LVIQWN 817

  Fly   878 -----------------------RGQRAQQRYERLRKGALTAQRLWRGRQARRR----------- 908
                                   |...|::....:::..|..:..:...:|||:           
Zfish   818 VRAFMAVKNWPWMKLFFKIKPLLRSAEAEKEMANMKEEFLKLKEAYAKSEARRKELEEKMVTLLQ 882

  Fly   909 --------VQQ---------------LRSDHRRRQEAREAAQRAREARE------AKQAVLERSQ 944
                    ||.               :::..:...:|:|..:|..:..|      ||:..|| .:
Zfish   883 EKNDLQLQVQAEQDNLCDAEERCEGLIKNKIQMEAKAKELTERLEDEEEMNAELTAKKRKLE-DE 946

  Fly   945 LSYL--DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAV---------------QLPE 992
            .|.|  ||. :|....:|::  ...|...:.||.|..........:               |..:
Zfish   947 CSELKKDID-DLELTLAKVE--KEKHATENKVKNLTEEMAALDDIIAKLTKEKKALQEAHQQTLD 1008

  Fly   993 DLGQFSFGKFSSVYCNGLRLQPRREPITAPL---------LTRAASRDQDFQDALAVFKLILRWS 1048
            || |....|.:::....::|:.:.:.:...|         |.||..:.:.  |.....:.|:...
Zfish  1009 DL-QSEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG--DLKLTQESIMDLE 1070

  Fly  1049 NDKALEGAKEKLLADYIVHKALSSRGLRDE--ILVQLCNQVHGLP------PNSGEATRLWQLLG 1105
            |||  :..:|||.........|:|: :.||  |::||..::..|.      ....||.|..:...
Zfish  1071 NDK--QQLEEKLKKKDFEISQLNSK-IDDEQSIIIQLQKKLKELQARVEELEEELEAERAARAKV 1132

  Fly  1106 QCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWR 1170
            :     :|.|..::.|     :|..|.|          ::.||.::..:.....|.     .|::
Zfish  1133 E-----KPRADLAREL-----EEISERL----------EEAGGATAAQIEMNKKRE-----AEFQ 1172

  Fly  1171 AWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLD 1235
            ...|..:.|   ||..||:.       .:..:..|.:|:.||..       :|:.|::...    
Zfish  1173 KLRRDLEEA---TLQHEATA-------ATLRKKQADSVAELGEQ-------IDNLQRVKQK---- 1216

  Fly  1236 YVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGK-----EDVPRE 1295
                  .|||        :|: ||.......:::...||        ..|:..|     ||...|
Zfish  1217 ------LEKE--------KSE-LRLELDDVASSMEHIVK--------SKTNMEKVNRTLEDQMNE 1258

  Fly  1296 RRSSRELLSRSSALNE----------------RYFEREPS----PGPGQGSSTGQAKSRSKSLDD 1340
            .|:..|...||  ||:                |..|.:.|    ...|:.|.:.|.:...:.||:
Zfish  1259 YRNKCEEYQRS--LNDFTTQKAKLQAENDEFSRQLEEKESLVSQLTRGKNSFSQQLEDLKRQLDE 1321

  Fly  1341 ------LLAGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAERL 1379
                  .||..:.....|.|        .||....|..|.|:.|            |.....|.|
Zfish  1322 EIKAKNALAHALQSARHDTDLLREQYEEEQEAKAELQRSMSKANTEVAQWRTKYETDAIQRTEEL 1386

  Fly  1380 APVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVP 1444
            ....|....|.|:::.|....:|.......:|:..:.|.   ...|.|...:.:.|:.:.:    
Zfish  1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNTAAASLDK---- 1444

  Fly  1445 SQASDVDQFLDDLFSPVLDGSLDEL----SDARSLAASI--RGGSYEQ----------ENE-AES 1492
             :....|:.:.: :....:.|..||    .:||||:..:  ...|||:          ||: .:.
Zfish  1445 -KQRHFDKIISE-WKQKYEESQCELESSQKEARSLSTELFKLKNSYEESMDHLETMKRENKILQE 1507

  Fly  1493 EIDDLDDYINDIFQPIPLVQNLEKLTSKDQL---AAIIKGGGVASKPEERDEESEIE------DL 1548
            ||.||.:.:.:..:.|..::.:.|...:::.   ||:.:..|.....|.:...:::|      |:
Zfish  1508 EISDLTEQLGEGGKTIHELEKVRKQLEQEKAEIQAALEEAEGSLEHEEGKILRTQLEFNQIKADI 1572

  Fly  1549 DDYINELFEPI------------PVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPG 1601
            :..::|..|.:            .:...|:..|...:.|:.|:.....|.|..:..|.|..:...
Zfish  1573 ERKLSEKDEEMEQVKRNQQRTIDTLQSALESETHSRNEALRIKKKMEGDLNEMEIQLSQANRQAA 1637

  Fly  1602 ETESGPALYQQQVQRAFLQ--------SAMAQNLQIQQQ----LLAQNQALQTLLSQ--QAAAAA 1652
            |.:......|..::.:.||        ..:.:|..|.::    |.|:.:.|:.:|.|  :....|
Zfish  1638 EAQKQLKSVQAHLKDSQLQLDDSLRSNDDLKENTAIVERRNALLQAELEELRAVLEQTERGRKLA 1702

  Fly  1653 ANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSE 1717
            ............:|.|.:.|....:..:....::....|.|::|              ||::..|
Zfish  1703 EQELLDVTERVQLLHSQNTSLINQKKKLETDLSQFQTEVEEAVQ--------------ECRNAEE 1753

  Fly  1718 TRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQMT 1775
                     :||     |..........:.:.|:|..|.  :|:::..:|....||     .|:.
Zfish  1754 ---------KAK-----KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804

  Fly  1776 SNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDR 1839
            ..||..:    .:...|...|.| |.|.|..........:.:...|::..|..|       :.||
Zfish  1805 MKGGKKQ----VQKLEARVRELECEVEAEQKRSSESVKGIRKYERRIKELTYQT-------EEDR 1858

  Fly  1840 ET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPGS---VGKL-KLSSEMRQRLEQVTAGHSVR 1896
            :.    ||:...:|      |..|:::..|:.....:   :||. ||..|:.:..|:.....|..
Zfish  1859 KNIARLQDLVDKLQ------LKVKAYKRAAEESEEQANVHLGKFRKLQHELDEAEERADIAESQV 1917

  Fly  1897 STVSTKSEQRAPAKLED 1913
            :.:..||....|.|..|
Zfish  1918 NKLRAKSRDVGPKKAFD 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 245/703 (35%)
MYSc_Myo15 169..828 CDD:276838 237/682 (35%)
MyTH4 1014..1171 CDD:295320 33/173 (19%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh7lNP_001070932.2 Myosin_N 35..72 CDD:280832
Myosin_head 87..766 CDD:278492 244/694 (35%)
MYSc_class_II 99..766 CDD:276951 237/682 (35%)
Myosin_tail_1 846..1923 CDD:279860 218/1211 (18%)
RILP-like 961..1094 CDD:304877 25/140 (18%)
MM_CoA_mutase <1132..1293 CDD:294532 42/231 (18%)
MIT_CorA-like <1295..>1407 CDD:294313 23/111 (21%)
COG6 1372..>1505 CDD:303003 26/141 (18%)
ATP-synt_B <1500..1608 CDD:304375 18/107 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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