DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and myo19

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001122117.1	Gene:	myo19 / 734140	XenbaseID:	XB-GENE-999897	Length:	969	Species:	Xenopus tropicalis

Alignment Length:	870	Identity:	283/870 - (32%)
Similarity:	433/870 - (49%)	Gaps:	146/870 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQY--AGRPLGS 220
            :|:|.::.:..|::|..|:.||..|:.||.||..::||||::.....|..||.|:|  |..|.|
Frog    46 DDLTKVNPVTTATVLKCLQARYSAGVFYTNAGCTVVAVNPFRPVCKLYSSEVMKEYHAASNPQG- 109

  Fly   221 LPPHLFAIGAAAHAAL-----PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV---- 276
            ..||:|.:...|:..:     |..|.:::|||||:|||.:::.:|::.|.|     |||..
Frog   110 CKPHIFTVAEQAYKNVQSQIQPVNQSIIVSGESGAGKTWTSRCLMKFYATV-----SASRCYITN 169

  Fly   277 -----ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVT 335
                 |..::|::.|::||||||.|.||.||||||||:::.. ::..|.||.|..|||||:|:..
Frog   170 EMVERIESRVLDSNPVMEAFGNACTLRNHNSSRFGKYIQLQLNRTQQITGASIQTYLLEKTRVAH 234

  Fly   336 QAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYL----NQGATDCASGRVDWESLQGAMQVL 396
            |||.|||:|:||:::.|.|..||.::.|.|...:.:|    |....|      |:|..:.||..|
Frog   235 QAPLERNFHIFYQVVKGASRHEREEWNLPEKANFSWLPNYENNLEED------DFEVTKDAMLHL 293

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHR--------RQLRHGQEGVEVGSDAEIKWAAHLLHISAD 453
            |:.:..:..|.::|:.:|||||:.|..        ..|.:.||...|        ||.||.|...
Frog   294 GIDQTTQNNIFKILSGLLHLGNIQFSDSVDESQPCEPLNYTQEFASV--------AASLLKIPVS 350

  Fly   454 GLHRALTSRT-TEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR 517
            .|...|:.|| |..:.:....|....:....||..||.:||.||.|||:.||..:    ..:|:|
Frog   351 HLLERLSIRTITAGKQQVFKKPCRKSECDTRRDCLAKTIYARLFEWLVTVINENI----CAEAYR 411

  Fly   518 ----ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNL 578
                |.:||::|||...||:.||||||||||.||.:|..|..|.:|.|||.|.|||:.:::.||.
Frog   412 WNNFIGLLDVYGFESFPENNLEQLCINYANEKLQQHFVSHYLKSQQDEYAAEGLEWSFISYQDNQ 476

  Fly   579 PVIHLLAKKPVGICHLLDDESNFPRATDL----SFLEKCHYNHALSELYARPRIGAQEFG----- 634
            ..:.|:...|:.|..||::|....|::|.    |.|||     |||.   ...||..:|.
Frog   477 SCVDLIEGSPISIFSLLNEECRLNRSSDAGQLQSRLEK-----ALSH---NKSIGRDKFSKKPNF 533

  Fly   635 -VTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRF 698
             |:||||:|.|.::...:||:|.:..::::||..|...|:     |:....:..|.:...:|.|.
Frog   534 IVSHYAGKVQYQIEDMAEKNKDPVPPELIQLLQESDDHLL-----QILFPVENNKPVYGATNNRA 593

  Fly   699 VTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTI 763
            |.:     ||.::|..||:.|:|.:....|.::||||||.:..||......||.||...|:::||
Frog   594 VGV-----TVVSKFKGSLESLMQILHSTTPHYIRCIKPNVDCQALVFRQEEVLMQLEACGIVETI 653

  Fly   764 QIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQL-------- 820
            .|...|:|:|:.|:.|||||..:.|..:.....:.: |..|.:   :.|.|..| ||
Frog   654 NISAAGFPIRISFESFVERYSVIAPRQIHMENNFND-CLFLKK---KQGFEKTD-QLPSKLQTIL 713

  Fly   821 --------------------GATRVFLREALHRALESGRTERLRRAAVSVQ---RHVRGMLVRRQ 862
                                |.|:|||...:...||..|.|.:...||.:|   |..|    :|:
Frog   714 HAVLSKLCKDSTLSNTLVHCGTTKVFLTHLMVELLEERRLEAICSKAVCIQCCWRRYR----QRK 774

  Fly   863 LARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQ 927
            ||::..|||.:||..:|...::..||:...|...:|:|:             ..:.:.||..||:
Frog   775 LAKQNRAATTIQAAVKGWLTKKYIERMHNAATVIKRIWK-------------KWKEKMEALAAAE 826

  Fly   928 RAREAREAKQAVLERSQLSYLDIPA 952
            ......:.::.:|       |.:||
Frog   827 LDDSIEDVERTLL-------LSVPA 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	252/749 (34%)
		MYSc_Myo15	169..828	CDD:276838	249/730 (34%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo19	NP_001122117.1	MYSc	45..752	CDD:214580	254/752 (34%)
myo19	NP_001122117.1	MYSc_Myo19	57..741	CDD:276846	249/730 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910