DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myh14

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001258467.1	Gene:	Myh14 / 71960	MGIID:	1919210	Length:	2033	Species:	Mus musculus

Alignment Length:	2325	Identity:	554/2325 - (23%)
Similarity:	888/2325 - (38%)	Gaps:	572/2325 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PQV---VKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSG--------------------V 157
            |||   .:|:..:.|::   |....|....||...|..:|..||                    .
Mouse    42 PQVEWTARRMVWVPSEL---HGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKA 103

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |||..|..|:|||:|.|||.||..|||||::|...:.:||||..| .|...:.:.|.|:....:|
Mouse   104 EDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLP-IYTEAIVEMYRGKKRHEVP 167

  Fly   223 PHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV--PGGGSASAV---ITE 279
            ||::|:...|:.::   ...|.::.:||||:||||:||.|:||||.|.  |.|.....|   :..
Mouse   168 PHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGELER 232

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..|.::
Mouse   233 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGANIETYLLEKSRAIRQAKDECSF 297

  Fly   344 HVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD--WESLQGAMQVLGVSEGEREGI 406
            |:||:||||..|..::...|.....|.:|..|.:.......:  .|:|: :::|||:...|...:
Mouse   298 HIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE-SLRVLGLLPEEITAM 361

  Fly   407 VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            :|.::|||..||:...:.  |:..:.....:.|..| ...||.:......|||.:...:...:.:
Mouse   362 LRTVSAVLQFGNIVLKKE--RNTDQATMPDNTAAQK-LCRLLGLGVTDFSRALLTPRIKVGRDYV 423

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ......:||..|.:|.|||.|..||.|||.|:|..:.:.....|..:.||||.|||....|||||
Mouse   424 QKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQ 488

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVGICHLLDDE 598
            |||||.||.||..||..:|.|||.||.||.:.||.|.:. |..|.|.|:.:  .|.|:..|||:|
Mouse   489 LCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEE 553

  Fly   599 SNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDV 661
            ..||:|||.||:||..........:.|||  ....:|.|.||||:|.|....:|.||.|.|..:|
Mouse   554 CWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPLNDNV 618

  Fly   662 LELLASSRLPLVGELTKQLR---------------AQRDAGK----------------------- 688
            ..||..|...|..|:.|..:               :...||:
Mouse   619 AALLHQSTDRLTAEIWKDEQGGLQQFTLLGSFPSPSPGPAGRLGSGASPPGVGSLCAPTVEGIVG 683

  Fly   689 -----TLPKGSNGRFVTMKPRT---PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRM 745
                 :|..|..|.    :||.   .||...:.:||.:|:.::...:|.|||||.||.||.|.::
Mouse   684 LEQVSSLGDGPPGG----RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKL 744

  Fly   746 DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMP 809
            :...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..:::|:.
Mouse   745 EPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALE 809

  Fly   810 RTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARR--QAAATR 872
               ::...|::|.:::|.|..:...||..|..::....||.|...||.|.||...||  |.:|.|
Mouse   810 ---LDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQRRQQQQSALR 871

  Fly   873 LQAR-------------WR--------------GQRAQQRYERLRK-GALTAQRLWRGRQARRRV 909
            :..|             ||              .:..|.|.:.|:| ..|..|......:.:.||
Mouse   872 VMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRV 936

  Fly   910 QQLRSDHRR-RQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHL 973
            .||..:..| .::.|..|:...||.|.:..:..|.|        ||..:.::|:
Mouse   937 AQLEEERTRLAEQLRAEAELCSEAEETRARLAARKQ--------ELELVVTELE----------- 982

  Fly   974 VKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDAL 1038
                        :.|...|:..:              :||..::        |.....|:.:..|
Mouse   983 ------------ARVGEEEECSR--------------QLQSEKK--------RLQQHIQELESHL 1013

  Fly  1039 AVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQL 1103
                        :|.|||::||..:.:..:|...:...|.:|         |...:.:.::..:|
Mouse  1014 ------------EAEEGARQKLQLEKVTTEAKMKKFEEDLLL---------LEDQNSKLSKERRL 1057

  Fly  1104 LGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLR----------QLLRQQGGGTSSGAVGAGA 1158
            |.:.|..|...||        .::|..:||..|.|:          :|.:::.|...
Mouse  1058 LEERLAEFSSQAA--------EEEEKVKSLNKLRLKYEATISDMEDRLKKEEKGRQE-------- 1106

  Fly  1159 CRSFVPAWLEWRAWTRGCDMALPLTLPDEAS--QTVAVDSWTSCEEAAALAVSSLGVASRGWTLV 1221
                    ||          .|...|..|:|  |...|:.....||..|    .||...
Mouse  1107 --------LE----------KLKRRLDGESSELQEQMVEQKQRAEELLA----QLGRKE------ 1143

  Fly  1222 LDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTS 1286
             |:.|...          |.||:|     ...|:.||:| .:.|:..|.:|
Mouse  1144 -DELQAAL----------LRAEEE-----GGARAQLLKS-LREAQAGLAEA-------------- 1177

  Fly  1287 SGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQ---GSSTGQAKSRSKSLDDLLAGDIVP 1348
              :||:..||.:..:...:...|.|   |.|...|..:   .|:..|.:.|||.     ..::..
Mouse  1178 --QEDLEAERVARAKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRSKR-----EQEVTE 1232

  Fly  1349 VPTDCDSQEPLHTLGLSESRLNDRYHS------AERLAPVGKDTGPRYQKSQHAGRRSHAASHGS 1407
            :....:.:...|.:.:.|.|   :.||      ||:|               ...||.......:
Mouse  1233 LKKALEEESRAHEVSMQELR---QRHSQALVEMAEQL---------------EQARRGKGVWEKT 1279

  Fly  1408 HSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQ-------ASDVDQFLDDLFSPV--LD 1463
            ..|..|:.:|.....|::..:.:    ....:|.|:.||       :||.::...:....:  ..
Mouse  1280 RLSLEAEVSELKAELSSLQTSRQ----EGEQKRRRLESQLQEVQGRSSDSERARSEAAEKLQRAQ 1340

  Fly  1464 GSLDELSDARSLAAS--IRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAI 1526
            ..|:.:|.|.|.|.|  ||.|  ::.:.|||::.|..:.:.:        :...||....::.|:
Mouse  1341 AELESVSTALSEAESKAIRLG--KELSSAESQLHDTQELLQE--------ETRAKLALGSRVRAL 1395

  Fly  1527 -IKGGGVASKPEE---------RDEESEIEDLDDYINELFEPIPVAEGLD---KLTSKEHLAVSI 1578
             .:..|:..:.||         |:.:|....|.::.....|...|.|..:   :..::|...::.
Mouse  1396 EAEAAGLREQMEEEVVARERAGRELQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQ 1460

  Fly  1579 RGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTL 1643
            |....|::  .:.|.....:|..|.:.......||.|   |.|.:.:..:...||||:.:|....
Mouse  1461 RLAEKTEA--VERLERARRRLQQELDDATVDLGQQKQ---LLSTLEKKQRKFDQLLAEEKAAVLR 1520

  Fly  1644 LSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRM-KATRSSLVVMESLQPPPPPPPPPMP 1707
            ..:......|........|..:..:|.......:...|. :|.|:.|..:.|.:
Mouse  1521 AVEDRERIEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK----------- 1574

  Fly  1708 PPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHH 1772
                 .|..:..|.|:...:|........|....:.|.:....||   .|:|........:|||.
Mouse  1575 -----DDVGKNVHELERARKAAEQAASDLRTQVTELEDELTAAED---AKLRLEVTVQALKAQHE 1631

  Fly  1773 QMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDR 1837
            :...  |..::|...|...|..:...|.|.:............|..:.||.           .:.
Mouse  1632 RDLQ--GRDDAGEERRRQLAKQLRDAEVERDEERKQRALAMAARKKLELEL-----------EEL 1683

  Fly  1838 DRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTK 1902
            ..:|...||..:..| .:|.|...::                .|:.:.:|:..:......|:|.:
Mouse  1684 KAQTSAAGQGKEEAV-KQLKKMQVQM----------------KELWREVEETRSSRDEMFTLSRE 1731

  Fly  1903 SEQRAPAKLEDTRKLMLQQQLGG--------------LFASVSGGNSGPGGVVDSHATVRTQIER 1953
            :|::  .|..:...|.||::|..              :...|:.||.       |.|....:..:
Mouse  1732 NEKK--LKGLEAEVLRLQEELAASDRARRQAQQDRDEMAEEVASGNL-------SKAATLEEKRQ 1787

  Fly  1954 MEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRT 2018
            :||:||                                                 ..|.|.:...
Mouse  1788 LEGRLS-------------------------------------------------QLEEELEEEQ 1803

  Fly  2019 SSSQVVKEHVPAFI---------------------------QRQ---------ERDTFGAVRQQQ 2047
            ::|:::|:|....:                           :||         |.|.....||:.
Mouse  1804 NNSELLKDHYRKLVLQVESLTTELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKM 1868

  Fly  2048 MISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKE 2112
            :|::    ||...|.:...:   ||..|||..|....|..|...:.|..:.:.|...    :::.
Mouse  1869 LIAA----LESKLAQAEEQL---EQESRERILSGKLVRRAEKRLKEVVLQVDEERRV----ADQV 1922

  Fly  2113 REKRERERERLYEI-RQVERERESHKVYQPAPPRVIQASMDTTGGH----------RREDRTGGL 2166
            |::.|:...||.:: ||:|...|.....|....|:.:...|.|...          |...|.|.|
Mouse  1923 RDQLEKSNLRLKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPL 1987

  Fly  2167 ATFRTH-----------MAQKYEHERKRKSSASSGMREELDSMHMTTPPP 2205
             ||.|.           :|...|.....:..::.|...|       .|||
Mouse  1988 -TFTTRTVRQVFRLEEGVASDEEEAEGAEPGSAPGQEPE-------APPP 2029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	265/762 (35%)
		MYSc_Myo15	169..828	CDD:276838	257/721 (36%)
		MyTH4	1014..1171	CDD:295320	28/166 (17%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh14	NP_001258467.1	Myosin_head	104..825	CDD:278492	263/732 (36%)
		MYSc_Myh14_mammals	115..825	CDD:276893	257/721 (36%)
		Myosin_tail_1	902..1982	CDD:279860	245/1393 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000