Protein Alignment Myo10A and Myo1e

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_011241116.1
• Gene: Myo1e / 71602
• MGIID: 106621
• Length: 1119
• Species: Mus musculus
• Alignment Length: 872
• Identity: 282/872 - (32%)
• Similarity: 445/872 - (51%)
• Gaps: 153/872 - (17%)

  Fly   134 PQTFALQPG-EGSLR---ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIA 194
            |.....:|| :|:.|   ...::..|||:||.||..:.|:|::.||:.||....|:|:.||:||:
Mouse     6 PLPLMTKPGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLIS 70

  Fly   195 VNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTEST 256
            |||:|..| .:|.:..:.|.|......|||::|:..:.:..:   ...|.|:||||||:|||.:.
Mouse    71 VNPFKQMP-YFGEKEVEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAA 134

  Fly   257 KLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIV-G 320
            |.:|.|::. |.|||.....:.:.||::.|||||||||:|.||:||||||||.|:.|..|... |
Mouse   135 KYIMSYVSR-VSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDG 198

  Fly   321 AKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGAT---DCASG 382
            .||:.:||||||:|.:.||||::|:||:|:.|.|..::...|:...|.|:||:...:   |....
Mouse   199 GKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDD 263

  Fly   383 RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK----- 442
            :.|::....||.|:|:...|:..:::::|.:|||||:.|.           |||:.|.::
Mouse   264 KRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNISFK-----------EVGNYAAVESEEFL 317

  Fly   443 -WAAHLLHISADGLHRALTSRTTEA----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSR 502
             :.|:||.|:.|.|...||||..::    ::|.:|..|.::||...|||.||||:|.:|::||..
Mouse   318 AFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDS 382

  Fly   503 INSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERL 567
            ||..::|  .|:.:.|.:|||:|||...:|.|||.|||:.||.||..|.:...|.||.||.:|.:
Mouse   383 INKAMEK--DHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGI 445

  Fly   568 EWTPLAWDDNLPVIHLLAKK--PVGICHLLDDESNFPRATDLSFLEKCHYNHALSE-------LY 623
            .|||:.:.:|..|..|:..|  |.||..:|||              .|...||:.|       ..
Mouse   446 RWTPIEYFNNKIVCDLIESKVNPPGIMSILDD--------------VCATMHAVGEGADQTLLQK 496

  Fly   624 ARPRIGAQE--------FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-TKQ 679
            .:.:||:.|        |.:.||||:|.|.:|||.::|||.|..|::||:.||.||.:..| .:.
Mouse   497 LQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPEN 561

  Fly   680 LRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALR 744
            |:|.:                 |.|..|..::.......|:.::.:|.|.::||||||:.|....
Mouse   562 LQADK-----------------KGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKD 609

  Fly   745 MDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEA 807
            .:...|..|:.|||:.:.|::|:.||..|..||.|::||..|..:  |:.||    :..:.:|..
Mouse   610 WEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRG----DEKQGVLHL 670

  Fly   808 MPRTGVEGPDYQLGATRVFLR--EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAA 870
            :....::...:|||.::||::  |:|. .||..|
Mouse   671 LQSVNMDSDQFQLGRSKVFIKAPESLF-LLEEMR------------------------------- 703

  Fly   871 TRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDH-----RRRQEAREAAQR-- 928
                     :|....|.|:      .|:.||...||::..|:|.:.     .:::..|.:..|
Mouse   704 ---------ERKYDGYARV------IQKTWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNF 753

  Fly   929 ------AREAREAKQAVLERSQLSYLD 949
                  ..|..|.:|.|.:|.::.:.|
Mouse   754 IGDYIGMEERPELQQFVGKREKIDFAD 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	246/695 (35%)
		PTZ00121	<828..>943	CDD:173412	21/129 (16%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1e	XP_011241116.1	MYSc_Myo1	45..691	CDD:276829	246/695 (35%)
		Myosin_TH1	731..932	CDD:461801	9/50 (18%)
		SH3_MyoIe_If_like	1067..1118	CDD:212761