DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh7b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_017174700.1 Gene:Myh7b / 668940 MGIID:3710243 Length:1947 Species:Mus musculus


Alignment Length:2151 Identity:546/2151 - (25%)
Similarity:870/2151 - (40%) Gaps:448/2151 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 RQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQY 213
            |.||    :|||.::..|:||::|.|||.||.:.:|||::|...:.:||||..| .|...|...|
Mouse    82 RFDL----LEDMAMMTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLP-VYTAAVVAAY 141

  Fly   214 AGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-----PG- 269
            .|:.....|||::|:...|:..:   ...|.::|:||||:|||.:||.|:||.|.|.     || 
Mouse   142 KGKRRSEAPPHIYAVADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGK 206

  Fly   270 ---------GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKIT 324
                     ||:    :.:||:||.|.:||||||:|.||||||||||::.::| .:|.:..|.|.
Mouse   207 KAQFLATKTGGT----LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADID 267

  Fly   325 QYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWE 387
            .|||||||::.|.||||.|||:|::|.| .:.|.....||..:.|.|  .:||.| ......|.|
Mouse   268 SYLLEKSRVIFQLPGERGYHVYYQILSG-KKPELQDMLLLSMNPYDYHFCSQGVT-TVDNMDDGE 330

  Fly   388 SL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLH 449
            .|   ..||.:||.|..|:....:::.|:||.||:.|.::|   .:|..|.........||:|:.
Mouse   331 ELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQ---REEQAEADGTESADKAAYLMG 392

  Fly   450 ISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD 514
            :|:..|.:.|.........|.:.....::|.:.|..|.|||.|..||.|||||||.      |.|
Mouse   393 VSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQ------TLD 451

  Fly   515 AHR-----ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAW 574
            ...     |.:|||.|||....|||||||||:.||.||.:||:|:|.|||.||.||.::|..:.:
Mouse   452 TKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDF 516

  Fly   575 D-DNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHA-LSELYARPRIGAQ-----E 632
            . |..|.|.|: :||:||..:|::|..||:|:|.||..|.:.||: .|..:.:||...:     .
Mouse   517 GLDLQPCIDLI-EKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAH 580

  Fly   633 FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG--KTLPKGSN 695
            |.|.||||.|.|.:.|:|:||:|.|...|:.:...|:..|:..|.:..     ||  .|.|..|.
Mouse   581 FEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENY-----AGSCSTEPPKSG 640

  Fly   696 GRFVTMKPRT-PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGM 759
            .:....|..: .||:....::|.:|:.::....|.|||||.||:.|....||...||.|||..|:
Mouse   641 VKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSFLVLHQLRCNGV 705

  Fly   760 LDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGT--PYRELCRALLEAMPRTGVEGPDYQLGA 822
            |:.|:|.::|:|.||.:..|.:|||.|.||.:...|  ..|:....||.::   .::...||.|.
Mouse   706 LEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSL---DIDHTQYQFGH 767

  Fly   823 TRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQAAATRLQARWRGQRAQ 883
            |:||.:..|...||..|.:||.:....:|...||.|:|    |.|..|.|..| :|...|...|.
Mouse   768 TKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFT-IQWNIRAFNAV 831

  Fly   884 QRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYL 948
            :.:..: |.....:.|.|..||...:..||::.|..:.|...|       |||:..||.:|:|..
Mouse   832 KNWSWM-KLFFKMKPLLRSAQAEEELAALRAELRGLRGALATA-------EAKRQELEETQVSVT 888

  Fly   949 DIPAELAFIYSKLQGWSPPHGDRH-----LVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN 1008
            ....:||.   :||.......|..     |:|          |.|||...:.:.|          
Mouse   889 QEKNDLAL---QLQAEQDNLADAEERCHLLIK----------SKVQLEAKVKELS---------- 930

  Fly  1009 GLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL---EGAKEKLLADYIVHKAL 1070
             .||:...| :.|.|    |:|.:..:|.....|..:   :|..|   :..|||...:..|....
Mouse   931 -ERLEDEEE-VNADL----AARRRKLEDECTELKKDI---DDLELTLAKAEKEKQATENKVKNLT 986

  Fly  1071 SSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRF---VDD----- 1127
            ......||.:|:|..:...|.    ||.:  |.||.........:|.:|..:|.   |:|     
Mouse   987 EEMAALDEAVVRLTKEKKALQ----EAHQ--QALGDLQAEEDRVSALAKAKIRLEQQVEDLECSL 1045

  Fly  1128 EAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMA-LPLTLPDEASQT 1191
            |..:.||....|...:.:|....:........:.  ...||.:...:..::: |.|.:.||  |.
Mouse  1046 EQEKKLRMDTERAKRKLEGDLKLTQETVTDTTQD--KQQLEEKLKKKDSELSQLNLRVEDE--QL 1106

  Fly  1192 VAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSD 1256
            |.|......:|..|.|                  ::|.:        :|.||:       |.|:.
Mouse  1107 VGVQLQKKIKELQARA------------------EELEE--------ELEAER-------AARAR 1138

  Fly  1257 LLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPG 1321
            :.:..|:.|| .|.:..:|   ...|...|:|:.:..|:|.:....|.|.  |.|.....|.:..
Mouse  1139 VEKQRAEAAR-ELEELSER---LEEAGGASAGQREGCRKREAELGRLRRE--LEEAVLRHEATVA 1197

  Fly  1322 PGQGSSTGQAKSRSKSLDDL------LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLA 1380
            ..:......|...|:.:|.|      |..:...:..:.|.      ||.|...|.....|||:|.
Mouse  1198 ALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDD------LGASVETLARGKASAEKLC 1256

  Fly  1381 PVGKD---------TGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLAS 1436
            ...:|         ...:.|.:..:.:|....:......:..::.|......:...||.|.||..
Mouse  1257 RTYEDQLSEAKIKVEELQRQLADASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEE 1321

  Fly  1437 HVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYI 1501
            ..|::...|:|.               |:|.....|......:....:|:|:||::|:..|....
Mouse  1322 LRRQLEEESKAK---------------GALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKA 1371

  Fly  1502 N-DIFQ-----PIPLVQNLEKL-TSKDQLAAII----KGGGVASKPEERDEESEIE---DLDDYI 1552
            | ::.|     ....:|..|:| .:|.:||..:    :|...|:......|::::.   :.:|..
Mouse  1372 NAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1436

  Fly  1553 NELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETES--------GPAL 1609
            .||......|..|||  .:.||           ....:....|..::..|.|:        |..|
Mouse  1437 LELERATSAAAALDK--KQRHL-----------ERALEERRRQEEEMQRELEAAQREARGLGTEL 1488

  Fly  1610 YQ-----QQVQRAFLQSAMAQNLQIQ-----------------QQLLAQNQALQTLLSQ-QAAAA 1651
            ::     ::...| |::...:|..:|                 |:|....:||:...|: |||..
Mouse  1489 FRLRHSHEEALEA-LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSELQAALE 1552

  Fly  1652 AANNSTSPPPAPPILSSLSISPPPPQSPMRM--------KATRSSLVVMESLQPPPPPPPPPMPP 1708
            .|..:........:...|.:|....:...::        ...|:....:||||            
Mouse  1553 EAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQ------------ 1605

  Fly  1709 PLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD-EPQF-----QTEEDFFAFKMRQHQRKTTP 1767
               ....:|||      .|.:.:|:.|.......| |.|.     |..|...|.::.|.|.|...
Mouse  1606 ---ASLDAETR------ARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQ 1661

  Fly  1768 QAQHHQMTSNGGMMESGPG-ARGASATAIEWEE----FEIESPTPPPMSGQLMRSSIRLETTTTT 1827
            ..:..:......:.|.|.. .|.|:..|.|.||    .|....:......:|:.::.||....:.
Mouse  1662 AGRDEEQRLAAELREQGQALERRAALLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1726

  Fly  1828 TTSAVNNRDR--------DRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQ 1884
            .|..:|.:.:        ..|.::..|..:.  ..:.|||:....|           .::.|:::
Mouse  1727 NTGLLNQKKKLEVDLAQLSGEVEEAAQERRE--AEEKAKKAITDAA-----------MMAEELKK 1778

  Fly  1885 RLEQVTAGHSVRSTVSTKSEQR-APAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVR 1948
              ||.|:.|..|...:.:...| ..|:||:..:           |::.||              :
Mouse  1779 --EQDTSAHLERMKKTLEQTVRELQARLEEAEQ-----------AALRGG--------------K 1816

  Fly  1949 TQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPE 2013
            .|::::|.|:                                                 |..|.|
Mouse  1817 KQVQKLEAKV-------------------------------------------------RELEAE 1832

  Fly  2014 PD----YRTSSSQVVKEH---VPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWE 2071
            .|    ....:.:.|::|   |...:.:.|.|.....|.|.::......::.:...       :|
Mouse  1833 LDAEQKKHAEALKGVRKHERRVKELVYQTEEDRKNLARMQDLVDKLQSKVKSYKRQ-------FE 1890

  Fly  2072 QAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK-RERERERLYEIRQVERERES 2135
            :||::.|.:.::.|..:...:...:||::        :|.:..| |.|.|:.|           .
Mouse  1891 EAEQQASTNLAKYRKAQHELDDAEERADM--------AETQANKLRARSRDAL-----------G 1936

  Fly  2136 HKVYQP 2141
            .||.||
Mouse  1937 PKVRQP 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 269/720 (37%)
MYSc_Myo15 169..828 CDD:276838 263/699 (38%)
MyTH4 1014..1171 CDD:295320 35/167 (21%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh7bXP_017174700.1 Myosin_N 32..71 CDD:367160
MYSc_Myh7b 98..773 CDD:276953 263/699 (38%)
Myosin_tail_1 853..1930 CDD:366712 244/1324 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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