DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh15

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001159682.1 Gene:Myh15 / 667772 MGIID:3643515 Length:1925 Species:Mus musculus


Alignment Length:2188 Identity:493/2188 - (22%)
Similarity:823/2188 - (37%) Gaps:615/2188 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :||:::|..|:|||:|..||.|||..:|||::|...:|:||||..| .|..||...|..:....:
Mouse    84 IEDLSMLLYLNEASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLP-VYQKEVMAAYKRKRRSEV 147

  Fly   222 PPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITE---- 279
            |||:||:...|...:   ...|.:|.:||||||||.:|||::||.|.:        |.|:|    
Mouse   148 PPHIFAVANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATM--------AAISEPKKK 204

  Fly   280 ------QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKS-GAIVGAKITQYLLEKSRIVTQA 337
                  ||::..|||||||||:|.:|||||||||.:.::|.: |.:..|.|..|.|||||:|.|.
Mouse   205 LGNLEDQIVKMNPLLEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADIQIYFLEKSRVVYQQ 269

  Fly   338 PGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATD---CASGRVDWESL---------Q 390
            |||||||:||::|.|..|..          ....::...:|   |:.|.|..|||         :
Mouse   270 PGERNYHIFYQILSGNQELR----------NMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATE 324

  Fly   391 GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGL 455
            .|:.|||....|:.|..:::.|::|.||:.| :|.||  :|.:|.........||.|:.|.|..|
Mouse   325 KAIDVLGFLPDEKFGCYKLVGAIMHFGNLKF-KRNLR--EEQLEADGTENADKAAFLMGIHASEL 386

  Fly   456 HRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ-KGGTHDAHRIS 519
            .:.|.....:...|.:.....:.|...|..|.::::|..:|.|||:|:|.::. |..:|  ..:.
Mouse   387 LKGLIYPRIKVGNEYVTRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLTSH--FFVG 449

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL 584
            |||..|||.|..||.||||||:.||.||.:||:.:|.|||.||.:|.|:|..:.:..::......
Mouse   450 ILDTTGFEILDYNSLEQLCINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDF 514

  Fly   585 AKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQE-----FGVTHYAGQVWY 644
            .:||:||..:|::|...|:|||..|..|...:|.....|.:.....::     |.:.||||.|.|
Mouse   515 IEKPMGIFSILEEECMLPKATDQMFKTKLFDHHFGKSAYFQTPTSPEKNFEVHFELAHYAGVVPY 579

  Fly   645 CVDGFLDKNRDALRGDVLELL-ASSRLPLVGELTKQL---RAQRDAGKTLPKGSNGRFVTMKPRT 705
            .:.|::.||:..|...|:.|| .||...|....||.:   .|.:...||..||::...:|     
Mouse   580 NISGWIGKNKGLLNETVVALLQKSSNKVLANLFTKDIIAGSASQFGEKTHKKGTSFHLIT----- 639

  Fly   706 PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGY 770
                :...:::.:|:..:....|.|||||.||:.|....||...||||||..|:|:.|::....:
Mouse   640 ----SLHKENINKLMTDLKSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCNGVLEGIRVCCEAF 700

  Fly   771 PVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRAL 835
            |..:.:..|.:||..|.|...:: :.:....:|..|.:....::.|.||.|.|:||.:..:...|
Mouse   701 PSWMLYDDFKQRYWILNPRIFSK-SKFVSSRKATEEVLDFLEIDHPHYQCGVTKVFFKAFILDQL 764

  Fly   836 ESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ 897
            |..|.|::.:.....|...||.|:|   :::...:.|...:|            |.:|.......
Mouse   765 EERRDEKISKVFTLFQARARGKLMRITFQKILEERDALALIQ------------ENIRAFIAVKN 817

  Fly   898 RLWRGR-----------QARRRVQQLRSDHRRRQEAREAAQRAREAREAKQA--VLERSQLSYLD 949
            ..|.|.           .|...:..|:.:..:.|:|.|:::..||..:.||.  |.|::.|. |.
Mouse   818 CPWMGLFFKIKPLAKSVGAGEEIAGLKEECAQLQKALESSESQREELKTKQVSLVQEKNDLR-LQ 881

  Fly   950 IPAE---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLR 1011
            :.||   ||....:.:.         |:|          |.|:|...:.:.|            |
Mouse   882 LQAEQETLANSEEQCES---------LIK----------SKVELEVKIKELS------------R 915

  Fly  1012 LQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLR 1076
            .....|.|.:.|..|.                  |...|:..|..||....:.|:.|:...:...
Mouse   916 QVEEEEEINSELTARG------------------RKLEDECSELKKEIYDLEAILAKSEKGKCAA 962

  Fly  1077 DEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQL 1141
            :..:..|..:||.|                       :...|| |.|.|.| |.|:         
Mouse   963 EHKVRNLTEEVHSL-----------------------NEEVSK-LSRVVKD-AQET--------- 993

  Fly  1142 LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL 1206
              ||                                         :..:.:.::.    |:.:.:
Mouse   994 --QQ-----------------------------------------QTQEQLHIEE----EKLSNM 1011

  Fly  1207 AVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPD 1271
            :.::|.:|           ||:.           :.|.:|      .|....|...:..:..|.|
Mouse  1012 SKANLKLA-----------QQID-----------VLEGDL------ERERKARMKCEREKRKLQD 1048

  Fly  1272 AVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQ-GSSTGQAKSRS 1335
            .:|.         ...|.|::    .|||:.|:..  |.::.||.      || .|.....|::.
Mouse  1049 ELKM---------NQEGAENL----ESSRQKLAEQ--LRKKEFEM------GQMNSKVENEKNQV 1092

  Fly  1336 KSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSA-----------------ERLAPVG 1383
            ..|..::            .:...|.|.|.|...::|...|                 |||...|
Mouse  1093 SQLQKMV------------KELQTHILNLKEELESERTIRAKVEREKGDLVQDLEDLNERLEEAG 1145

  Fly  1384 ----------KDTGPRYQKSQH---AGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLA 1435
                      |....|:||..|   ...|...|:..|...::|:            :.:|.....
Mouse  1146 GTSLAQMEITKQQEARFQKLHHDMEETTRHFEATSASLKKRHAE------------NLAELEGQV 1198

  Fly  1436 SHVRRVR--VPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQE-NEAESEIDDL 1497
            .|:::||  :....||:...:|||.:.|     |:::.|::.|..: .|.||:. |||.:::|::
Mouse  1199 EHLQQVRLVLEQDKSDLQLQVDDLLNRV-----DQMARAKANAEKL-CGLYERRLNEANTKLDEV 1257

  Fly  1498 DDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVA 1562
            ....:|:            .|.|.:|                  :||       ..|.|:.:...
Mouse  1258 TQLAHDL------------TTQKTKL------------------QSE-------SGEFFKRLEEK 1285

  Fly  1563 EGLDKLTSKE-----HLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQ-RAFLQS 1621
            |.|....|:|     .....:|.....:|.....|.|.|.....:.:.....|:::.: :|.|..
Mouse  1286 EALISQLSREKSNFTRQVEELRAQLEEESRSQSALSHALQSAKHDYDLLREQYEEEQEVKAELHR 1350

  Fly  1622 AMAQN---------------LQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSI 1671
            |:::.               :|..:.|....:.|...|.:.|.|...:|:.:             
Mouse  1351 ALSKGNKETVQWRAKYEHDAMQRTEDLEEAKKKLAIRLQEAAEAMEVSNAKN------------- 1402

  Fly  1672 SPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTV--RIG 1734
                    ..::..|..|                   .||..|.      |...|:|::|  .:|
Mouse  1403 --------ASLERARHRL-------------------QLELGDA------LSDLGKARSVAAALG 1434

  Fly  1735 KWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEE 1799
                     :.|..:::...::|.:..:.:...||...:             .|..|:..:.:.:
Mouse  1435 ---------QKQQHSDKALTSWKQKLDETQELLQASQKE-------------TRALSSEVLTFRQ 1477

  Fly  1800 FEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRE----TQDVGQPMQSVVTTKLAKKS 1860
            ...||                   |....|....|:|...:    |..|.:.::::...:.|||.
Mouse  1478 ACEES-------------------TEAQETLKRQNQDLQEQICSLTNQVREGIKNLAEVEKAKKL 1523

  Fly  1861 FEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVR------------STVSTKSEQRAPAKLED 1913
            .|              :..:|::.|||: |.|...|            |....:.|::...|.|:
Mouse  1524 IE--------------QEKTEVQVRLEE-TEGALERNESKILRFQLELSEAKAELERKLSEKEEE 1573

  Fly  1914 TRKL--MLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPP 1976
            ..:|  ..||.:|.|.::           :|..|:.|.:..|:..|:.           |.|...
Mouse  1574 AERLREKHQQAMGSLQSN-----------LDLEASSRIEATRLRKKME-----------GDLKEM 1616

  Fly  1977 APSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQR------- 2034
            ...:.|....:...:.|      ..|.....:....:.|.....::.:||.|....||       
Mouse  1617 EIQLCAANRQVSQMTRA------LGQLQGQMKDLHQQLDDSIYQNKDLKEQVALAEQRTVLLQSE 1675

  Fly  2035 -----------------QERDTFGAVR-------QQQMISSHHLHLE------------------ 2057
                             .|::...|..       |...:.|....||                  
Mouse  1676 LEELRTLQEQTERGRKLAEKELLEATERINLFHTQNTSLLSQKKKLEADVAQVQKEAGEMLQACQ 1740

  Fly  2058 --DHSASSSPAVAA--WEQAERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKEREK 2115
              :..|..:.|.||  .|:.::|:..:....|.|::..:::.|   |.:.....:..||:|:.:|
Mouse  1741 KAEEKAKKTAAEAANMSEELKKEQDTNAHLERMRKNMEQTIKDLQKRLDEAEQTAVLGSKKQIQK 1805

  Fly  2116 -----RERERERLYEIRQ-VERERESHKVYQPAPPRVIQASMD 2152
                 |:.|.|...|:|: .|.:||:.::.:.......||..|
Mouse  1806 LESRVRDLEGELESEVRRSAEAQREARRLERGIKELTYQAEED 1848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 245/714 (34%)
MYSc_Myo15 169..828 CDD:276838 240/694 (35%)
MyTH4 1014..1171 CDD:295320 25/156 (16%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh15NP_001159682.1 Myosin_N 31..69 CDD:280832
Myosin_head 84..757 CDD:278492 245/706 (35%)
MYSc_Myh15_mammals 96..757 CDD:276892 240/694 (35%)
Myosin_tail_1 838..1914 CDD:279860 232/1388 (17%)
NBP1 <1004..>1136 CDD:285709 32/196 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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