DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo3a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_680779.3 Gene:Myo3a / 667663 MGIID:2183924 Length:1621 Species:Mus musculus


Alignment Length:1738 Identity:442/1738 - (25%)
Similarity:706/1738 - (40%) Gaps:479/1738 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 EPWQRG------GGGSVTPSPAQSPSLALLSP----HVLRRQRPASL------------------ 87
            :.|..|      |.|        .|.||.|.|    ..:.|..|..|                  
Mouse   220 DTWSLGITAIELGDG--------DPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCL 276

  Fly    88 -EDFEDLPNLS--AKHPALPSSRLRR--LKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLR 147
             :|:|..|.:|  .||..:.....:.  |:.:..:.:.....|.|...|||.:   :...:|:|.
Mouse   277 TKDYEKRPTVSDLLKHKFITQIEGKDVILQKQLMEFIDIHQCLGSTEKARHER---IHTKKGNLN 338

  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            .........|:|:..||.|.|.::..:|...|.:..||.:.|.||||:||::.. ..|..::::.
Mouse   339 RSLISSLKDVDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSL-GIYSTKLSRL 402

  Fly   213 YAGRPLGSLPPHLFA---IGAAAHAALPSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS 274
            |.|....:.|||:||   :|..:.....:.|.:|||||||:|||||..|::|.|..:   |.:.:
Mouse   403 YIGAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVL---GKANN 464

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.|:||:...|:||||||.|..||||||||||||:.| .|||:|||:|::|||||||::.||.
Mouse   465 RTLQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAI 529

  Fly   339 GERNYHVFYELLGGLSETER-SKYGLLEADKYFYLN-------QGATDCASGRVDWESLQGAMQV 395
            ||:|:|:||.:..||:|.:: :.|.|.|.....||.       |...:.:..:..:|.::...:|
Mouse   530 GEKNFHIFYYIYAGLAEKKKLALYKLPENKPPRYLQNDNLRTVQDMMNNSFYKSQYELIEQCFKV 594

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALT 460
            :|.:..:...:..||||:|::||:.|......:..:...:.:...::.:|.||.|.||.|..|||
Mouse   595 IGFTMEQLGSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSASLLCIQADELQEALT 659

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAH-------RI 518
            |.....|.|.:..|..:::|.|.|||.||.||..||:|:|:.|||:::    ||..       .|
Mouse   660 SHCVVTRGETIIRPNTVEKAADVRDAMAKTLYGRLFSWIVNCINSLLK----HDTSPSGDEELNI 720

  Fly   519 SILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHL 583
            .||||||||:...|||||||||.|||.:|.|||:|||..||.||..|.::...:.::||.|::.:
Mouse   721 GILDIFGFENFKRNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDM 785

  Fly   584 LAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDG 648
            ..:||:|:..|||:||.||:|||.:.:||...| ..|:.:.||:.....||:.||||:|.|...|
Mouse   786 FLQKPMGLLSLLDEESRFPKATDQTLIEKFEDN-LKSQYFWRPKRMELSFGIHHYAGKVLYSASG 849

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGEL---------------TKQL----RAQRDAGKTLPKGS 694
            ||.||||....|::.||.||...::.:|               ||.:    ....:....|.||.
Mouse   850 FLAKNRDTFPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGE 914

  Fly   695 NGRFV------TMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQ 753
            . |.|      |...:|.||::.|..||..||..|....|.||||||||.|:.|.:.|...||.|
Mouse   915 T-RDVTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQ 978

  Fly   754 LRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYR-ELCRALLEAMPRTGVEGPD 817
            ||..|:|:|.:||:.||..|:.|.:|::|| ::|....:...|.. :.|.|:||   :.|::  :
Mouse   979 LRCTGILETARIRRLGYSHRILFANFIKRY-YILCYKSSEEPPVSPDTCAAILE---KAGLD--N 1037

  Fly   818 YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRA 882
            :.||.|:|||:......|...|.|...: .|.:|..||..|                    |.|.
Mouse  1038 WALGKTKVFLKYYHVEQLNLMRKEATNK-LVLIQASVRAFL--------------------GARR 1081

  Fly   883 QQRYERLRK-GALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAK---QAVLERS 943
            .|..::.|| .|:..|     ..|||.:  ||...:.....:.||.|:..|::.:   :...|..
Mouse  1082 YQELQQKRKSSAVIIQ-----SAARRHL--LRKHGKETSNVKSAAGRSIRAKDQEFDYKKNFETK 1139

  Fly   944 QLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN 1008
            :.|::....|.|                        ||...|: ...|.:....|.||       
Mouse  1140 RESFVKKQTENA------------------------VPTNESN-TSTPNNKESPSAGK------- 1172

  Fly  1009 GLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSR 1073
                       |||.  ||.|:..:.:.....:....:.||..| ||..::|   |||....:..
Mouse  1173 -----------TAPF--RAESKATNVESNNRRYHTQKKMSNVYA-EGQNQEL---YIVEDTWAEV 1220

  Fly  1074 GLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLL 1138
            ..|                                         .||:     .:..||      
Mouse  1221 SPR-----------------------------------------QKYV-----QDLEES------ 1233

  Fly  1139 RQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAV---DSW--T 1198
            |::.:::.|.            :.:.::.:|  :|.|.:.        |.|:...:   ::|  |
Mouse  1234 RKMRKEEKGD------------AVIQSYCQW--YTEGSNF--------EESKATCLEGRETWERT 1276

  Fly  1199 SCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAK 1263
            ||                       .|..||:..                               
Mouse  1277 SC-----------------------PGLWLTEEI------------------------------- 1287

  Fly  1264 FARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALN--ERYF-------EREPS 1319
            :.|.||...:.:.:|...|    .|||   :|.:.|  ::::::.|.  ||.:       |.:..
Mouse  1288 YLRKTLDPTLSQKSVYQNA----DGKE---KEHKVS--VVTQNAPLGNLERDYHLLGFLGEEDTG 1343

  Fly  1320 PGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGK 1384
            |.|       ||:...|::.                             ::.:|.|:::...:||
Mouse  1344 PVP-------QAQEEHKAVS-----------------------------IHSKYQSSKKKQQLGK 1372

  Fly  1385 D-TGPRYQ------KSQHAGRRSH------AASHGSHSSKYADKAEYATRSSAMSDTSEAPSLAS 1436
            | ..|.::      .|....:.:|      ....|.|.||..|:     |.|.|:...||..||.
Mouse  1373 DRLAPPFKNQKILSSSTEVAKTTHNVYPCPTKQEGVHHSKMVDE-----RDSKMASKKEAWDLAM 1432

  Fly  1437 HVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYI 1501
            ..|:         :.:..::.|  :|..:|:|:..|:.|.....|                    
Mouse  1433 FSRQ---------ISKLSEEYF--ILQKNLNEIILAQQLKPFYLG-------------------- 1466

  Fly  1502 NDIFQPIPLVQNLEKLTSKDQLAAIIKG--------------GGVASKPEE-------------- 1538
              |::..|:.::   :::...|:.:.||              ....:.||:              
Mouse  1467 --IYRHKPINRH---VSTHQYLSGVSKGEEPKILRPPRRPRKPKTLNNPEDSTYYYLLHKSTQEE 1526

  Fly  1539 -----RDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQ 1598
                 :|.:.::..|:|:..:.|.|...........::|..|:.        ...|.|:      
Mouse  1527 KRRPGKDSQGKLLGLEDFYYKEFLPTHYGPKAHSSNAREWKALK--------EPQAQPI------ 1577

  Fly  1599 LPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQ 1646
                 ||....:......:..:..::.|....::||.:....|.|:.|
Mouse  1578 -----ESNERCWTTSENESLEEERISANPYDYRRLLRKTSQRQRLVQQ 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 276/724 (38%)
MYSc_Myo15 169..828 CDD:276838 269/703 (38%)
MyTH4 1014..1171 CDD:295320 23/156 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myo3aNP_680779.3 PKc_like 10..295 CDD:304357 18/82 (22%)
S_TKc 29..295 CDD:214567 18/82 (22%)
MYSc 345..1060 CDD:214580 277/730 (38%)
MYSc_Myo3 360..1048 CDD:276830 269/703 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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