DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo19

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_079690.2	Gene:	Myo19 / 66196	MGIID:	1913446	Length:	963	Species:	Mus musculus

Alignment Length:	974	Identity:	294/974 - (30%)
Similarity:	462/974 - (47%)	Gaps:	152/974 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 GEGSLRA--RQDLGSS----GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKM 200
            |..||:.  |:.||..    .::|:|.::.:...::|..|:.||.:.:.||.||..|:|:||:|.
Mouse    16 GRASLKGDLREFLGGEIPLHQLDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNPFKH 80

  Fly   201 FPDAYGLEVAKQYAGRPL-GSLPPHLFAIGAAAHAAL-----PSPQVVVISGESGSGKTESTKLV 259
            .|..|..|:.::|...|. ..|.||:|.:|...:..:     |..|.:|:|||||:|||.:::.:
Mouse    81 VPQLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCL 145

  Fly   260 MQYLAAVVPGGGSA-----SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAI 318
            |::.|.|.....|.     :..|.::||.:.|::||||||.|.||.|||||||::::.. ::..:
Mouse   146 MKFYAVVAASPTSCENHKIAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNRAQQM 210

  Fly   319 VGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGAT----DC 379
            .||.:..|||||:|:..||..|||:|:||::..|.::.||.::.|.|...:.:|....:    ||
Mouse   211 TGAAVQTYLLEKTRVACQASSERNFHIFYQICKGATKDERLQWHLPEGTAFSWLPNPESSLEEDC 275

  Fly   380 ASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE---- 440
                  :|..:.||..||:....:..|.:|||.:||||||:|             |.|:.|
Mouse   276 ------FEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHF-------------VDSEDEALPC 321

  Fly   441 ---------IKWAAHLLHISADGLHRALTSRTTEARAER--LHTPLGIDQALDARDAFAKALYAG 494
                     ::.:|.||.:....|..::..||.:|..::  ...|....:....||..||.:||.
Mouse   322 QVMDDTKVSVRTSALLLQLPEKMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIYAR 386

  Fly   495 LFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            ||:||||.|||.:..........|.:||::|||....||.||||||||||.||.:|..|..:.:|
Mouse   387 LFDWLVSVINSSICADSKSWTAFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQ 451

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYA 624
            .||..|.|||:.:.:.||...:.||...|:.||.|:::|....|.:..:.|:    ....|.|..
Mouse   452 EEYEVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQ----TRIESTLAG 512

  Fly   625 RPRIGAQE------FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQ 683
            ||.:|..:      |.|.|:||.|.|...|.::||:|.:..::.|||..|:.||   ||....|.
Mouse   513 RPCLGHNKLSREPSFVVVHFAGPVRYHTAGLVEKNKDPVPPELTELLQQSQDPL---LTMLFPAN 574

  Fly   684 RDAGKTLPKGSNGRFVTMKPRTP--TVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMD 746
                   |:......::.:.|.|  ||.::|..||:||||.:....|.::||||||.:.......
Mouse   575 -------PEEKTQEELSGQSRAPALTVVSKFKASLEQLLQVLHNTTPHYIRCIKPNSQSQPQTFL 632

  Fly   747 MPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHL------LPSPL-----ARGTPYREL 800
            ...||.||...|:::||.|...|:|:|:..|:|:|||:.|      :.|.|     |.|:..:.|
Mouse   633 QEEVLNQLEACGLVETIHISAAGFPIRVSHQNFIERYKLLRRLGPRMSSGLGGLEPAEGSSEQPL 697

  Fly   801 C----------RALLEAMP---RTGVEGPD--------YQLGATRVFLREALHRALESGRTERLR 844
            |          :.:|.|:|   :|.....|        ...|.|::|:.:::...||.||.:.|.
Mouse   698 CAKEATLQPLLQDILHALPALIQTAATPSDPAKNTQIPLYCGRTKIFMTDSMLELLECGRAQMLE 762

  Fly   845 RAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRV 909
            :.|..:|...|...:::|..:|:||.. :||.:|....::...||...|...:..|
Mouse   763 QCARCIQCGWRRHRLQKQEKQRRAAVL-IQAAFRSWLTRKHIRRLHIAATVIKHAW--------- 817

  Fly   910 QQLRSDHRRRQEAREAAQRAREAREAK---QAV-LERSQLSYLDIPAELAFIYSKLQGWSPPHG- 969
                  |:.|......|.:..:..|.|   ||. ..||.:|    ||...|:.:.:..|  |.|
Mouse   818 ------HKWRIRMACLASKELDGMEEKPMPQAPGTLRSSMS----PAHTRFLGAIIHLW--PLGL 870

  Fly   970 ------------DRHLV--KVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPI 1019
                        .|.||  ..|......||:.||.|:. .|.......::....::...|:.|:
Mouse   871 VLANSADGVRGFQRKLVAHACLRLPSDRPSNKVQTPQQ-DQAGITSIRALPQGSIKFHCRKSPL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	241/750 (32%)
		MYSc_Myo15	169..828	CDD:276838	239/729 (33%)
		MyTH4	1014..1171	CDD:295320	2/6 (33%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	239/729 (33%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	602..624		11/21 (52%)
		IQ	784..804	CDD:366194	6/20 (30%)
		MyMOMA region. /evidence=ECO:0000250\|UniProtKB:Q96H55	829..963		25/112 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910