DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and myhz1.1

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001108561.1	Gene:	myhz1.1 / 58142	ZFINID:	ZDB-GENE-000322-5	Length:	1937	Species:	Danio rerio

Alignment Length:	2200	Identity:	494/2200 - (22%)
Similarity:	836/2200 - (38%)	Gaps:	604/2200 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
Zfish    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA 152

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|::...|:..:.:.   |.|:|:||||:|||.:||.|:||.|.|...|         |...
Zfish   153 PPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQ 217

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||:|||:|.||||||||||::.::| .||.:..|.|..|||||||:..|.|
Zfish   218 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLP 282

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQ 394
            .||.||:||:::.. .:.|..:..|:..:.|.:     ..|:.|::      |.|.|   ..|:.
Zfish   283 DERGYHIFYQMMTN-HKPELIEMTLITTNPYDF-----PMCSQGQITVASIDDKEELVATDTAID 341

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            :||.:..|:.||.:...||||.||:.|.::|   .:|..|.....|.....:||.:::..:.:||
Zfish   342 ILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKIGYLLGLNSADMLKAL 403

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|..::..|.:|::|..:|.|:|.|||.::......:.. |.:|||.
Zfish   404 CYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFF-IGVLDIA 467

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:.|..:.:..:|.....|.:||:
Zfish   468 GFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL 532

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDG 648
            ||..:|::|..||:|||.||..|.:..| |.:..|    :|..|..|  |.:.||||.|.|.:.|
Zfish   533 GIFSILEEECMFPKATDTSFKNKLYDQH-LGKCNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISG 596

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            :||||:|.|...|::|...|.:.|:..|...:..:...||   ||...:..:|:    ||:::|.
Zfish   597 WLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGK---KGGKKKGGSMQ----TVSSQFR 654

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            ::|.:|:.::...||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..
Zfish   655 ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 719

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||:.|..|.:..| .:.:..:|..:.:....|...:|:.|.|:||.:..|...||..|.|:|
Zfish   720 FKQRYKVLNASVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKL 783

  Fly   844 RRAAVSVQRHVRGMLVRRQ----LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            .......|...|..|:||:    :.||.|..| :|         ..|...:...:.:.|.|.|.|
Zfish   784 ASLVTMTQALCRAYLMRREFVKMMERRDAIYT-IQYNVRSFMNVKHWPWMKVYYKIKPLLKSAET 847

  Fly   896 AQRLWRGRQARRRVQQLRSDH-RRRQEAREAAQRAREAREAKQAVLERS---QLSYLDIPAELAF 956
            .:.|          ..::.|. :.:::..:|..:.:|..|...|:|:..   ||:.......|:.
Zfish   848 EKEL----------ATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSD 902

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
            ...:.:|         |:|          |.:||...|.:.:           .||:...| |.|
Zfish   903 AEERCEG---------LIK----------SKIQLEAKLKETT-----------ERLEDEEE-INA 936

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQ 1086
            .|..:                                             .|.|.||     |::
Zfish   937 ELTAK---------------------------------------------KRKLEDE-----CSE 951

  Fly  1087 VHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSS 1151
                                              |.:.:||
Zfish   952 ----------------------------------LKKDIDD------------------------ 958

  Fly  1152 GAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAALAVSSLGVA 1214
                                        |.|||.....:..|.::...  .||.|| ...|:|..
Zfish   959 ----------------------------LELTLAKVEKEKHATENKVKNLTEEMAA-QDESIGKL 994

  Fly  1215 SRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVP 1279
            ::....:.:..||..|        ||.||:           |.:.:..| ::|.|...|
Zfish   995 TKEKKALQEAHQQTLD--------DLQAEE-----------DKVNTLTK-SKTKLEQQV------ 1033

  Fly  1280 PPAPPTSSGKEDVPRERRSSREL---LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL 1341
                      :|:.......::|   |.|:    :|..|             |..|...:|:.||
Zfish  1034 ----------DDLEGSLEQEKKLRMDLERA----KRKLE-------------GDLKLAQESIMDL 1071

  Fly  1342 LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHG 1406
                                       .||:..|.|:|..  ||    ::.||...:.....|.|
Zfish  1072 ---------------------------ENDKQQSEEKLKK--KD----FETSQLLSKIEDEQSLG 1103

  Fly  1407 SHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSD 1471
            :...|..  .|...|...:.:..||...|    |.:|..|.:|            |...|:|:|:
Zfish  1104 AQLQKKI--KELQARIEELEEEIEAERAA----RAKVEKQRAD------------LSRELEEISE 1150

  Fly  1472 ARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAII----KGGGV 1532
            ....|........|...:.|:|           ||  .|.::||:.|.:.:..|..    :...|
Zfish  1151 RLEEAGGATAAQIEMNKKREAE-----------FQ--KLRRDLEESTLQHEATAAALRKKQADSV 1202

  Fly  1533 ASKPEERD-----------EESEIE-DLDDYINELFEPIPVAEGLDKL--TSKEHLAVSIRGGGS 1583
            |...|:.|           |:||.: ::||..:.:.........|:|:  |.::.|: .|:  ..
Zfish  1203 AELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLS-EIK--SK 1264

  Fly  1584 TDSNGADPLLHQLMQLPG-----ETESG---------PALYQQ--QVQRAFLQSAMAQNLQIQQQ 1632
            .|.|     |.|:..|..     :||:|         .||..|  :.::||.|.......||:::
Zfish  1265 NDEN-----LRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEE 1324

  Fly  1633 LLAQN---QALQT------LL------SQQAAA------AAANNST----SPPPAPPILSSLSIS 1672
            :.|:|   .|:|:      ||      .|:|.|      :.||:..    :......|..:..:.
Zfish  1325 VKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1389

  Fly  1673 PPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWR 1737
            ....:...|::.....:..:.|                :|....:|:..|.  |..:.:.|...|
Zfish  1390 ESKKKLAQRLQEAEEQIEAVNS----------------KCASLEKTKQRLQ--GEVEDLMIDVER 1436

  Fly  1738 ---------------------WPPPQDEPQFQTEE--------DFFAFKMRQHQRKTTPQAQHHQ 1773
                                 |....:|.|.:.|.        ....|||:....:|..|.:..:
Zfish  1437 ANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLK 1501

  Fly  1774 MTSNGGMMESGP-----GARG-------ASATAIEWEEFEIESP------TPPPMSGQLMRSSIR 1820
            ..:.....|...     |..|       .|..|:|.|:.||::.      |......:::|..:.
Zfish  1502 RENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLE 1566

  Fly  1821 LETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKL-- 1878
            |....:.....:..:|.:     |.:|.:...|||.:.:::..::..:...:...|.:.::::
Zfish  1567 LNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQL 1631

  Fly  1879 ------SSEMRQRLEQVTAG------HSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVS 1931
                  ::|.:::|..|.|.      | :...|..:.:.:....:.:.|..::|.::..|.|::.
Zfish  1632 SHANRQAAEAQKQLRNVQAQLKDAQLH-LDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALE 1695

  Fly  1932 ----GGNSGPGGVVDSHATV------RTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPP 1986
                |.......:||:...|      .|.:...:.||...           |:.....|
Zfish  1696 QTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEAD-----------LVQIQSEV------ 1743

  Fly  1987 IRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTF----------- 2040
                          ..:...||:.|.:.....:.:.::.|.:     ::|:||.
Zfish  1744 --------------EDTVQEARNAEDKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNLE 1789

  Fly  2041 -------------------GAVRQQQMISSHHLHLED-------HSASSSPAVAAWEQAERERSR 2079
                               |..:|.|.:.|....||.       ..|.:...|..:|:..:|.:.
Zfish  1790 VTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTY 1854

  Fly  2080 SRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERE 2134
            .....:...:..:.:.|:.:::..|....||   |..|:....|.::|:|:.|.|
Zfish  1855 QTEEDKKNVNRLQDLVDKLQLKVKAYKRQSE---EAEEQANSHLSKLRKVQHELE 1906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	248/706 (35%)
		MYSc_Myo15	169..828	CDD:276838	242/686 (35%)
		MyTH4	1014..1171	CDD:295320	12/156 (8%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myhz1.1	NP_001108561.1	Myosin_N	36..74	CDD:280832
		Myosin_head	89..768	CDD:278492	247/698 (35%)
		MYSc_class_II	101..768	CDD:276951	242/686 (35%)
		Myosin_tail_1	848..1925	CDD:279860	225/1419 (16%)
		SPEC	881..1043	CDD:295325	50/365 (14%)
		MIT_CorA-like	<1297..>1409	CDD:294313	21/111 (19%)
		TMPIT	1473..>1583	CDD:285135	17/109 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000