DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYH7B

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_016883475.1 Gene:MYH7B / 57644 HGNCID:15906 Length:2003 Species:Homo sapiens


Alignment Length:2347 Identity:576/2347 - (24%)
Similarity:909/2347 - (38%) Gaps:594/2347 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDWAEGDLVWFDPGMGHPIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPW------------ 53
            :.||..:|..|...:.||....:.:|....:  ..:.|.:|...:.:.|..||            
Human    21 LPWAALNLQGFQLLLLHPSATAMMDVSELGE--SARYLRQGYQEMTKVHTIPWDGKKRVWVPDEQ 83

  Fly    54 ---------QRGGGGSVTPSPAQSPSLALLSPHVLRRQRPASLEDFEDLPNLSAKHPALPSSRLR 109
                     ....||.||........|.:         |.|.|:..                   
Human    84 DAYVEAEVKSEATGGRVTVETKDQKVLMV---------REAELQPM------------------- 120

  Fly   110 RLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWN 174
                                   :|..|.|                 :|||.::..|:|||:|.|
Human   121 -----------------------NPPRFDL-----------------LEDMAMMTHLNEASVLHN 145

  Fly   175 LRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL--- 236
            ||.||.:.:|||::|...:.:||||..| .|...|...|.|:.....|||::|:...|:..:   
Human   146 LRQRYARWMIYTYSGLFCVTINPYKWLP-VYTASVVAAYKGKRRSDSPPHIYAVADNAYNDMLRN 209

  Fly   237 PSPQVVVISGESGSGKTESTKLVMQYLAAVV-----PG----------GGSASAVITEQILEAAP 286
            ...|.::|:||||:|||.:||.|:||.|.|.     ||          ||:    :.:||:||.|
Human   210 RDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGT----LEDQIIEANP 270

  Fly   287 LLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELL 350
            .:||||||:|.||||||||||::.::| .||.:..|.|..|||||||::.|.||||:|||:|::|
Human   271 AMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGERSYHVYYQIL 335

  Fly   351 GGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQVLGVSEGEREGI 406
            .| .:.|.....||..:.|.|     ..|:.|.:      |.|.|   ..||.:||.|..|:...
Human   336 SG-RKPELQDMLLLSMNPYDY-----HFCSQGVITVDNMNDGEELIATDHAMDILGFSVDEKCAC 394

  Fly   407 VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            .:::.|:||.||:.|.::|   .:|..|.........||:|:.:|:..|.:.|.........|.:
Human   395 YKIVGALLHFGNMKFKQKQ---REEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYV 456

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-----ISILDIFGFEDLAE 531
            .....::|.:.|..|.|||.|..||.|||||||.      |.|...     |.:|||.|||....
Human   457 TKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQ------TLDTKLPRQFFIGVLDIAGFEIFEF 515

  Fly   532 NSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--------- 586
            |||||||||:.||.||.:||:|:|.|||.||.||.::|..:.:. |..|.|.|:.|         
Human   516 NSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKVRRLRLSDV 580

  Fly   587 ----------KPVGICHLLDDESNFPRATDLSFLEKCHYNHA-LSELYARPRIGAQ-----EFGV 635
                      :|:||..:|::|..||:|:|.||..|.:.||| .|..:.:||...:     .|.|
Human   581 GGPHSYSFCSQPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEV 645

  Fly   636 THYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG--KTLPKGSNGRF 698
            .||||.|.|.:.|:|:||:|.|...|:.:...|:..|:..|.:..     ||  .|.|..|..:.
Human   646 VHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENY-----AGSCSTEPPKSGVKE 705

  Fly   699 VTMKPRT-PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDT 762
            ...|..: .||:....::|.:|:.::....|.|||||.||:.|....||...||.|||..|:|:.
Human   706 KRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEG 770

  Fly   763 IQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFL 827
            |:|.::|:|.||.:..|.:|||.|.||.:...| :.:..:|..:.:....::...||.|.|:||.
Human   771 IRICRQGFPNRLLYTDFRQRYRILNPSAIPDDT-FMDSRKATEKLLGSLDLDHTQYQFGHTKVFF 834

  Fly   828 REALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQAAATRLQARWRGQRAQQRYER 888
            :..|...||..|.:||.:....:|...||.|:|    |.|..|.|..| :|...|...|.:.:..
Human   835 KAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFT-IQWNIRAFNAVKNWSW 898

  Fly   889 LRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAE 953
            : |.....:.|.|..||...:..||::.|..:.|..||       |||:..||.:.:|......:
Human   899 M-KLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAA-------EAKRQELEETHVSITQEKND 955

  Fly   954 LAFIYSKLQGWSPPHGDRH-----LVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQ 1013
            ||.   :||.......|..     |:|          |.|||...:.:.|           .||:
Human   956 LAL---QLQAEQDNLADAEERCHLLIK----------SKVQLEGKVKELS-----------ERLE 996

  Fly  1014 PRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL---EGAKEKLLADYIVHKALSSRGL 1075
            ...| :.|.|    |:|.:..:|.....|..:   :|..|   :..|||...:..|.........
Human   997 DEEE-VNADL----AARRRKLEDECTELKKDI---DDLELTLAKAEKEKQATENKVKNLTEEMAA 1053

  Fly  1076 RDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRF---VDD-----EAPES 1132
            .||.:.:|..:...|.    ||.:  |.||.........:|.:|..:|.   |:|     |..:.
Human  1054 LDESVARLTKEKKALQ----EAHQ--QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKK 1112

  Fly  1133 LRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW 1197
            ||....|...:.:|                                  .|.|..|:....|.|. 
Human  1113 LRMDTERAKRKLEG----------------------------------DLKLTQESVADAAQDK- 1142

  Fly  1198 TSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIA-----EKELCPAFPAPRSDL 1257
            ...||......|.|...|    |.::| :||..:.....:.:|.|     |:|| .|..|.|:.:
Human  1143 QQLEEKLKKKDSELSQLS----LRVED-EQLLGAQMQKKIKELQARAEELEEEL-EAERAARARV 1201

  Fly  1258 LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRER-----RSSRELLSRS-------SALN 1310
            .:..|:.|| .|.:..:|   ...|...|:|:.:..|:|     |..|||...:       :||.
Human  1202 EKQRAEAAR-ELEELSER---LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR 1262

  Fly  1311 ERYFEREPSPGPGQGS--STGQAKSRSKS-----LDDLLAGDIVPVPTDCDSQEPLHTLGLSESR 1368
            .:..|.....|....|  ...|...:.||     :|||.|.              :.||..::: 
Human  1263 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN--------------VETLTRAKA- 1312

  Fly  1369 LNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPS 1433
                  |||:|....:|                      ..|:...|.|...|..|.:.|     
Human  1313 ------SAEKLCRTYED----------------------QLSEAKIKVEELQRQLADAST----- 1344

  Fly  1434 LASHVRRVRVPSQASDVDQFLDD---LFSPVLDG------SLDEL-------SDARS-LAASIRG 1481
                 :|.|:.:::.::.:.|::   |.|.:..|      ||:||       |.|:| ||.:::.
Human  1345 -----QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 1404

  Fly  1482 ---------GSYEQENEAESEIDDLDDYIN-DIFQ-----PIPLVQNLEKL-TSKDQLAAII--- 1527
                     ..:|:|.||::|:..|....| ::.|     ....:|..|:| .:|.:||..:   
Human  1405 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1469

  Fly  1528 -KGGGVASKPEERDEESEIE---DLDDYINELFEPIPVAEGLDKLTSKEHLAVSIR--------- 1579
             :|...|:......|::::.   :.:|...||......|..|||  .:.||..::.         
Human  1470 EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK--KQRHLERALEERRRQEEEM 1532

  Fly  1580 ----GGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQ---SAMAQNLQIQ----QQL 1633
                .....:|.|....|.:|..  |..|:..||...:.:...||   |.:...:.:.    |:|
Human  1533 QRELEAAQRESRGLGTELFRLRH--GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQEL 1595

  Fly  1634 LAQNQALQTLLSQ-QAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRM--------KATRSSL 1689
            ....:||:...|: |||...|..:........:...|.:|....:...::        ...|:..
Human  1596 EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ 1660

  Fly  1690 VVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD-EPQF-----Q 1748
            ..:||||               ....:|||      .|.:.:|:.|.......| |.|.     |
Human  1661 RAVESLQ---------------ASLDAETR------ARNEALRLKKKMEGDLNDLELQLGHATRQ 1704

  Fly  1749 TEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPG-ARGASATAIEWEE----FEIESPTPP 1808
            ..|...|.::.|.|.|.....:..:......:.|.... .|.||..|.|.||    .|....:..
Human  1705 ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1769

  Fly  1809 PMSGQLMRSSIRLETTTTTTTSAVNNRDR--------DRETQDVGQPMQSVVTTKLAKKSFEIGA 1865
            ....:|:.::.||....:..|..:|.:.:        ..|.::..|..:.  ..:.|||:....|
Human  1770 LAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE--AEEKAKKAITDAA 1832

  Fly  1866 DRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQR-APAKLEDTRKLMLQQQLGGLFAS 1929
                       .::.|:::  ||.|:.|..|...:.:...| ..|:||:..:           |:
Human  1833 -----------MMAEELKK--EQDTSAHLERMKKTLEQTVRELQARLEEAEQ-----------AA 1873

  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994
            :.||              :.|::::|.|:                                    
Human  1874 LRGG--------------KKQVQKLEAKV------------------------------------ 1888

  Fly  1995 PAPPPAPQSPPTARSPEPEPD----YRTSSSQVVKEH---VPAFIQRQERDTFGAVRQQQMISSH 2052
                         |..|.|.|    ....:.:.|::|   |.....:.|.|.....|.|.::...
Human  1889 -------------RELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1940

  Fly  2053 HLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK-R 2116
            ...::.:...       :|:||::.:.:.::.|..:...:...:||::        :|.:..| |
Human  1941 QSKVKSYKRQ-------FEEAEQQANTNLAKYRKAQHELDDAEERADM--------AETQANKLR 1990

  Fly  2117 ERERERL 2123
            .|.|:.|
Human  1991 ARTRDAL 1997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 269/741 (36%)
MYSc_Myo15 169..828 CDD:276838 263/720 (37%)
MyTH4 1014..1171 CDD:295320 32/167 (19%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH7BXP_016883475.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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