Protein Alignment Myo10A and myo1g

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_005170126.1
• Gene: myo1g / 571487
• ZFINID: ZDB-GENE-060503-562
• Length: 1010
• Species: Danio rerio
• Alignment Length: 1061
• Identity: 315/1061 - (29%)
• Similarity: 485/1061 - (45%)
• Gaps: 231/1061 - (21%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |..|..|||::.....:.||:||::|..||||.|.::::||||:.. |.||.:|.:.|.||.|..
Zfish    10 GKSDFVLLDEVTMEQFMENLKLRFEKSRIYTFIGEVVVSVNPYRHL-DIYGKDVIEDYRGRELYE 73

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSASAVITEQI 281
            .||||:|:..||:.|:   .....:|||||||:||||::|.:|||:||:. |...:....:...:
Zfish    74 NPPHLYAVADAAYKAMKRRAKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVESVKNVL 138

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |::..:|||||||:|.|||||||||||:::.|. :|...|..|..|||||||:|.|..||||:|.
Zfish   139 LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFNFNGDPTGGHINNYLLEKSRVVQQQEGERNFHS 203

  Fly   346 FYELL-GGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREGI 406
            ||:|| ||..:..:|.|...:..:|.|.:|||:...:...|   .:::..|::|:|.:..|...|
Zfish   204 FYQLLRGGSDDLLKSLYLQRDPAEYTYTSQGASVTLASNNDSQCHKAVMAALKVIGFTAEEISSI 268

  Fly   407 VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARA--- 468
            .:.|:.:|||||:.|    ...|:..|.||.|. :|..:.|.....:...:||..||.....
Zfish   269 YKTLSTILHLGNLQF----TSDGEHVVLVGEDM-LKNISELTSTEPENTRKALLYRTVATGGGEV 328

  Fly   469 -ERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-----ISILDIFGFE 527
             |:.|:.   .:|...|||||||||..||.|:|.|||.:::....:.|..     |.:|||:|||
Zfish   329 IEKGHSE---QEASYGRDAFAKALYERLFAWIVGRINGVIEVKDYNPALHGKNTVIGVLDIYGFE 390

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGIC 592
            ....|||||.||||.||.||..|.:.:.:.||.||.||.:.|..:.:.:|..::.|:.:...||.
Zfish   391 IFDNNSFEQFCINYCNEKLQQLFIELILRQEQEEYQREGITWQHIEYFNNQIIVDLVEQPHKGII 455

  Fly   593 HLLDDESNFP-RATDLSFLEKC--------HYNHALSELYARPRIGA-------QEFGVTHYAGQ 641
            .:||:..... :.||...|:..        ||.       :|....|       ::|.:.||||.
Zfish   456 SVLDEACLIAGKVTDTVCLDSMNKKLGQHPHYT-------SRKLCPADKTMEFNRDFRIRHYAGD 513

  Fly   642 VWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTP 706
            |.|.||||||||:|.|..|...|:.:|..|::.|:             .|.|...  :|...:.|
Zfish   514 VTYSVDGFLDKNKDPLFQDFKRLMYNSSDPVLKEM-------------WPDGKMS--ITEVTKRP 563

  Fly   707 -TVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGY 770
             |.|..|.:|:..|:..:....|::|||||||:.|..|..|......|:.|||:|:.:::|:.|:
Zfish   564 LTAATLFKNSIIALVDKLACKEPYYVRCIKPNEVKSPLLFDDGRCQHQVAYLGLLENVRVRRAGF 628

  Fly   771 PVRLRFQHFVERYR---------HLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVF 826
            ..|..:..|::||:         ||:.:.       :|...|::.   :.|.| .|...|..::|
Zfish   629 AYRQPYARFLQRYKMTCEYTWPNHLMSTD-------QEAVEAIVN---QHGFE-DDVAYGLNKIF 682

  Fly   827 LREALHRALESGRT----ERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYE 887
            :|        :.||    |:.|.|.:.:       ||
Zfish   683 VR--------TPRTLFTLEQERAALIPI-------LV---------------------------- 704

  Fly   888 RLRKGALTAQRLWRGRQARRRVQQLRSDH-------------------RRRQEAREAAQRAREAR 933
                  |..|::|||..||.|.:::|:.:                   ||....|..|...:
Zfish   705 ------LFLQKVWRGALARMRCRKIRAIYTIMGYYKCYKVKAHFWEVERRFASVRNMADYGK--- 760

  Fly   934 EAKQAVLERSQLSYLDIPAELAFIYSKLQ-----GWSPPHGDRHLVKVLGTVPGPPSSAVQLPED 993
                      .:.:...||.||..:...|     .|:     |.|:|.:     |||...::...
Zfish   761 ----------SVEWPTPPAALAQFHRITQHLYRRWWA-----RQLIKNI-----PPSDMAEVRAK 805

  Fly   994 LGQFS--------FGKFSSVYCNGLRLQPRREPITAPLLTRAA----SRDQDFQDALAVFKLILR 1046
            :..||        :| :|..:........:..|:.:....|..    ::||..|...:....:|.
Zfish   806 VAAFSALSGERMDWG-YSRSWERDYLANAKDSPLMSSNFVRITKELKNKDQYGQVLFSSAVRMLN 869

  Fly  1047 WSN---DKA----------LEGAK-----EKLLADYIVHKALSS---------RGLRDEILVQLC 1084
            |.|   |:|          ||..|     :::..|.:|..:::|         ...:|:.||.|
Zfish   870 WFNNTKDRALLITDKHIYRLEPKKHFKVQKRIALDSVVGLSVTSGSDQLVVLHTATQDDFLVHL- 933

  Fly  1085 NQVHGLPPNSGEATRLWQLLG 1105
             |...|.||.   .|:.:|:|
Zfish   934 -QRGQLNPNQ---DRVGELVG 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	246/702 (35%)
		PTZ00121	<828..>943	CDD:173412	21/137 (15%)
		MyTH4	1014..1171	CDD:470587	27/123 (22%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo1g	XP_005170126.1	MYSc_Myo1	23..684	CDD:276829	246/702 (35%)
		Myosin_TH1	805..1002	CDD:461801	31/152 (20%)