DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and si:ch211-18i17.2

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_700015.5	Gene:	si:ch211-18i17.2 / 571341	ZFINID:	ZDB-GENE-030131-5404	Length:	761	Species:	Danio rerio

Alignment Length:	796	Identity:	157/796 - (19%)
Similarity:	268/796 - (33%)	Gaps:	244/796 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2510 HQQQQQQQQLEDAMEEQHMATDHQQQQ---QQQLGQQQG--------QQQRFLKQQSYLHSARKS 2563
            |.::::::..|...:::|..|...|.:   .|......|        :::|.|..|.     .|.
Zfish    23 HGEKEEEESFELRNQDEHTHTGRGQLEVTLSQPTRSANGTPCLSGVPEEKRSLITQK-----TKM 82

  Fly  2564 NAGQQPSSLTNGQVHHQEQ--MLQQQQ----QQSQSLPHH---DLDANYLQDESNGGT------- 2612
            ...:.|..:..|.:..:.|  .|:|::    ..|.||.::   |.||..|      ||
Zfish    83 TMDEDPEVVVKGWLLREVQGGWLRQRRFWFVLTSDSLDYYSGPDRDARRL------GTLVLTSLC 141

  Fly  2613 ----PPSVT-----KYSLLQFAMQHFRNDQLRDADRHHER--HQSAA------------------ 2648
                |...|     .:||..:..:|.    .|...:|:..  |.:.|
Zfish   142 SVLWPDKHTYKQTGYWSLTVYGRKHC----YRLFTKHYNEAVHWACAVQKVIDSKAPVETPTQLL 202

  Fly  2649 ------NRSYAELV----------KWQGHAIRLPLLRLP--------------NDLAPLALECFD 2683
                  |:...|:|          ::....:..|||..|              ..:...|:..|:
Zfish   203 IRDIEENKFNPEVVEHIYQHNPILRYTQSPLYAPLLPFPYGSLHHTHMASKGYTSIREEAVRLFN 267

  Fly  2684 CILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPC-----PDSSQRA 2743
            |:.:      |:.....:..:..:|..|.....||||:||||:|||:...|..     |:...|.
Zfish   268 CLQQ------LESAREPIPLIQGILQTCLDLRPLRDELYCQLIKQTSTTSSRVQTQTNPNPQLRY 326

  Fly  2744 WRLLSILAAYFGCSDALRPYLMEHLTSAAS-------DRRRSCHGTAAVCLTNLRKTARCGGRKN 2801
            |:||:.::..|..|..:..||..||....|       :...|..|.|      |.||.   ||:.
Zfish   327 WQLLTCMSCTFLPSCGILRYLRFHLKRVQSLSVDPEVESYASFIGQA------LEKTR---GREC 382

  Fly  2802 VPSVEEVTAVSAGRSARRQI-----YRLPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQE 2861
            |||.||:    .|...|::|     |..||..:..:.:.  |...:|:.::...||::.  .:..
Zfish   383 VPSWEEI----QGLMGRQEILCTVHYPGPGCCQIPITSH--TTANEVVRKMAERLGLQD--SRNT 439

  Fly  2862 FSLYCIVQGDAFTMPLAADEYILDVTT--ELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVL 2924
            |.|:  .|...:...:.....|.||.|  |.|.:..|.....||..:           .||..:.
Zfish   440 FGLF--EQNACWEKAIGGSTIIADVITRFENLSAKDPDSDCQCRLCF-----------KLYCLLD 491

  Fly  2925 FNQVAPDYLEGLLL-----ELPGNGVPVPEMVRDMARIAA-----LLHRAADLSHVPAMKEI--- 2976
            ...::.|.:|.|.|     |:...| .:|....|:..:||     ||...:.||..||::::
Zfish   492 TENISTDSIEYLFLYEQCHEMVVRG-QLPACEEDLLSLAALRLQYLLGDFSALSPYPALEQLFPA 555

  Fly  2977 ------KFLLPKPALG-----------------------------IREIRPAQWVGLVQSAWPQV 3006
                  ..|.|....|                             :|| ..|..:..:...|..:
Zfish   556 EVVEARALLAPVDPPGCPSFPGGLLAGTLWGHKRRQEQDQRLRARLRE-EGAVVMSTILERWKAL 619

  Fly  3007 ANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDL---ILALNRRGVLF 3068
            ...|.....|.:|.:...|..||.:.:.|....:..|...:    .:|..:   .:.|.|:|
Zfish   620 VGYSGRDSMAAYLTIARQWSGFGCTLYEVDFYISSTGSFSQ----KLWLGVAASCVTLYRQG--- 677

  Fly  3069 LDPNTHETLQHWSFMEVIS-------TRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRL 3126
                ..|.|:.....::.|       |.::.:.|               |.:..:|.:..||.:|
Zfish   678 ----EAEALESLPITQICSYGVSDSNTFRITAGD---------------RDLLFETTKLTEIMQL 723

  Fly  3127 VRQYI--TMAQISQRD 3140
            :..|.  |..|:.:.|
Zfish   724 MNAYFSATRRQLGKDD 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580
		MYSc_Myo15	169..828	CDD:276838
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165	39/117 (33%)
		B41	2823..3033	CDD:214604	49/259 (19%)
		FERM_B-lobe	2920..3025	CDD:271216	27/152 (18%)
		FERM_C_MyoXV	3029..3138	CDD:270022	20/120 (17%)
si:ch211-18i17.2	XP_700015.5	PH-like	86..199	CDD:302622	23/122 (19%)
		PH	90..>177	CDD:278594	20/96 (21%)
		MyTH4	282..390	CDD:279165	39/120 (33%)
		B41	400..646	CDD:214604	50/264 (19%)
		UBQ	405..>445	CDD:294102	8/45 (18%)
		FERM_M	494..646	CDD:278785	29/153 (19%)
		PH-like	642..733	CDD:302622	19/116 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710