DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo10l1

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_001924041.3 Gene:myo10l1 / 566674 ZFINID:ZDB-GENE-080425-1 Length:2041 Species:Danio rerio


Alignment Length:3181 Identity:664/3181 - (20%)
Similarity:1054/3181 - (33%) Gaps:1376/3181 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 GEGSLRARQDLGS----------------------SGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            |:|:|....|.|.                      .|||||:.|.:||||:::.||..||.|..|
Zfish    28 GDGNLVLTTDYGEVVYLQQAEVNREKVSAMHQSSIDGVEDMSTLAELHEAAIMHNLHQRYQKDNI 92

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||..||||.||||||.....|.|...:.|:...||.||||:|||....:..|   ...|.|:|||
Zfish    93 YTNIGSILAAVNPYKQIKGLYDLSAVELYSQHHLGELPPHIFAIANECYRCLWKRHDSQCVLISG 157

  Fly   247 ESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQ-------ILEAAPLLEAFGNARTARNDNSSR 304
            |||:||||||||::|:|:  |....||....||:       |::::|::||||||:|..|:||||
Zfish   158 ESGAGKTESTKLLLQFLS--VMSQNSAGTPPTEKSTRVEQAIVQSSPIMEAFGNAKTVYNNNSSR 220

  Fly   305 FGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADK 368
            |||:::::| :||.|.|..|..|||||:|:|.|.|||||||:||.||.|.|::|:..|.|.::.:
Zfish   221 FGKFIQLHFSQSGNIQGGCIVDYLLEKNRVVRQNPGERNYHIFYALLAGASKSEKETYFLEDSPE 285

  Fly   369 YF-YLNQGATDCASGR-VD----WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLR 427
            .| ||:|  :.|...| :|    ::.:..|::|:..:|.|...:.::|:.||.||||.|    :.
Zfish   286 LFHYLSQ--SGCVKDRSLDDKKLFDDVMEALKVMEFTEEEIRDMFKLLSGVLQLGNVEF----MT 344

  Fly   428 HGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALY 492
            .|  |.::.:...:...:.||.:....|...||.|:...|.|.:.:||.::||:|:||:.|.|||
Zfish   345 AG--GAQITTKQVVTNVSELLGLDCFQLSEVLTQRSMILRGEEICSPLTVEQAIDSRDSVAMALY 407

  Fly   493 AGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKL 557
            :..|:|::.|||..::  |..:...|.||||||||:...|.|||..||||||.||.|||||:|.|
Zfish   408 SQCFSWIIMRINQKIK--GKDNFKSIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSL 470

  Fly   558 EQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSEL 622
            ||.||.||.:.|..:.|.||...:.|:.|| :|:..|:::||.||:.||.:.|||.|..|:.:..
Zfish   471 EQLEYNREGIHWEAIDWMDNAECLDLIEKK-LGMLALVNEESRFPKGTDFTLLEKLHGRHSTNPY 534

  Fly   623 YARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG 687
            |.:||:...:||:.||||:|.|.|.|.|:||||..|.|:|.:|..|||..:.:|.:|: :.|:..
Zfish   535 YVKPRLADHQFGIKHYAGEVLYDVRGILEKNRDTFRDDILNMLKDSRLDFIYDLFEQV-SSRNNE 598

  Fly   688 KTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQ 752
            :||..|:       ..:.|||:::|.|||..|:.::...:|:||||||||.:|...:.|...||.
Zfish   599 ETLKMGT-------ARKKPTVSSQFRDSLHSLMATLSVSNPFFVRCIKPNMDKTPNKFDPEVVLN 656

  Fly   753 QLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLL----PSPLARGTPYRELCRALLEAMPRTGV 813
            ||||.|||:|::||:.|:|||..|:.|..||:.:|    .:.:|.....::....||....:|..
Zfish   657 QLRYSGMLETVKIRRAGFPVRRTFKDFFTRYKIILKEKEKAAVASNGDDKKKSTDLLTIHDKTKK 721

  Fly   814 EGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWR 878
            |   :|.|.|:|||:|.|.:.||..|.|...:|.:.::.::...:.|:...:...:...:|..:|
Zfish   722 E---WQFGKTKVFLKETLEQKLEKQRDEVRSKAGLIIRAYLLRYIARKDFKKALESIVTIQKNYR 783

  Fly   879 GQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERS 943
            ....::|::|.|..||..|:..||:.||...::||.:.::|:|    .:|.::..:.|:...:|.
Zfish   784 THLYRRRFQRKRSAALVLQKHRRGQVARGVCRKLRDEKKKREE----EERKKKEEQEKKTEGDRE 844

  Fly   944 QLSYLDIPAELAFIYSKLQGWSP---PHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            :.:..:..||           ||   ....|.:.::|           :|..::.          
Zfish   845 KKNEEEDEAE-----------SPRTVEEDTRQMEEIL-----------RLEREIE---------- 877

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKAL 1070
                 .||.:||...:.|                             .|.:|::|          
Zfish   878 -----ILQKKREDSVSTL-----------------------------CESSKQEL---------- 898

  Fly  1071 SSRGLRD-EILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLR 1134
              |..|| |:|.|                               ..|.|:....|::        
Zfish   899 --RLRRDAEVLRQ-------------------------------KKAASRVATEFLE-------- 922

  Fly  1135 PLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS 1199
                   |...||                                 |..:|.:..| .|..|.|:
Zfish   923 -------LLDTGG---------------------------------PEVIPGDPKQ-AASRSATA 946

  Fly  1200 CEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPR-----SDLLR 1259
            .||.                  :|:|....:.|     :.|       |.||.|.     .::|.
Zfish   947 TEEE------------------VDEGFHAEEEC-----IPL-------PEFPPPAEGPVDQEILA 981

  Fly  1260 S----GAKFAR-TTLPDAVKRP--AVPPPAPP-------TSSGKEDVPRERRSSRELLSRSSALN 1310
            :    .|.||. |..|.|...|  |.|||:||       .:..:|..|.|.::.:|:        
Zfish   982 TLPPPPAAFAEGTVAPSAPNVPPGAPPPPSPPPPPPLPGETKKEEGKPEEAKTDKEV-------- 1038

  Fly  1311 ERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL-GLSESRLNDRYH 1374
                         .|...|:...|:..   |.|.:.:|     |::||:::: |..||..:    
Zfish  1039 -------------DGKKEGEDVDRTSR---LTAAESLP-----DTEEPIYSVPGDGESDYD---- 1078

  Fly  1375 SAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVR 1439
                            |.....|:.|.||:.|.|:           |.|..::.|:.        
Zfish  1079 ----------------QDDLEDGQSSIAATDGEHA-----------RKSTCTNASQE-------- 1108

  Fly  1440 RVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDD-LDDYIND 1503
                                                       ||.:.:::.:|.|| .|.|:  
Zfish  1109 -------------------------------------------SYNRSSDSYAESDDEHDGYV-- 1128

  Fly  1504 IFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKL 1568
                                              :.|||                  |:.|    
Zfish  1129 ----------------------------------DTDEE------------------VSNG---- 1137

  Fly  1569 TSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQL 1633
                  .|:|..|     ||                                             
Zfish  1138 ------KVNILNG-----NG--------------------------------------------- 1146

  Fly  1634 LAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPP 1698
                                                   ||...|.:.|||   .|::       
Zfish  1147 ---------------------------------------PPYFHSYLYMKA---GLMI------- 1162

  Fly  1699 PPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQR 1763
                                     |:.|         ||...:|       |.|..|:.:|...
Zfish  1163 -------------------------PWRR---------RWCVLKD-------ETFMWFRSKQESL 1186

  Fly  1764 KTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEI--------ESPTPPPMSGQLMRSSIR 1820
            |            :|.:.:.|.|....|....:...|.:        |:.:...:.|.:   .||
Zfish  1187 K------------SGWLYKKGGGLSTLSRRNWKMRWFVLRDSKLMYFENDSEEKLKGTI---DIR 1236

  Fly  1821 LETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQR 1885
                  .....|:|.:::...        ::||.   ::::::.|:.|...|.....||......
Zfish  1237 ------AAKEIVDNHEKENAL--------NIVTD---ERTYQVFAESPEDASGWFTMLSRVHNAS 1284

  Fly  1886 LEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQ 1950
            .||:         :....||..|.....|..:                     |::|        
Zfish  1285 PEQL---------LEMSHEQANPKNAVGTLDV---------------------GLID-------- 1311

  Fly  1951 IERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPD 2015
                                        ||.|...|.||.|..                      
Zfish  1312 ----------------------------SVCASDNPDRPNSFV---------------------- 1326

  Fly  2016 YRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAW-EQAERERSR 2079
             ..::::|:  |..:.:..:               .||                | ...::.:..
Zfish  1327 -IITANRVI--HCNSDLPEE---------------MHH----------------WISLLQKPKGD 1357

  Fly  2080 SRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPP 2144
            |:|   |.:::....|...|::..|..|..        :.::|.:.:                  
Zfish  1358 SKS---DGQEFLVRGWLHKEMKAGAKSSAL--------KLKKRWFVL------------------ 1393

  Fly  2145 RVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVP 2209
                                      ||.:..|....:|.:|.                      
Zfish  1394 --------------------------THNSLDYYKSSERNASK---------------------- 1410

  Fly  2210 APVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFA 2274
                                ||:        |..|.:                            
Zfish  1411 --------------------MGT--------LVLNSL---------------------------- 1419

  Fly  2275 QVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDM 2339
                       |..:.|:||.                                            
Zfish  1420 -----------CSVVQPEEKK-------------------------------------------- 1429

  Fly  2340 ARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAA 2404
                       |...|   |.::.:.|..||          |.:..:.::               
Zfish  1430 -----------FKETG---YWNIIVHGRKHS----------YRLYTKLLN--------------- 1455

  Fly  2405 LQLNLRNGKHLALHAAR-AAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQ 2468
                         .|.| .:|||.::..                          .||:|      
Zfish  1456 -------------EAMRWVSAIQGVIDN--------------------------KVPIE------ 1475

  Fly  2469 AHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQ 2533
                                                        ...||.:.|            
Zfish  1476 --------------------------------------------TPTQQLIRD------------ 1484

  Fly  2534 QQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQS----L 2594
                             :|:.|....|.:             |::.:..:|:..|....|    |
Zfish  1485 -----------------IKENSVNSEAVE-------------QMYRRNPILRYTQHPLHSPLLPL 1519

  Fly  2595 PHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQ 2659
            |:.::                               :|.||            ..:.|..|   |
Zfish  1520 PYGEV-------------------------------SDSLR------------KEKGYGSL---Q 1538

  Fly  2660 GHAIRLPLLRLPNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQ 2724
            ..|:     ::.|.|..:             :|..||    |..:..:|..||....||||||||
Zfish  1539 DEAV-----KIFNSLQEM-------------EIVSDP----VAIIQGILQTCHDLRPLRDEVYCQ 1581

  Fly  2725 LMKQTTANRSPCPDS-SQRA-WRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGT----- 2782
            |:|||  |..|.|:| :.|| |.||:.::..|..|.|:..||..||...    |....||     
Zfish  1582 LIKQT--NHVPQPNSPANRAHWHLLTCMSCTFLPSRAILRYLRFHLKRV----RERYPGTEIEKY 1640

  Fly  2783 AAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGA------------------- 2828
            |.....:|:||.   .|:.|||.||:.|:...:.....:|...||:                   
Zfish  1641 AHFIGESLKKTK---AREYVPSQEEIAALLIRQEMTTTVYCHGGGSCKISINSHTTAGEVVEKLI 1702

  Fly  2829 ---------------------ERVVNTRCSTVVADVIAELCALLGVESEAEQQE----FSLYCIV 2868
                                 .|.:.:|  .:||||:|:...|.|.|.|.|:..    |.|||.:
Zfish  1703 RGLAMENSRNMFSLFEHNKVESRAIESR--VIVADVLAKFERLTGSEEEEEEGPWRLYFKLYCFL 1765

  Fly  2869 QGDAFTMPLAADE--YILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAP- 2930
              |..:||....|  ::.:...|.|.||            ||     |||     |.....:|. 
Zfish  1766 --DVESMPKEGVEFAFMFEQAHESLISG------------HF-----PAP-----EETLQHLAAL 1806

  Fly  2931 --DYLEGLLLELP-----------------------GNGVPVPEMV------------------- 2951
              .|:.|.:...|                       |.|||...||                   
Zfish  1807 RLQYIHGDVARTPWSLSSVYPVGRLRTRIFQSTKAGGAGVPGAGMVGPGGHTLERRKTNFLDGTL 1871

  Fly  2952 RDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKA 3016
            |...:..:|..:..:..|:..|            .::|...|....:::. |.::..:...|...
Zfish  1872 RRSFKTGSLKKQRVEEEHMLEM------------FVKEEMSATLTSVLEK-WSRLQGMPQHQAML 1923

  Fly  3017 QFLNVLATWPLFGSSFFAVKRIWAEEG--PHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQH 3079
            .::.|:..||.:||:.|.|:   .:||  ||          ||.|.::...|........:.|:.
Zfish  1924 NYMTVIKEWPGYGSTLFDVE---CKEGGFPH----------DLWLGVSAENVSVYKRGEPKPLET 1975

  Fly  3080 WSFMEVI-------STRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITM 3133
            :.:..::       ||.|:               ::.:|.:..:|.|..||:::::.||.|
Zfish  1976 FQYEHIVFFGAPQPSTYKI---------------IVDEREMFFETSQVGEITKIMKAYINM 2021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 295/700 (42%)
MYSc_Myo15 169..828 CDD:276838 283/679 (42%)
MyTH4 1014..1171 CDD:295320 18/157 (11%)
MyTH4 2704..2810 CDD:279165 44/112 (39%)
B41 2823..3033 CDD:214604 55/300 (18%)
FERM_B-lobe 2920..3025 CDD:271216 20/149 (13%)
FERM_C_MyoXV 3029..3138 CDD:270022 24/114 (21%)
myo10l1XP_001924041.3 MYSc 63..745 CDD:214580 297/705 (42%)
MYSc_Myo10 77..733 CDD:276840 283/679 (42%)
MYO10_CC 862..911 CDD:293340 17/146 (12%)
PHA02664 <967..1139 CDD:177447 55/346 (16%)
PH-like 1153..>1184 CDD:302622 12/81 (15%)
PH2_MyoX 1187..1288 CDD:270108 20/132 (15%)
PH 1187..1280 CDD:278594 19/124 (15%)
PH3_MyoX-like 1353..1478 CDD:270109 36/440 (8%)
PH 1368..1468 CDD:278594 30/336 (9%)
MyTH4 1561..1665 CDD:279165 44/112 (39%)
B41 1676..1940 CDD:214604 56/302 (19%)
FERM_M 1772..1940 CDD:278785 34/202 (17%)
FERM_C_MyoX 1936..2024 CDD:270023 24/114 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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