Protein Alignment Myo10A and myo1cb

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_073779253.1
• Gene: myo1cb / 566459
• ZFINID: ZDB-GENE-090429-3
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1034
• Identity: 326/1034 - (31%)
• Similarity: 512/1034 - (49%)
• Gaps: 188/1034 - (18%)

  Fly   143 EGSLRARQDLGSSGVEDMTLLDD-LHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYG 206
            |.:|.||..:   ||:|..||:: ..|.:.:.|||.|:.:.||||:.||:|::|||||.. :.|.
Zfish    44 ESALTARDRV---GVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDL-EIYT 104

  Fly   207 LEVAKQYAGRPLGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVP 268
            .:..::|.|.....:.||::|:...|:.::.:   .|.::||||||:||||::|.|:||.|...|
Zfish   105 KQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCP 169

  Fly   269 GGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSR 332
            .......| .:::|::.|:|||||||:|.|||||||||||:::.|. .||.||..|..|||||||
Zfish   170 ASDHVQTV-KDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSR 233

  Fly   333 IVTQAPGERNYHVFYELLGGLSETERSKYGL-LEADKYFYLNQGATDC-----ASGRVDWESLQG 391
            :|.|:.||||:|:||:|:.|..:....:.|| ..|.:|.||.:|  :|     .:.|.||::::.
Zfish   234 VVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKG--NCPKVSSINDRNDWKTVRK 296

  Fly   392 AMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE---GVEVGSDAEIKWAAHLLHISAD 453
            |:.|:|.::.|.|.::.::|:|||||||       ::|.|   ...:.:|.:||:.|.||.:...
Zfish   297 ALSVIGFTDDEVEELLNIIASVLHLGNV-------QYGGEDSGSAYITTDTQIKYLARLLGVDGT 354

  Fly   454 GLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV----QKGGTHD 514
            .|..|||.:...|:.|.|.:||..:||..||||.:||:|...|:|||::||..:    :...:.:
Zfish   355 VLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKN 419

  Fly   515 AHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLP 579
            |..|.:|||:|||....|||||.||||.||.||..|.:...|.||.||..|.:.|.|:.:.:|..
Zfish   420 ASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKI 484

  Fly   580 VIHLLAKKPVGICHLLDDESNFP-RATDLSFLEK--------CHY-NHALSELYARPRIGAQEFG 634
            :..|:.:|..||..:||:|...| .|:|::||||        .|: .|.|::...|..:|.:||.
Zfish   485 ICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFR 549

  Fly   635 VTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFV 699
            :.||||:|.|.|.||||||.|.|..::.:::..|.                 .|.|.:..:...:
Zfish   550 LIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSE-----------------NKILNQCFDREEL 597

  Fly   700 TMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQ 764
            :.|.|..|.|.:|.:||.:|::.:....|.:|||||||..|.|.|.|...:..|::|||:::.::
Zfish   598 SDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLR 662

  Fly   765 IRQRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFL 827
            :|:.|:..|.|::.|::||:.|.|.  |...|   |:: ..:...:...|.:..:|:||.|::|:
Zfish   663 VRRAGFAYRRRYETFLQRYKSLCPDTWPNWDG---RQV-DGVSTLVKHLGYKPEEYKLGRTKIFI 723

  Fly   828 R-----EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYE 887
            |     .|...|||                           .|:.:.||:||:.|:|...:.:|:
Zfish   724 RFPKTLFATEDALE---------------------------VRKHSLATQLQSSWKGYSQKTKYQ 761

  Fly   888 RLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREA---REAKQAVLERSQLSYLD 949
            ::|..|:..|..|||..|||..       :||:||.:..:|..:.   |...:.......|.|:.
Zfish   762 KMRHSAVWIQAWWRGILARRAA-------KRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVR 819

  Fly   950 IPAELAFIYSKL-------------QGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK 1001
                    ||.|             :.|                |.||.:.|:..:.|.:.....
Zfish   820 --------YSFLMNLHRCQPKTVLDKSW----------------PTPPPALVEASQHLRKLCMQN 860

  Fly  1002 FSSVYCNGLRLQPRRE------------------PITAPLL---TRAASRD-----------QDF 1034
            ....||..:..:.:.:                  |.:.|.|   ||....|           :..
Zfish   861 MVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKM 925

  Fly  1035 QDALAVFK------------LILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            :.|:.|.|            |:|...:...:|..|.|...||...|.:|...|.|.:.|
Zfish   926 KYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFV 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	254/687 (37%)
		PTZ00121	<828..>943	CDD:173412	28/122 (23%)
		MyTH4	1014..1171	CDD:470587	21/112 (19%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo1cb	XP_073779253.1	None