DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myo7bb

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_021322875.1 Gene:myo7bb / 566034 ZFINID:ZDB-GENE-070912-482 Length:2189 Species:Danio rerio


Alignment Length:3183 Identity:679/3183 - (21%)
Similarity:1091/3183 - (34%) Gaps:1263/3183 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 SLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEV 209
            :|:........||:||..|.||.||.||.||.||:.:|:|||:.||:|:|:|||:|.| .|..:.
Zfish    51 ALKPMHPTSVEGVDDMICLGDLSEAGLLRNLFLRHKQGIIYTYIGSVLVAMNPYEMLP-IYTADQ 114

  Fly   210 AKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGG 271
            .:||.||.||.||||:|||..:.:..:   ...|..:||||||:||||||||::|:||||    .
Zfish   115 VQQYHGRKLGELPPHIFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAV----S 175

  Fly   272 SASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVT 335
            ...:.|.:||::|.|:|||||||:|.|||||||||||:|::| |:|.|.||.:.||||||||:..
Zfish   176 GQHSWIEQQIIQANPILEAFGNAKTIRNDNSSRFGKYVEIFFNKAGVIEGAHMEQYLLEKSRVCH 240

  Fly   336 QAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDC--ASGRVD---WESLQGAMQV 395
            ||..|||||:||.:|.|:....:....|.:|.::.||.:|  ||  ..||.|   :..::.|::|
Zfish   241 QALQERNYHIFYCMLAGMQSDHKKTLSLGDASEFNYLTEG--DCLTCDGRDDADEFARIRSALKV 303

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALT 460
            |..::.:...|.::|||:||:||:.| :..:.:..:..:|.|.:.....|.||.:....|.::||
Zfish   304 LTFTDRDCWEIFKLLAAILHMGNIDF-QSTIMNNMDSCDVLSSSHFSVIAKLLEVDDAALDKSLT 367

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT----HDAHRISIL 521
            .|:.....|.:..||..:||.|.|||||||||..||.|:.::|||.:.|..|    :....|.:|
Zfish   368 HRSFMTNREMVTKPLSSEQATDIRDAFAKALYGRLFVWMFTKINSAIHKPQTDEPSYTRQSIGLL 432

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||||||:..:|||||||||:|||:||.:|.:|||||||.||.:|.:.|..:|::||...:.|||.
Zfish   433 DIFGFENFPQNSFEQLCINFANEHLQQFFVRHVFKLEQDEYTKEGISWKRIAFNDNQKTLDLLAL 497

  Fly   587 KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFL 650
            ||:.|..|:|:||:||:.||.:.|.|....|..::||...|...: .|||.|:||.|:|..:|||
Zfish   498 KPLNILALIDEESHFPKGTDATMLNKLSQEHKGNKLYISSRGDHRIHFGVQHFAGLVYYDCEGFL 562

  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQ---LRAQRDAGK-----TLPKGSNGRFVTMKPRTPT 707
            :||||.:..|:|||:..|...|:.::.::   :.:.:::.|     ..||.|..:....:.:..|
Zfish   563 EKNRDTVSMDILELIRKSSNKLLKQIFEKEINVNSVKNSNKMNKAVMTPKNSLRQVNESRRQIST 627

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEK------------------HALRM--------- 745
            ::.:|..||..|::::..|.|:|:||.|||.:|                  .|.:|         
Zfish   628 LSGQFRQSLDSLMKALSLCQPFFIRCFKPNDKKLPMVSIHFNITYILSSCEDAFKMTFSLYFPHQ 692

  Fly   746 --DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS--------PLARGTPYREL 800
              :....:|||||.|||:||:||:.|||:|..|:.|:.|||.||.|        |.|:..  ..:
Zfish   693 VFNRELCMQQLRYSGMLETIRIRKLGYPIRHTFKDFLHRYRALLKSIDCDPNTEPAAKCC--AAI 755

  Fly   801 CRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLAR 865
            ||.|::       :..|:::|.|:||||......||..|.:.|.|.|:.:||.:.....|:....
Zfish   756 CRTLIK-------DEEDWKIGKTKVFLRGHHDTYLELERAQELYRKALIIQRVMLAHKDRKNFIN 813

  Fly   866 RQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAR 930
            ::.||..||..|||.:.::.:..:::|   ..||    ||:.|.::|..::.||:.|        
Zfish   814 KRKAALVLQKNWRGYKEKRDFCTVKQG---FARL----QAKVRSRKLHEEYMRRRAA-------- 863

  Fly   931 EAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLG 995
                   |::.::|                                                   
Zfish   864 -------AIVLQTQ--------------------------------------------------- 870

  Fly   996 QFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKL 1060
                                    |..||.|                        |.|:..||.:
Zfish   871 ------------------------TRGLLAR------------------------KELKSKKEAV 887

  Fly  1061 LADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125
                              ||:|                                           
Zfish   888 ------------------ILLQ------------------------------------------- 891

  Fly  1126 DDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQ 1190
                                                         |.|||               
Zfish   892 ---------------------------------------------AQTRG--------------- 896

  Fly  1191 TVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRS 1255
                                                             |:|.|.|         
Zfish   897 -------------------------------------------------LLARKSL--------- 903

  Fly  1256 DLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSP 1320
                                                   :|..|.|.|:                
Zfish   904 ---------------------------------------KRMKSEEFLT---------------- 913

  Fly  1321 GPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKD 1385
                        ::.|...:|.|.::                   :.||.:.....|..|     
Zfish   914 ------------AQEKQAQELAALEL-------------------QQRLEELLRKNEETA----- 942

  Fly  1386 TGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDV 1450
                                                                      .||.::.
Zfish   943 ----------------------------------------------------------KSQNNED 949

  Fly  1451 DQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLE 1515
            ::.::::|:              .|..:|.|    ||..|....::        |:..|     .
Zfish   950 EEMVENIFN--------------FLPTAIAG----QEGPAPEGFEE--------FEAEP-----A 983

  Fly  1516 KLTSKDQLAAIIKGGGVASKPEE------RDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHL 1574
            ||...:.:.:.:....|.|.||.      ::||.|.|| |::....|..:             |.
Zfish   984 KLEEVELIESPVVETKVMSIPESSEDHQVKEEEEEEED-DEFSFSKFASL-------------HF 1034

  Fly  1575 AVSIRGGGSTDS----NGADPLLHQ---------------LMQLPGETESGPALYQQQVQRAFLQ 1620
            .     |.||.|    ....|||:.               :::..|:.   |...|::|      
Zfish  1035 Q-----GASTHSYIQQRLRQPLLYHEDEGDTLACLTVWWIILRFMGDL---PEPKQERV------ 1085

  Fly  1621 SAMAQNLQIQQQLLAQNQA-------------LQTLLSQQAAAAAANNSTSPPPAPPILSSLSIS 1672
            ||||..:   |:.|.|.||             |:..:.||.......:|..|...|         
Zfish  1086 SAMADPI---QRNLGQRQARRLSNLVGLDQKFLRKKMKQQKGGGKRKHSAIPEEEP--------- 1138

  Fly  1673 PPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWR 1737
            ...|:|  :|:|.:...||:....|....|..|:          |..|.:..|...:        
Zfish  1139 EEEPKS--QMEAVQEEQVVLFGEGPTFDRPMTPL----------EKLHIIVGYAIVR-------- 1183

  Fly  1738 WPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEI 1802
             |..:||...|..:                     |:|.|                         
Zfish  1184 -PDIRDEIYCQICK---------------------QLTGN------------------------- 1201

  Fly  1803 ESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVV------TTKLAK--K 1859
                                              ::|::.:.|..:.|:.      |.:|.|  :
Zfish  1202 ----------------------------------KNRKSVNRGWILLSICLGIFSPTERLTKYLQ 1232

  Fly  1860 SFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLG 1924
            ||.         ..|..:.|:...:||         |.|::.......|..:|      ||    
Zfish  1233 SFI---------RCGPSEYSAYCAERL---------RRTLANGERNEPPCWVE------LQ---- 1269

  Fly  1925 GLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRP 1989
                  |..|..|.||.         :..|:|:             .:.|               
Zfish  1270 ------SVENKNPIGVA---------VGLMDGR-------------NISL--------------- 1291

  Fly  1990 PSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHL 2054
                            |..|.....:..|:.||          ....:|:||......|.     
Zfish  1292 ----------------TVDSASTSAEVCTAISQ----------NTNLQDSFGFSLYAAMY----- 1325

  Fly  2055 HLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERE 2119
                                                 |.:|        :.||||:         
Zfish  1326 -------------------------------------EKMW--------SLGSGSQ--------- 1336

  Fly  2120 RERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRK 2184
                                     .::.|                        ....|.|.||:
Zfish  1337 -------------------------HILDA------------------------VSMCEQEEKRQ 1352

  Fly  2185 SSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWK 2249
            .      |||                                                 ...||:
Zfish  1353 G------REE-------------------------------------------------QHAPWR 1362

  Fly  2250 LRVRKEVFQP-HEPIGPPVALDLLFAQVL-----GDVFG-------------------------- 2282
            |..|||:|.| |:.....::.:|::.|::     |:...                          
Zfish  1363 LYFRKEIFTPWHDCSSDQISTELIYRQIIHGLKNGEYLSDKEDDYVQLAAKHYYVQHGSESSLEI 1427

  Fly  2283 ----VTPCLRITPQEKSS------ALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLV 2337
                |..|:.:|..|..|      .:|..|..|..::|             |....:  ||...|
Zfish  1428 AQKIVRDCMNMTIIENKSLVKLVQLVNSAHTQGPYINT-------------NTPVYK--VKSETV 1477

  Fly  2338 DMARD-WPLYFARLFAVQ--GAPLYP-DVSIMGVSHSGLYLA-RRDADYLIV-------VQAISF 2390
            :.|:. ||::|::|:..|  ..|..| |..::.|:..|::.. ..:.::|.:       ::.:|.
Zfish  1478 EYAQQKWPIHFSKLYEAQVISGPSVPQDQFVVVVNWKGVFFQDETEGEFLQLSYPEVSRIEIVSE 1542

  Fly  2391 GEIQSAVTLPRPAAL-QLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAA 2454
            ......|.|..|..: :|.:..||.|.          .:|..|:...::....|..:...:|...
Zfish  1543 DRSGGLVCLTTPKGMYELKIVKGKELV----------ELVNMFISGLKERSMYAVAIQDLSRQED 1597

  Fly  2455 QTLNVPLERLESRQAHA----QRNEHGVDGG--SRQNEQLQQS---ELHHHLQQQQQQQQQQQHH 2510
            .||      |..|:...    :..|:.::.|  ..:||:..|:   .|                 
Zfish  1598 PTL------LSYRRGDVLYIIKDGEYSLEEGWIKARNERTSQTGAVSL----------------- 1639

  Fly  2511 QQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNG 2575
                      ||::...|.|...::....|.               |..||:.:.  .|      
Zfish  1640 ----------DAIQILPMLTRPTEETLNLLN---------------LSPARRKSV--MP------ 1671

  Fly  2576 QVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRH 2640
                   :|.|:::.|.....|                          ..::.|..|..||....
Zfish  1672 -------VLPQKEELSTERVAH--------------------------MTLKEFSFDYFRDPVNE 1703

  Fly  2641 HERHQSAANRSYAELVKWQGHAIRLPLLRL---PNDLAPLALECFDCILRYCGDIPLDPDLTEVK 2702
            ..|.:....:.:|.    ....::.||:|.   .::|..||.:.|..||:|.||.|:....|.:.
Zfish  1704 GRRGKGGKEKLWAN----SKEPLKQPLIRNLQGNSELCHLASDSFTAILKYMGDYPVKHVRTPID 1764

  Fly  2703 CVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEH 2767
            ....:......::.||||:|||:|||.|.||:..  |.:|.|:||.:....|..|..|..:....
Zfish  1765 LTNQIFGPATAHVELRDEIYCQIMKQMTNNRNGL--SMERGWQLLWLCCGLFPPSQLLLRHAQRF 1827

  Fly  2768 LTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIY---RLPGGAE 2829
            |.|      |.....|:.||..::......|||..|...||.|:   ::...||:   ..|....
Zfish  1828 LES------RPREPLASACLQRMQAMLSIEGRKLPPHQVEVDAI---QNNSTQIFHKVHFPNDTS 1883

  Fly  2830 RVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILD---VTTELL 2891
            .:.....:|.:.|:...:...|.:.|   .:.:||:  |:.......:.::||..|   ..|::.
Zfish  1884 EIFEVTTTTRIKDLCRNIAKDLRLSS---PEGYSLF--VKTSTKVESMNSEEYFFDNLRQLTDVT 1943

  Fly  2892 KSGQ----------PFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVP 2946
            |.|:          |:.::|.|.:|...:..:.....|...  |.|..|.||.|.      :.| 
Zfish  1944 KKGKKVREATPTIVPYLVLFMRKLWFNVIPGKDITADLMFH--FPQELPKYLRGY------HSV- 1999

  Fly  2947 VPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPA---------QWVGLVQSA 3002
               ...||..:..||.|    :.|.|.|....::|:.   ::|:.||         .|...:.::
Zfish  2000 ---SKEDMIALGGLLFR----TRVDADKSQFVMIPRM---LKELVPADQQKIMTAEDWKKHIINS 2054

  Fly  3003 WPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVL 3067
            :.:.|.:|..:.|.|||..::.||.||.:||.||:...:..|.|          ::::::::|:.
Zfish  2055 YNKQAGMSVDEAKLQFLKTVSPWPTFGCAFFEVKQTSEKNYPSV----------IMISISKQGIS 2109

  Fly  3068 FLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQY 3130
            .::..|.|.|....|.::.|.     ..|:.:..|.:|||:|...:..:|.|.::||.|:..|
Zfish  2110 LINSKTKEVLAAHLFSKITSW-----SSGSTYFHMTIGNLVQGNTLLCETSQGYKISDLLSSY 2167

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 300/738 (41%)
MYSc_Myo15 169..828 CDD:276838 290/717 (40%)
MyTH4 1014..1171 CDD:295320 11/156 (7%)
MyTH4 2704..2810 CDD:279165 33/105 (31%)
B41 2823..3033 CDD:214604 49/231 (21%)
FERM_B-lobe 2920..3025 CDD:271216 26/113 (23%)
FERM_C_MyoXV 3029..3138 CDD:270022 25/102 (25%)
myo7bbXP_021322875.1 MYSc_Myo7 75..776 CDD:276832 290/717 (40%)
ERM 855..>997 CDD:330563 48/614 (8%)
MyTH4 1176..1270 CDD:307090 26/216 (12%)
B41 1279..1492 CDD:214604 56/453 (12%)
PH-like 1486..1582 CDD:327399 19/105 (18%)
SH3 1583..1635 CDD:327375 11/57 (19%)
MyTH4 1718..1866 CDD:214535 48/158 (30%)
B41 1873..2085 CDD:214604 49/235 (21%)
FERM_C2_MyoVII 2081..2176 CDD:270020 25/102 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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