Protein Alignment Myo10A and myo1f

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001243600.1
• Gene: myo1f / 565345
• ZFINID: ZDB-GENE-081104-506
• Length: 1095
• Species: Danio rerio
• Alignment Length: 1264
• Identity: 338/1264 - (26%)
• Similarity: 548/1264 - (43%)
• Gaps: 315/1264 - (24%)

  Fly   150 QDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYA 214
            |::..|||:||.||..:.|.:::.||:.|:....|:|:.|.:||:|||:|..|.....|: :.|.
Zfish    10 QNVKQSGVDDMVLLSKITEDAIVENLKKRFLDDYIFTYIGPVLISVNPFKQMPYFTDREI-ELYQ 73

  Fly   215 GRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV 276
            |......|||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.||||....
Zfish    74 GAAQYENPPHIYALTDNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMGYISK-VSGGGSKVQH 137

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:.||::.|||||||||:|.||:||||||||.|:.| :.|...|.||:.:||||||:|:|...|
Zfish   138 VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENE 202

  Fly   341 RNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEGE 402
            ||:|:||:|:.|.:..::...|::..|.|:||||..|   |..:...|::....||||:|:.|..
Zfish   203 RNFHIFYQLIDGCTPQQKEGLGIMTPDYYYYLNQSGTYKVDGTNDSKDFQETMEAMQVIGIPEMH 267

  Fly   403 REGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRALTS 461
            :...::::|.:||||::.|           :|||:..:::      :.|:||.|..:.|...|||
Zfish   268 QTLALQIVAGILHLGSINF-----------IEVGNYGQVESTDLLAFPAYLLGIDQNRLQEKLTS 321

  Fly   462 RTTEA----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILD 522
            |..::    :.|.::..|.::||...|||.|||||..||::||..||..:||  ..:...:.:||
Zfish   322 RIMDSKWAGKTESINVTLNLEQARHTRDALAKALYTRLFDYLVEEINKAMQK--PIEELSVGVLD 384

  Fly   523 IFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKK 587
            |:|||....|.|||.|||:.||.||..|.:...|.||.||.:|.::|||:.:.:|..|..|:..|
Zfish   385 IYGFEIFQRNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIKWTPIEYFNNKIVCDLIENK 449

  Fly   588 --PVGICHLLDDESNFPRAT----DLSFLEKC--------HYNHALSELYARPRIGAQEFGVTHY 638
              |.||..:|||......||    |::.|:|.        |:|...|           .|.:.||
Zfish   450 LSPPGIMSVLDDVCATMHATKDGADMTLLQKLQNAVGTHDHFNSWNS-----------GFIIHHY 503

  Fly   639 AGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKP 703
            ||:|.|.::||.::|||.|..|::||:.||:...:..|             .|:..|   ...|.
Zfish   504 AGKVSYDINGFCERNRDVLFPDLIELMQSSQYDFIQSL-------------FPENLN---TDKKG 552

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
            |..|..::......:|:.::.:|.|.::||||||:.|.....:......|:.|||:.:.|::|:.
Zfish   553 RPTTAGSKIKRQANELVSTLMKCTPHYIRCIKPNETKRPKDWEESRARHQVEYLGLRENIRVRRA 617

  Fly   769 GYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--E 829
            |:..|..|..|:.||..|...  |..||...    :.:|..:....:|...||:|.:::|::  |
Zfish   618 GFAYRRIFPKFLHRYAILTAETWPCWRGAEQ----QGVLHLLRTVNMETDQYQMGRSKIFIKNPE 678

  Fly   830 ALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGAL 894
            :|. .||..|..:....|.::|:                       .||...|:::||::|:.|
Zfish   679 SLF-LLEEMRERKFDTFARTIQK-----------------------AWRKYIARRKYEQMREEA- 718

  Fly   895 TAQRLWRGRQARRRV--QQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFI 957
             :..|:..::.||..  :....|:...:          :..|.:|.:.:|.::.:.|
Zfish   719 -SDILYNSKERRRNSINRNFVGDYLGME----------DRPELRQFMAKRERVDFAD-------- 764

  Fly   958 YSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQL--------PEDLGQFSFGKFSSVYCNGLRLQP 1014
                   |....||....:...:...|.|...:        ||. ||..            .:..
Zfish   765 -------SVNKFDRRFKSIKRDLILSPKSIYLIGREKIKKGPEK-GQIK------------EVLK 809

  Fly  1015 RREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK----ALSSRGL 1075
            ||..|:.......::|..||                             :|:|:    :|.....
Zfish   810 RRLDISGIRSVSLSTRQDDF-----------------------------FILHETEYDSLLESMF 845

  Fly  1076 RDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQ 1140
            :.|.|..||.:..       |.||                  ||..:.|.|          .|:.
Zfish   846 KTEFLTLLCKRYE-------EQTR------------------SKLTLSFSD----------RLQF 875

  Fly  1141 LLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAA 1205
            .::::|.       |.|:.|..|        :.||           :|.:.|
Zfish   876 NVKKEGW-------GGGSTRMVV--------FQRG-----------QADEAV------------- 901

  Fly  1206 LAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSG------AKF 1264
                   :.:.|.||.:..|..|..:..        ..::..|.....||.....|      |:|
Zfish   902 -------IKAGGKTLTVSVGDGLPKTSK--------PTRKGMPQSHGGRSQPQHRGGHQNGAAQF 951

  Fly  1265 AR----------TTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALN--------- 1310
            .|          .|....|:..  |||:.|...|.:   :.:|.||.:.::|:.|:
Zfish   952 HRGGGQQQQQKEVTYSMPVRHN--PPPSNPLKLGSQ---KNQRGSRPVQNQSTNLDFLNVPDQGM 1011

  Fly  1311 -----ERYFEREPSPGPGQGSSTGQAKSR 1334
                 ::...:.|.|.|   ||..:.::|
Zfish  1012 SGMQRKKSISQRPPPAP---SSRPKPQAR 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	238/691 (34%)
		PTZ00121	<828..>943	CDD:173412	20/118 (17%)
		MyTH4	1014..1171	CDD:470587	26/160 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	7/66 (11%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo1f	NP_001243600.1	MYSc_Myo1	29..675	CDD:276829	238/691 (34%)
		Myosin_TH1	715..913	CDD:461801	52/347 (15%)
		SH3_MyoIe_If_like	1042..1094	CDD:212761